Zobrazeno 1 - 10
of 489
pro vyhledávání: '"Tomio Arai"'
Autor:
Tomoyasu Matsubara, Kenji Ishii, Yoko Saito, Aya Midori Tokumaru, Akira Arakawa, Manato Hara, Masanori Kurihara, Renpei Sengoku, Kazutomi Kanemaru, Atsushi Iwata, Tomio Arai, Akinori Miyashita, Takeshi Ikeuchi, Masato Hasegawa, Shigeo Murayama, Yuko Saito
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-4 (2024)
Externí odkaz:
https://doaj.org/article/8a51de4650cf4603b783f749acca242b
Autor:
Keisuke Nonaka, Kaiyo Takubo, Junko Aida, Yoriko Watai, Akiko Komatsu, Fujiya Gomi, Yuuki Shichi, Yuto Yamazaki, Toshiyuki Ishiwata, Hironobu Sasano, Tomio Arai
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
BackgroundThe number of patients with prolonged critical illness (PCI) has been increasing in many countries, and the adrenal gland plays an important role in maintaining homeostasis during PCI. Chronic disease burden is reportedly associated with sh
Externí odkaz:
https://doaj.org/article/8d3eff5b9ee346f5ba26e11f15240004
Autor:
Mika Hayakawa, Tomoyasu Matsubara, Yoko Mochizuki, Chisen Takeuchi, Motoyuki Minamitani, Masayuki Imai, Kenjiro Kosaki, Tomio Arai, Shigeo Murayama
Publikováno v:
BMC Neurology, Vol 22, Iss 1, Pp 1-9 (2022)
Abstract Background The detailed neuropathological features of patients with autosomal recessive hereditary spastic paraplegia with a thin corpus callosum (TCC) and SPG11 mutations are poorly understood, as only a few autopsies have been reported. He
Externí odkaz:
https://doaj.org/article/65737180a3ed4d4b824a504c07a51d85
Autor:
Toshio Fujisawa, Takayoshi Tsuchiya, Motohiko Kato, Masafumi Mizuide, Kazuki Takakura, Makoto Nishimura, Hiromu Kutsumi, Yoko Matsuda, Tomio Arai, Shomei Ryozawa, Takao Itoi, Hiroyuki Isayama, Hideyuki Saya, Naohisa Yahagi
Publikováno v:
EClinicalMedicine, Vol 55, Iss , Pp 101731- (2023)
Summary: Background: The impact of stroma-targeting therapy on tumor immune suppression is largely unexplored. An RNA oligonucleotide, STNM01, has been shown to repress carbohydrate sulfotransferase 15 (CHST15) responsible for tumor proteoglycan synt
Externí odkaz:
https://doaj.org/article/4601cb53f7b14cf0b7ab8e6cab0a0da5
Autor:
Yuuki Shichi, Fujiya Gomi, Yoshibumi Ueda, Keisuke Nonaka, Fumio Hasegawa, Yasuko Hasegawa, Nae Hinata, Hisashi Yoshimura, Masami Yamamoto, Kimimasa Takahashi, Tomio Arai, Toshiyuki Ishiwata
Publikováno v:
Biochemistry and Biophysics Reports, Vol 32, Iss , Pp 101339- (2022)
Three-dimensional (3D) culture of cancer cells mimics the in vivo environment. Recently, we reported that pancreatic ductal adenocarcinoma (PDAC) cell lines with epithelial and mesenchymal features formed differently shaped spheres in 3D culture. How
Externí odkaz:
https://doaj.org/article/5c005926cb2e4ad599fae0a0727a0d91
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 12, p 10184 (2023)
Adverse ventricular remodeling after myocardial infarction (MI) is progressive ventricular dilatation associated with heart failure for weeks or months and is currently regarded as the most critical sequela of MI. It is explained by inadequate tissue
Externí odkaz:
https://doaj.org/article/22007ec0d7884deea5fce34a65422264
Autor:
Norihiko Sasaki, Seiichi Shinji, Yuuki Shichi, Toshiyuki Ishiwata, Tomio Arai, Takeshi Yamada, Goro Takahashi, Ryo Ohta, Hiromichi Sonoda, Akihisa Matsuda, Takuma Iwai, Kohki Takeda, Kazuhide Yonaga, Koji Ueda, Sho Kuriyama, Toshimitsu Miyasaka, Hiroshi Yoshida
Publikováno v:
Biochemistry and Biophysics Reports, Vol 30, Iss , Pp 101239- (2022)
Epithelial–mesenchymal transition (EMT) plays a pivotal role in cancer progression and metastasis in many types of malignancies, including colorectal cancer. Although the importance of EMT is also considered in colorectal neuroendocrine carcinoma (
Externí odkaz:
https://doaj.org/article/67c15dce15f04150a384a2098a33d490
Autor:
Hikaru Sugimoto, Kensuke Yasue, Misako Hara, Shoichiro Takakuma, Wako Yumura, Tomio Arai, Kentaro Hayakawa, Fumiaki Tokimura, Tsuyoshi Miyazaki
Publikováno v:
Clinical Case Reports, Vol 9, Iss 4, Pp 1890-1895 (2021)
Abstract Obtaining a correct intraosseous epidermal cyst diagnosis is difficult due to the extreme rarity of this cyst. Further, the clinical manifestations and radiographic findings are very similar to those of a malignancy or infection. Early histo
Externí odkaz:
https://doaj.org/article/80cfe70a7b0c4be895655ede11616d4a
Autor:
Naoko Honma, Tomio Arai, Yoko Matsuda, Yosuke Fukunaga, Masaaki Muramatsu, Shinobu Ikeda, Yuri Akishima-Fukasawa, Noriko Yamamoto, Hiroshi Kawachi, Yuichi Ishikawa, Kengo Takeuchi, Tetuo Mikami
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4502 (2023)
The pathobiological role of estrogen is controversial in colorectal cancer. Cytosine-adenine (CA) repeat in the estrogen receptor (ER)-β gene (ESR2-CA) is a microsatellite, as well as representative of ESR2 polymorphism. Though its function is unkno
Externí odkaz:
https://doaj.org/article/861097f273b34f3cb54a9bb05823ffd3
Autor:
Maidina Abudushataer, Noriko Sato, Makiko Mieno, Motoji Sawabe, Masaaki Muramatsu, Tomio Arai
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-8 (2020)
Abstract Background CYP2A6 is an enzyme involved in oxidation of a number of environmental chemicals, including nicotine, pro-carcinogenic nitrosamines and polycyclic aromatic hydrocarbons (PAHs). The whole gene deletion of CYP2A6 (CYP2A6*4) is preva
Externí odkaz:
https://doaj.org/article/1081fc3f132643f5bb2d576930e5f1c1