Zobrazeno 1 - 10
of 275
pro vyhledávání: '"Tomio Okamura"'
Autor:
Masashi Tawa, Katsuya Nakano, Yuka Yamashita, Qiang He, Takayoshi Masuoka, Tomio Okamura, Takaharu Ishibashi
Publikováno v:
Pharmacology Research & Perspectives, Vol 9, Iss 4, Pp n/a-n/a (2021)
Abstract This study aimed to investigate how atherosclerosis affects the soluble guanylate cyclase (sGC) system in coronary arteries. Rabbits were fed a normal diet for 12 weeks (N group) or a diet containing high cholesterol (1%) for 4 weeks (S‐HC
Externí odkaz:
https://doaj.org/article/0829004e01484892b846003fa7e160c1
Autor:
Noboru Toda, Tomio Okamura
Publikováno v:
Journal of Pharmacological Sciences, Vol 131, Iss 4, Pp 223-232 (2016)
Cerebral blood flow is mainly regulated by nitrergic (parasympathetic, postganglionic) nerves and nitric oxide (NO) liberated from endothelial cells in response to shear stress and stretch of vasculature, whereas sympathetic vasoconstrictor control i
Externí odkaz:
https://doaj.org/article/18606cc0ac044fd2b9fbb9f7e6e6470a
Autor:
Kohji Nagayama, Katsutaro Morino, Osamu Sekine, Fumiyuki Nakagawa, Atsushi Ishikado, Hirotaka Iwasaki, Takashi Okada, Masashi Tawa, Daisuke Sato, Takeshi Imamura, Yoshihiko Nishio, Satoshi Ugi, Atsunori Kashiwagi, Tomio Okamura, Hiroshi Maegawa
Publikováno v:
Nutrients, Vol 7, Iss 9, Pp 8112-8126 (2015)
N-3 polyunsaturated fatty acids such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) have protective effects against atherosclerosis. Monocyte chemotactic protein (MCP)-1 is a major inflammatory mediator in the progression of atheroscle
Externí odkaz:
https://doaj.org/article/39e56ef7b4bc42a29a4aa0be74246365
Autor:
Masashi Tawa, Ayman Geddawy, Takashi Shimosato, Hirotaka Iwasaki, Takeshi Imamura, Tomio Okamura
Publikováno v:
Journal of Pharmacological Sciences, Vol 125, Iss 2, Pp 169-175 (2014)
Abstract.: Hypoxia or hypoxia/reoxygenation impairs nitric oxide (NO)-mediated relaxation through the increase in superoxide generation in monkey coronary arteries. Soluble guanylate cyclase (sGC), the target enzyme of NO, has been shown to change fr
Externí odkaz:
https://doaj.org/article/6d3ce29626e2430ea2c01f93daa2e517
Autor:
Tomio Okamura, Masashi Tawa, Ayman Geddawy, Takashi Shimosato, Hirotaka Iwasaki, Haruo Shintaku, Yuichi Yoshida, Masahiro Masada, Kazuya Shinozaki, Takeshi Imamura
Publikováno v:
Journal of Pharmacological Sciences, Vol 124, Iss 1, Pp 76-85 (2014)
Abstract.: Deficiency of tetrahydrobiopterin (BH4) in the vascular tissue contributes to endothelial dysfunction through reduced eNOS activity and increased superoxide anion (O2−) generation in the insulin-resistant state. We investigated the effec
Externí odkaz:
https://doaj.org/article/f1159cd23700444cb3ec2a36531b9a19
Autor:
Takehiro Yamaguchi, Takanori Yamazaki, Hiroaki Kawaguchi, Masashi Tawa, Yasuhiro Nakamura, Masayuki Shiota, Mayuko Osada-Oka, Akihide Tanimoto, Tomio Okamura, Katsuyuki Miura, Hiroshi Iwao, Minoru Yoshiyama, Yasukatsu Izumi
Publikováno v:
Journal of Pharmacological Sciences, Vol 126, Iss 2, Pp 168-171 (2014)
Abstract.: Metabolic syndrome (MetS) induces serious complications; therefore, we developed a noninvasive MetS model using an extremely small minipig, the Microminipig. For 8 weeks, Microminipigs were administrated a high-fat and high-cholesterol die
Externí odkaz:
https://doaj.org/article/a543766a6679448cbcd2f3c5d6059dcf
Publikováno v:
Journal of Pharmacological Sciences, Vol 118, Iss 2, Pp 205-214 (2012)
Cigarette smoking has been implicated in the initiation and progression of cardiovascular disorders and atherosclerosis. Here, we examined the effects of nicotine-free cigarette smoke extract (CSE) on the regulation of cardiovascular function. Rats w
Externí odkaz:
https://doaj.org/article/82c30d4c92414e838fc5a00bf71d7011
Autor:
Masashi Tawa, Kohei Yamamizu, Ayman Geddawy, Takashi Shimosato, Takeshi Imamura, Kazuhide Ayajiki, Tomio Okamura
Publikováno v:
Journal of Pharmacological Sciences, Vol 116, Iss 2, Pp 188-196 (2011)
Abstract.: To investigate the effect of hypoxia or hypoxia/reoxygenation on vascular smooth muscle function, mechanical response of monkey coronary artery without endothelium was studied under normoxia, hypoxia, and hypoxia/reoxygenation. Hypoxia or
Externí odkaz:
https://doaj.org/article/5300128eac37410db73dbf074aee6abf
Publikováno v:
Journal of Pharmacological Sciences, Vol 112, Iss 3, Pp 378-381 (2010)
We compared mechanical responses to uridine-5′triphosphate (UTP) and 2-(methylthio)adenosine-5′diphosphate (2MeSADP) of cerebral arteries isolated from dogs and monkeys. In the dog, UTP induced endothelium-independent contraction, whereas 2MeSADP
Externí odkaz:
https://doaj.org/article/e84b011d1d59402c90c3c5a1d9f1cfab
Publikováno v:
Journal of Pharmacological Sciences, Vol 114, Iss 2, Pp 180-188 (2010)
We recently reported endothelium-dependent relaxation caused by nucleotides in the non-human primate cerebral artery. Here, we investigated the endothelium-dependent, nitric oxide- and prostanoid-independent relaxation induced by 2-methylthio-ADP (2M
Externí odkaz:
https://doaj.org/article/4c53da3bcf824829ae2f30272d35b088