Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Tomiki Hashiyama"'
Autor:
Tomiki Hashiyama, Kazutoshi Sugawara
Publikováno v:
Tetrahedron Letters. 48:3723-3726
Reaction of chiral cis - and trans -6-( tert -butyldimethylsilyloxy)-3,6-dihydro-2 H -pyran-3-yl acetates with various nucleophiles (allyltrimethylsilane, bistrimethylsilylacetylene, benzyl alcohol, benzyl carbamate etc.) in the presence of a Lewis a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cf9d9b02117e2ad260441a270a5eeee
https://doi.org/10.1016/j.tetlet.2007.03.104
https://doi.org/10.1016/j.tetlet.2007.03.104
Autor:
Tooru Kuroda, Tomiki Hashiyama, Masahiko Seki, Mari Kusama, Naoyuki Harada, Takeshi Yamanaka, Hiroaki Arakawa, Toshiyuki Furutani, Ritsuo Imashiro
Publikováno v:
Tetrahedron Letters. 42:8201-8205
A practical synthesis of methyl (2R,3S)-3-(4-methoxyphenyl)glycidate (−)-2a , a key intermediate for diltiazem ( 3 ), was described. Treatment of methyl (E)-4-methoxycinnamate (E)-1a with chiral dioxirane, generated in situ from a catalytic amount
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::588e302b6c9b3cb581875f40d452def4
https://doi.org/10.1016/s0040-4039(01)01762-2
https://doi.org/10.1016/s0040-4039(01)01762-2
Autor:
Maki Nishio, Tomiki Hashiyama, Kazutoshi Sugawara, Noriyuki Nakanishi, Naomitsu Hirano, Saburo Komatsubara, Jun Kohno
Publikováno v:
Tetrahedron. 57:1731-1735
A new antitumor antibiotic, TMC-69, possessing inhibitory activity against cdc25A phosphatase, has been isolated from the fermentation broth of a mitosporic fungus, Chrysosporium sp. TC 1068. This antibiotic was labile in solid state as well as in so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::274f6d621733d847869a7467fb193e44
https://doi.org/10.1016/s0040-4020(01)00009-6
https://doi.org/10.1016/s0040-4020(01)00009-6
Publikováno v:
Tetrahedron: Asymmetry. 11:4529-4535
Lipase catalyzed kinetic resolution of racemic cis-6-(tert-butyldimethylsilyloxy)-3,6-dihydro-2H-pyran-3-ol (rac)-1 was achieved in high enantiomeric excess. Transesterification of (rac)-1 with vinylacetate in tBuOMe yielded the alcohol (3S,6R)-1 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0881655a893ed09bbb68a34727dcd502
https://doi.org/10.1016/s0957-4166(00)00424-9
https://doi.org/10.1016/s0957-4166(00)00424-9
Autor:
Tetsuo Yamaguchi, Kunihiko Ozaki, Naoyuki Harada, Kouji Oda, Noriyuki Nakanishi, Hiroaki Arakawa, Kenji Tsujihara, Tomiki Hashiyama
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:1639-1644
A novel 3'-desphenyl-3'-cyclopropyl analogue of docetaxel was synthesized from 10-deacetyl-baccatin III. The cytotoxicity of the new taxoid was evaluated against several human tumor cell lines, and it had ca. 20 times stronger activity against human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b7ea4263445da6a5cf02099a903a1dd
https://doi.org/10.1016/s0960-894x(99)00257-7
https://doi.org/10.1016/s0960-894x(99)00257-7
Autor:
Tetsuo Yamaguchi, Masahito Hayashi, Hiroaki Arakawa, Tomiki Hashiyama, Naoyuki Harada, Kunihiko Ozaki
Publikováno v:
Tetrahedron. 55:1005-1016
A novel route to the synthesis of docetaxel using esterification of (2R,3R)- or (2R, 3S)-glycidic acid with 7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)-10-deacetylbaccatin III is described. Related novel taxoids which have new side chains were synthes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::951acbd6cf2cc09833156be15a8a600a
https://doi.org/10.1016/s0040-4020(98)01108-9
https://doi.org/10.1016/s0040-4020(98)01108-9
Autor:
Tomiki Hashiyama
Publikováno v:
Journal of Synthetic Organic Chemistry, Japan. 57:394-400
An efficient method for preparation of diltiazem hydrochloride, a representive calcium antagonist widely used for the treatment of ischemic heart disease all over the world, is described. In the reaction of 2-nitrothiophenol (1) with trans-3-phenylgl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::adf1b3a84516114f60ec2fc0b128a92b
https://doi.org/10.5059/yukigoseikyokaishi.57.394
https://doi.org/10.5059/yukigoseikyokaishi.57.394
Publikováno v:
Tetrahedron Letters. 39:5575-5578
A novel route for the synthesis of docetaxel ( 2 ) using esterification of (2 R , 3 R )-glycidic acid with 7,10-bis- O -(2,2,2-trichloroethoxycarbonyl)-10-deacetylbaccatin III is described. Subsequent stereo- and regio-selective conversion afforded 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee9518a712c34f92b0b698ebc2806178
https://doi.org/10.1016/s0040-4039(98)01124-1
https://doi.org/10.1016/s0040-4039(98)01124-1
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad9f8bcf6626ca952ed2e0a9e258d8e3
https://doi.org/10.1002/chin.199403062
https://doi.org/10.1002/chin.199403062
Autor:
Naoyuki Harada, Kenji Tsujihara, Motoaki Ohohashi, Tomiki Hashiyama, Takayuki Kawaguchi, Kouji Oda, Mitsuya Hongu
Publikováno v:
ChemInform. 27
In an attempt to improve the effectiveness of action of 5-fluoro-2'-deoxyuridine (FUdR), various kinds of O-alkylated water-soluble analogues were synthesized. Antitumor activities against sarcoma 180 (solid) were also evaluated. Some compounds exhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::025236485571b602eed8e63df1348f2b
https://doi.org/10.1002/chin.199647235
https://doi.org/10.1002/chin.199647235