Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Tomio Yamakawa"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Opioid addiction and the opioid overdose epidemic are becoming more serious, and the development of therapeutic agents is essential for the pharmacological treatment of substance use disorders. The κ-opioid receptor (KOP) is a member of the
Externí odkaz:
https://doaj.org/article/4f9c9cb4a3394d6bae338d3b6b6bc1f6
Autor:
Hiroshi Nagase, Shigeto Hirayama, Toshihiro Takahashi, Kohei Hayashida, Takashi Iwai, Yoshikazu Watanabe, Eriko Nakata, Saito Daisuke, Junichi Sakai, Takashi Kanda, Hideaki Fujii, Tomio Yamakawa
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(15)
We designed and synthesized novel δ opioid receptor (DOR) agonists 3a – i with an azatricyclodecane skeleton, which was a novel structural class of DOR agonists. Among them, 3b exhibited high values of binding affinity and potent agonistic activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d635dd8c01465c37cce531890169513b
https://pubmed.ncbi.nlm.nih.gov/28602640
https://pubmed.ncbi.nlm.nih.gov/28602640
Publikováno v:
Modern Rheumatology. 24:775-780
To evaluate the therapeutic efficacy of a novel inhibitor for IκB kinase alpha (IKKα), noraristeromycin (NAM), for murine experimental model of rheumatoid arthritis, collagen- induced arthritis (CIA).NAM has been chemically synthesized as reported
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff60536dd360f4faf25ac7e27c444426
https://doi.org/10.3109/14397595.2013.879416
https://doi.org/10.3109/14397595.2013.879416
Autor:
Toshihiro, Okamoto 1, Yoshihisa, Nakano 1, Tomio, Yamakawa 1, Kaoru, Hara 1, Ken-Ichi, Yamamura 2, Okio, Hino 3
Publikováno v:
In Japanese Journal of Pharmacology 1999 79(3):289-294
Autor:
Toshihiro Takahashi, Ikunobu Muramatsu, Tomio Yamakawa, Hidenori Umada, Akio Yamaguchi, Hatsumi Yoshiki, Tadashi Kobayashi, Osamu Yokoyama, Junsuke Uwada
Publikováno v:
British Journal of Pharmacology. 170:1242-1252
Background and Purpose Two distinct α1-adrenoceptor phenotypes (α1A and α1L) have recently been demonstrated to originate from a single α1A-adrenoceptor gene. Here, we examined the agonist profiles of recombinant α1A and α1L phenotypes and of l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::288f1ca0cebf6e7a62c20b37dabd605c
https://doi.org/10.1111/bph.12403
https://doi.org/10.1111/bph.12403
Publikováno v:
Letters in Drug Design & Discovery. 8:496-499
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd02d434a7de1883fe15fd4f7970f9e3
https://doi.org/10.2174/157018011795906802
https://doi.org/10.2174/157018011795906802
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:3255-3264
We discovered novel peroxisome proliferator-activated receptor δ agonists with a characteristic benzisoxazole ring. Compound 5 exhibited potent human PPARδ transactivation activity. Furthermore, it stimulated the differentiation of oligodendrocyte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbe81d5f45a89c11352061a80538d957
https://doi.org/10.1016/j.bmc.2011.03.053
https://doi.org/10.1016/j.bmc.2011.03.053
Publikováno v:
Journal of Dermatological Science. 86:e92
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ff73236d9645b83972a4b66015d8431
https://doi.org/10.1016/j.jdermsci.2017.02.269
https://doi.org/10.1016/j.jdermsci.2017.02.269
Publikováno v:
Journal of Manufacturing Science and Engineering. 121:313-320
A cone-type piercing mill was developed by the authors for materials with poor hot workability. This piercing mill is called “the super piercer” in Europe. It has a pair of cone-type main rolls supported at both ends with their roll axes inclined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d42400faacf25f230ebd3bcd92ef78b
https://doi.org/10.1115/1.2832683
https://doi.org/10.1115/1.2832683
Investigation on the Manufacturing Condition of Ti-6Al-4V Seamless Pipes by Inclined Rolling Process
Autor:
Tomio Yamakawa, Atsuhiko Kuroda
Publikováno v:
Tetsu-to-Hagane. 85:387-393
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b8a80aefabbe47f3f8d2ce922c29df4
https://doi.org/10.2355/tetsutohagane1955.85.5_387
https://doi.org/10.2355/tetsutohagane1955.85.5_387