Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Tommer Ravid"'
Autor:
Bayan Mashahreh, Shir Armony, Kristoffer Enøe Johansson, Alon Chappleboim, Nir Friedman, Richard G. Gardner, Rasmus Hartmann-Petersen, Kresten Lindorff-Larsen, Tommer Ravid
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
How misfolded proteins are selected by the ubiquitin-conjugating system for elimination is largely unknown. Here, the authors identify conserved features of proteome-derived degradation signals, including amino acid and structural preferences, that t
Externí odkaz:
https://doaj.org/article/cf7027894a32433c80084976497c6a94
Publikováno v:
Biomolecules, Vol 13, Iss 6, p 987 (2023)
Quality control-associated proteolysis (QCAP) is a fundamental mechanism that maintains cellular homeostasis by eliminating improperly folded proteins. In QCAP, the exposure of normally hidden cis-acting protein sequences, termed degrons, triggers mi
Externí odkaz:
https://doaj.org/article/e2bb61300ba34a54880a27e5f113f5ee
Autor:
Lene Clausen, Amelie Stein, Martin Grønbæk-Thygesen, Lasse Nygaard, Cecilie L Søltoft, Sofie V Nielsen, Michael Lisby, Tommer Ravid, Kresten Lindorff-Larsen, Rasmus Hartmann-Petersen
Publikováno v:
PLoS Genetics, Vol 16, Iss 11, p e1009187 (2020)
Germline mutations in the folliculin (FLCN) tumor suppressor gene are linked to Birt-Hogg-Dubé (BHD) syndrome, a dominantly inherited genetic disease characterized by predisposition to fibrofolliculomas, lung cysts, and renal cancer. Most BHD-linked
Externí odkaz:
https://doaj.org/article/aa4119d02042406da6db2f208f892697
Autor:
Yotam David, Inês Gomes Castro, Eden Yifrach, Chen Bibi, Enas Katawi, Dekel Yahav Har-Shai, Sagie Brodsky, Naama Barkai, Tommer Ravid, Miriam Eisenstein, Shmuel Pietrokovski, Maya Schuldiner, Einat Zalckvar
Publikováno v:
Cells, Vol 11, Iss 9, p 1426 (2022)
Peroxisomes host essential metabolic enzymes and are crucial for human health and survival. Although peroxisomes were first described over 60 years ago, their entire proteome has not yet been identified. As a basis for understanding the variety of pe
Externí odkaz:
https://doaj.org/article/4b44ee2265f14b688659cb26792b19ed
Autor:
Lorna Moll, Noa Roitenberg, Michal Bejerano-Sagie, Hana Boocholez, Filipa Carvalhal Marques, Yuli Volovik, Tayir Elami, Atif Ahmed Siddiqui, Danielle Grushko, Adi Biram, Bar Lampert, Hana Achache, Tommer Ravid, Yonatan B Tzur, Ehud Cohen
Publikováno v:
eLife, Vol 7 (2018)
Although aging-regulating pathways were discovered a few decades ago, it is not entirely clear how their activities are orchestrated, to govern lifespan and proteostasis at the organismal level. Here, we utilized the nematode Caenorhabditis elegans t
Externí odkaz:
https://doaj.org/article/b31f6b8500b049b2928dc3c11f46757c
Publikováno v:
Biomolecules, Vol 10, Iss 8, p 1168 (2020)
Intracellular protein inclusions are diverse cellular entities with distinct biological properties. They vary in their protein content, sequestration sites, physiological function, conditions for their generation, and turnover rates. Major distinctio
Externí odkaz:
https://doaj.org/article/c6af64746fe341c7b1151b6559598ba7
Autor:
Meytal Radzinski, Rosi Fassler, Ohad Yogev, William Breuer, Nadav Shai, Jenia Gutin, Sidra Ilyas, Yifat Geffen, Sabina Tsytkin-Kirschenzweig, Yaakov Nahmias, Tommer Ravid, Nir Friedman, Maya Schuldiner, Dana Reichmann
Publikováno v:
eLife, Vol 7 (2018)
Cellular redox status affects diverse cellular functions, including proliferation, protein homeostasis, and aging. Thus, individual differences in redox status can give rise to distinct sub-populations even among cells with identical genetic backgrou
Externí odkaz:
https://doaj.org/article/d0840b033b04419592b96828f318e0ba
Autor:
Ayala Shiber, Tommer Ravid
Publikováno v:
Biomolecules, Vol 4, Iss 3, Pp 704-724 (2014)
Molecular chaperones were originally discovered as heat shock-induced proteins that facilitate proper folding of proteins with non-native conformations. While the function of chaperones in protein folding has been well documented over the last four d
Externí odkaz:
https://doaj.org/article/5a0bebdbcbea4e2aa18ac85577b31c3c
Publikováno v:
Biomolecules, Vol 9, Iss 6, p 230 (2019)
Since the discovery of ubiquitin conjugation as a cellular mechanism that triggers proteasomal degradation, the mode of substrate recognition by the ubiquitin-ligation system has been the holy grail of research in the field. This entails the discover
Externí odkaz:
https://doaj.org/article/95082fbaf096435ebef108f61d35f733
Autor:
Simone Filosto, Elaine M Khan, Emiliana Tognon, Cathleen Becker, Majid Ashfaq, Tommer Ravid, Tzipora Goldkorn
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23240 (2011)
Crystallographic studies have offered understanding of how receptor tyrosine kinases from the ErbB family are regulated by their growth factor ligands. A conformational change of the EGFR (ErbB1) was shown to occur upon ligand binding, where a solely
Externí odkaz:
https://doaj.org/article/ad7c71ddeaeb48ff8095e88b9c2d16a6