Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Tomihisa Kawasaki"'
Publikováno v:
European Journal of Pharmacology. 798:72-76
Clopidogrel (Plavix®, Sanofi-Aventis), the adenosine diphosphate P2Y12 receptor antagonist, is reported to be effective in the prevention of cardiovascular events and is often used in combination with aspirin, particularly in high-risk patients. ASP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71c0afaa5c7d258d15356738504f0007
https://doi.org/10.1016/j.ejphar.2017.01.015
https://doi.org/10.1016/j.ejphar.2017.01.015
Autor:
Yoshiyuki Iwatsuki, Tomihisa Kawasaki, Chinatsu Sakata, Yumiko Moritani, Yoshiaki Morita, Hideaki Hara
Publikováno v:
Thrombosis research. 157
Introduction Percutaneous coronary interventions (PCIs), such as balloon angioplasty and stent placement, are effective in the treatment of coronary artery disease. PCI has drawbacks, however, including acute thrombosis after the procedure and resten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5008b8c98ade3849c7f5efe6ef2daec2
https://pubmed.ncbi.nlm.nih.gov/28700965
https://pubmed.ncbi.nlm.nih.gov/28700965
Autor:
Yoshiaki Morita, Chinatsu Sakata, Yasuko Kato, Tomihisa Kawasaki, Toshiyuki Funatsu, Masaki Abe, Ken-ichi Suzuki, Makoto Ohmiya, Masamichi Okada
Publikováno v:
Thrombosis Research. 132:56-62
Introduction Aspirin inhibits both the cyclooxygenase (COX)-1-dependent production of thromboxane A2 (TXA2) in platelets and COX-2-dependent production of anti-aggregatory prostaglandin I2 (PGI2) in vessel walls, resulting in “aspirin dilemma.” O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba6e5fd39ab996695605a7d4b442e19
https://doi.org/10.1016/j.thromres.2013.03.005
https://doi.org/10.1016/j.thromres.2013.03.005
Autor:
Minori Saitoh, Yoshiyuki Iwatsuki, Toshio Uemura, Ken-ichi Suzuki, Tomihisa Kawasaki, Toshiyuki Funatsu, Seiji Kaku
Publikováno v:
European Journal of Pharmacology. 699:40-47
The oral direct factor Xa inhibitor darexaban administered intraduodenally prevented venous thrombus formation in both rats and rabbits with no effect on bleeding. The indirect parenteral Factor Xa inhibitor fondaparinux exerted similar properties, o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::538af5c32cae5b4a9866355b322683a1
https://doi.org/10.1016/j.ejphar.2012.11.026
https://doi.org/10.1016/j.ejphar.2012.11.026
Autor:
Yuzo Matsumoto, Yuji Koga, Norio Seki, Kenichi Mori, Tsukasa Ishihara, Yumiko Moritani, Ryouta Shiraki, Takeshi Kadokura, Yoshiyuki Iwatsuki, Shuichi Sakamoto, Takeshi Shigenaga, Hiroyuki Koshio, Keizo Sugasawa, Shunichiro Hachiya, Fukushi Hirayama, Shin-ichi Tsukamoto, Tomihisa Kawasaki
Publikováno v:
Journal of Medicinal Chemistry. 54:8051-8065
Inhibitors of factor Xa (FXa), a crucial serine protease in the coagulation cascade, have attracted a great deal of attention as a target for developing antithrombotic agents. We previously reported findings from our optimization study of a high-thro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c8a6c40b5439d83acb06a80b263695a
https://doi.org/10.1021/jm200868m
https://doi.org/10.1021/jm200868m
Autor:
Tomihisa Kawasaki, Fukushi Hirayama, Yuji Koga, Keizo Sugasawa, Chinatsu Sakata, Shin Naganuma, Masaki Abe, Hiroyuki Itoh, Ken-ichi Suzuki
Publikováno v:
European Journal of Pharmacology. 650:58-63
Eltrombopag, an orally-active small molecule thrombopoietin (TPO) receptor agonist, was used for the first time in 2008 to treat patients with chronic idiopathic thrombocytopenic purpura. Here, we investigated the pharmacological effect of a new oral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5a59b4cd368612ed5a0d14f02d99102
https://doi.org/10.1016/j.ejphar.2010.09.072
https://doi.org/10.1016/j.ejphar.2010.09.072
Autor:
Tomihisa Kawasaki, Masaki Abe, Fukushi Hirayama, Ken-ichi Suzuki, Mari Fukushima-Shintani, Yoshiyuki Iwatsuki, Keizo Sugasawa
Publikováno v:
Experimental Hematology. 36:1337-1342
Objective AKR-501 (YM477) is an orally active thrombopoietin (TPO) receptor agonist that mimics the biological effect of TPO in vitro and in vivo. Here, we report that AKR-501 in combination with TPO has additive effect on megakaryocytopoiesis. Mater
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4971ceb0245d606c7ed53a5dcd231c8e
https://doi.org/10.1016/j.exphem.2008.04.020
https://doi.org/10.1016/j.exphem.2008.04.020
Publikováno v:
Biological and Pharmaceutical Bulletin. 30:1874-1877
A simple, quantitative, and reproducible model of lower limb ischemia was developed. Vascular injury was induced by ferric chloride (FeCl(3)) solution to the rat iliac artery, after which blood flow in all of the lower limbs were continuously monitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d481b9b7e7ee714b31e48a076fc9fdc5
https://doi.org/10.1248/bpb.30.1874
https://doi.org/10.1248/bpb.30.1874
Autor:
Tatsuya Niimi, Tsukasa Ishihara, Shuichi Sakamoto, Yumiko Sakai-Moritani, Fukushi Hirayama, Mitsuaki Ohta, Takeshi Shigenaga, Shin-ichi Tsukamoto, Masanori Miura, Norio Seki, Tomihisa Kawasaki, Takanori Koike, Minoru Okada
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:7688-7705
Inhibition of tissue factor/factor VIIa complex (TF/FVIIa) is an attractive strategy for antithrombotic therapies. We began with an investigation of a non-amidine TF/FVIIa inhibitor based on a modification of amidine compound 1. Optimization of the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b29cce60466331049c3f089bd2315c8
https://doi.org/10.1016/j.bmc.2006.08.010
https://doi.org/10.1016/j.bmc.2006.08.010
Autor:
Keiji Miyata, Kazumi Hayashi, Tomihisa Kawasaki, Tetsu Saito, Jun Takasaki, Yumiko Moritani, Masatoshi Taniguchi, Wataru Uchida, Toshio Uemura
Publikováno v:
British Journal of Pharmacology. 148:61-69
1 The effects of YM-254890, a specific Galpha(q/11) inhibitor, on platelet functions, thrombus formation under high-shear rate condition and femoral artery thrombosis in cynomolgus monkeys were investigated. 2 YM-254890 concentration dependently inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c02902a40dd0186b3df7d61def551a7
https://doi.org/10.1038/sj.bjp.0706711
https://doi.org/10.1038/sj.bjp.0706711