Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Tommaso Cupido"'
Publikováno v:
ARKIVOC, Vol 2005, Iss 6, Pp 191-199 (2005)
Externí odkaz:
https://doaj.org/article/92008e3d96ee43a6bea7a4ee112b8108
Publikováno v:
Nature chemical biology
Spastin is a microtubule-severing AAA (ATPases associated with diverse cellular activities) protein needed for cell division and intracellular vesicle transport. Currently, we lack chemical inhibitors to probe spastin function in such dynamic cellula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbd6a1820210767bbf430c9a80e833a1
https://doi.org/10.1038/s41589-019-0225-6
https://doi.org/10.1038/s41589-019-0225-6
Publikováno v:
Nat Struct Mol Biol
The structural conservation across the AAA (ATPases associated with diverse cellular activities) protein family makes designing selective chemical inhibitors challenging. Here, we identify a triazolopyridine-based fragment that binds the AAA domain o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6376ca47128bcfe9ae07f4a5b52b29d
https://pubmed.ncbi.nlm.nih.gov/33782614
https://pubmed.ncbi.nlm.nih.gov/33782614
Publikováno v:
Cell Chem Biol
Summary Drug-like inhibitors are often designed by mimicking cofactor or substrate interactions with enzymes. However, as active sites are comprised of conserved residues, it is difficult to identify the critical interactions needed to design selecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad5fa450865ad8a2a6d3e0eafa7668d6
https://pubmed.ncbi.nlm.nih.gov/31257183
https://pubmed.ncbi.nlm.nih.gov/31257183
The bump-hole approach is a powerful chemical biology strategy to specifically probe the functions of closely related proteins. However, for many protein families, such as the ATPases associated with diverse cellular activities (AAA), we lack structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78cec0fb780905f70bbacdfff913d43b
https://europepmc.org/articles/PMC6637947/
https://europepmc.org/articles/PMC6637947/
Publikováno v:
SSRN Electronic Journal.
Drug-like inhibitors are often designed by mimicking cofactor or substrate interactions with enzymes. However, as active sites are comprised of conserved residues, it is difficult to identify the critical interactions needed to design selective inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::711bf372a33e6a73dad0b96d6a7a8cab
https://doi.org/10.2139/ssrn.3372968
https://doi.org/10.2139/ssrn.3372968
Autor:
Ruta Zalyte, Maxence V. Nachury, Andrew P. Carter, Rand M. Miller, Fan Ye, Tommaso Cupido, Jonathan B. Steinman, Andrew H. Chung, Tarun M. Kapoor, Sascha Hoogendoorn, Stephanie K. See, Tomoyo Sakata-Kato, James K. Chen
Publikováno v:
See, SK; Hoogendoorn, S; Chung, AH; Ye, F; Steinman, JB; Sakata-Kato, T; et al.(2016). Cytoplasmic Dynein Antagonists with Improved Potency and Isoform Selectivity. ACS CHEMICAL BIOLOGY, 11(1), 53-60. doi: 10.1021/acschembio.5b00895. UCSF: Retrieved from: http://www.escholarship.org/uc/item/3tn1x71x
ACS Chemical Biology
ACS Chemical Biology
Cytoplasmic dyneins 1 and 2 are related members of the AAA+ superfamily (ATPases associated with diverse cellular activities) that function as the predominant minus-end-directed microtubule motors in eukaryotic cells. Dynein 1 controls mitotic spindl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e614c706382fcdbda3f462817e70ee6c
https://doi.org/10.1021/acschembio.5b00895
https://doi.org/10.1021/acschembio.5b00895
Autor:
Javier Ruiz-Rodríguez, Jaume Adan, Jaume Piulats, Fernando Albericio, Jan Spengler, Tommaso Cupido, Francesc Mitjans
Publikováno v:
Angewandte Chemie. 122:2792-2797
Natural or designed peptide ligands rarely bind to cognate receptors in their most stable conformation when in solution. The receptor, through reciprocal induced fitting, applies pressure on the conformational ensemble of the peptide to select its co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::467b786d60bb27ada3458880d66d4e87
https://doi.org/10.1002/ange.200907274
https://doi.org/10.1002/ange.200907274
Autor:
Tommaso Cupido, Paul G. Rack, Ari J. Firestone, Joel M. Hyman, Kyuho Han, Surajit Sinha, Cory A. Ocasio, James K. Chen
Publikováno v:
Angewandte Chemie. 121:2357-2360
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e6754e288dd50bc7f1b389325417f67
https://doi.org/10.1002/ange.200805666
https://doi.org/10.1002/ange.200805666
Autor:
Surajit Sinha, Joel M. Hyman, Ari J. Firestone, James K. Chen, Kyuho Han, Cory A. Ocasio, Paul G. Rack, Tommaso Cupido
Publikováno v:
Angewandte Chemie International Edition. 48:2321-2324
Eradicating hedgehogs: The title molecule has been previously identified as a potent inhibitor of the Hedgehog signaling pathway, which gives embryonic cells information needed to develop properly. This molecule is shown to modulate Hedgehog target g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74d0a60c440abee5171e22fb75e21f98
https://doi.org/10.1002/anie.200805666
https://doi.org/10.1002/anie.200805666