Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Tommaso Ristori"'
Publikováno v:
npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-16 (2024)
Abstract Endothelial cells are key players in the cardiovascular system. Among other things, they are responsible for sprouting angiogenesis, the process of new blood vessel formation essential for both health and disease. Endothelial cells are stron
Externí odkaz:
https://doaj.org/article/cb191cbcb77248da8113260fe334563f
Autor:
Cansu Karakaya, Mark C. van Turnhout, Valery L. Visser, Tommaso Ristori, Carlijn V. C. Bouten, Cecilia M. Sahlgren, Sandra Loerakker
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Mechanical stimuli experienced by vascular smooth muscle cells (VSMCs) and mechanosensitive Notch signaling are important regulators of vascular growth and remodeling. However, the interplay between mechanical cues and Notch signaling, and its contri
Externí odkaz:
https://doaj.org/article/32e24e29affd4d51a7aefb8f4b344249
Autor:
Laura A. Tiemeijer, Tommaso Ristori, Oscar M.J. A. Stassen, Jaakko J. Ahlberg, Jonne J.J. de Bijl, Christopher S. Chen, Katie Bentley, Carlijn V.C. Bouten, Cecilia M. Sahlgren
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104306- (2022)
Summary: Spatial regulation of angiogenesis is important for the generation of functional engineered vasculature in regenerative medicine. The Notch ligands Jag1 and Dll4 show distinct expression patterns in endothelial cells and, respectively, promo
Externí odkaz:
https://doaj.org/article/12b2080bc44b4032aee0d44300b97ab0
Autor:
Robert Hinch, William J M Probert, Anel Nurtay, Michelle Kendall, Chris Wymant, Matthew Hall, Katrina Lythgoe, Ana Bulas Cruz, Lele Zhao, Andrea Stewart, Luca Ferretti, Daniel Montero, James Warren, Nicole Mather, Matthew Abueg, Neo Wu, Olivier Legat, Katie Bentley, Thomas Mead, Kelvin Van-Vuuren, Dylan Feldner-Busztin, Tommaso Ristori, Anthony Finkelstein, David G Bonsall, Lucie Abeler-Dörner, Christophe Fraser
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 7, p e1009146 (2021)
SARS-CoV-2 has spread across the world, causing high mortality and unprecedented restrictions on social and economic activity. Policymakers are assessing how best to navigate through the ongoing epidemic, with computational models being used to predi
Externí odkaz:
https://doaj.org/article/40c60c6d49f340eba2196f65ed314e7d
Autor:
Antonetta B.C. Buskermolen, Tommaso Ristori, Dylan Mostert, Mark C. van Turnhout, Siamak S. Shishvan, Sandra Loerakker, Nicholas A. Kurniawan, Vikram S. Deshpande, Carlijn V.C. Bouten
Publikováno v:
Cell Reports Physical Science, Vol 1, Iss 5, Pp 100055- (2020)
Summary: In the presence of anisotropic biochemical or topographical patterns, cells tend to align in the direction of these cues—a widely reported phenomenon known as “contact guidance.” To investigate the origins of contact guidance, here, we
Externí odkaz:
https://doaj.org/article/1e6ae96f97354249a769a08c18a428d1
Autor:
Jordy G. M. van Asten, Marcos Latorre, Cansu Karakaya, Frank P. T. Baaijens, Cecilia M. Sahlgren, Tommaso Ristori, Jay D. Humphrey, Sandra Loerakker
Publikováno v:
Biomechanics and Modeling in Mechanobiology.
Blood vessels grow and remodel in response to mechanical stimuli. Many computational models capture this process phenomenologically, by assuming stress homeostasis, but this approach cannot unravel the underlying cellular mechanisms. Mechano-sensitiv
Autor:
Tommaso Ristori, S Sandra Loerakker
Publikováno v:
Current Opinion in Biomedical Engineering
Understanding cardiovascular growth and remodeling (G&R) is fundamental for designing robust cardiovascular tissue engineering strategies, which enable synthetic or biological scaffolds to transform into healthy living tissues after implantation. Com
Publikováno v:
Tissue Engineering Part C: Methods
Autor:
Robert Gaul, Tommaso Ristori, S Sandra Loerakker, Carlijn V. C. Bouten, Caitríona Lally, D.R. Nolan
Publikováno v:
Journal of the Mechanical Behavior of Biomedical Materials
Journal of the Mechanical Behavior of Biomedical Materials, 109:103771. Elsevier
Journal of the Mechanical Behavior of Biomedical Materials, 109:103771. Elsevier
Collagen fibre degradation is a strain-dependent process, whereby the magnitude of experienced strain dictates the rate of enzymatic cleavage. Studies have identified conflicting findings as to whether strain inhibits or enhances collagen degradation
Publikováno v:
Journal of Cell Science
J Cell Sci
J Cell Sci
Tissue development and homeostasis are controlled by mechanical cues. Perturbation of the mechanical equilibrium triggers restoration of mechanostasis through changes in cell behavior, while defects in these restorative mechanisms lead to mechanopath