Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Tomihiko Chihara"'
Autor:
Toshiyuki Onogawa, Michiaki Tominaga, Yoshihisa Yamada, Toyoki Mori, Tomihiko Chihara, Shigeki Nakamura, Yoshitaka Yamamura, Tatsuya Yamashita, Youichi Yabuuchi
Publikováno v:
Hypertension. 23:200-204
We studied the hypotensive effects of OPC-21268, an orally effective nonpeptide vasopressin V1 receptor antagonist, in spontaneously hypertensive rats (SHR) and stroke-prone SHR (SHRSP). OPC-21268 was given intravenously to conscious, freely moving S
Autor:
Toshiyuki Onogawa, Hidenori Ogawa, Hisashi Miyamoto, Tomihiko Chihara, Toyoki Mori, Hiroshi Yamashita, Shigeki Nakamura, Michiaki Tominaga, Youichi Yabuuchi, Tatsuya Yamashita, Yoshitaka Yamamura, Tetsumi Hosokawa
Publikováno v:
British Journal of Pharmacology. 105:787-791
1. OPC-31260, a benzazepine derivative, has been studied for its ability to antagonize the binding of arginine vasopressin (AVP) to receptors in rat liver (V1) and kidney (V2) plasma membranes, for antagonism of the antidiuretic action of AVP in alco
Autor:
Tomihiko Chihara, Toshiyuki Onogawa, Toyoki Mori, Tatsuya Yamashita, Youichi Yabuuchi, Yoshitaka Yamamura, Shigeki Nakamura, Michiaki Tominaga
Publikováno v:
Japanese journal of pharmacology. 68(3)
We studied the antagonistic actions of OPC-21268 (1-{1-[4-(3-acetylaminopropoxy)-benzoyl]-4-piperidyl}-3, 4-dihydro-2(1H)-quinolinone) on the arginine vasopressin (AVP)-induced vasoconstrictor response in the spinally-anesthetized dog. OPC-21268 at d
Autor:
Hiroshi Yamashita, Kazumi Kondo, Michiaki Tominaga, Kenji Nakaya, Hisashi Miyamoto, Tomihiko Chihara, Hidenori Ogawa, Youichi Yabuuchi, Yoshitaka Yamamura, Toyoki Mori
Publikováno v:
Journal of medicinal chemistry. 36(14)
A series of compounds has been synthesized and demonstrated to be antagonists of V1 receptors both in vitro and in vivo. These compounds are structurally related to the 1-(4-piperidyl)-2(1H)-quinolinones, including OPC-21268, an orally bioavailable A
Autor:
Toshiyuki Onogawa, Yoshitaka Yamamura, Kazumi Kondo, Toyoki Mori, Michiaki Tominaga, Shigeki Nakamura, Youichi Yabuuchi, Hidenori Ogawa, Tomihiko Chihara
Publikováno v:
Science (New York, N.Y.). 252(5005)
An orally effective, nonpeptide, vasopressin V1 receptor antagonist, OPC-21268, has been identified. This compound selectively antagonized binding to the V1 subtype of the vasopressin receptor in a competitive manner. In vivo, the compound acted as a
Publikováno v:
Biochimica et biophysica acta. 1088(1)
Following the differentiation of 3T3-L1 fibroblasts by insulin/dexamethasone/methylisobutylxanthine, marked increases in cAMP levels by isoproterenol but not forskolin and in 2-deoxyglucose uptake by insulin occurred. Pertussis toxin-pretreatment pri
Autor:
Yoshitaka Yamamura, Yoshihisa Yamada, Tatsuya Yamashita, Toyoki Mori, Michiaki Tominaga, Shigeki Nakamura, Youichi Yabuuchi, Toshiyuki Onogawa, Tomihiko Chihara
Publikováno v:
Japanese Journal of Pharmacology. 61:275
Autor:
Toyoki Mori, Yoshitaka Yamamura, Youichi Yabuuchi, Hidenori Ogawa, Shioeki Nakamura, Michiaki Tominaga, Tomihiko Chihara, Toshiyuki Onogawa
Publikováno v:
Japanese Journal of Pharmacology. 58:66
Autor:
Michiaki Tominaga, Toshiyuki Onogawa, Tomihiko Chihara, Hidenori Ogawa, Toyoki Mori, Shigeki Nakamura, Youichi Yabuuchi, Tatsuya Yamashita, Yoshitaka Yamamura, Yoshihisa Yamada
Publikováno v:
Japanese Journal of Pharmacology. 58:195
Autor:
Michiaki Tominaga, Shigeki Nakamura, Toshiyuki Onogawa, Tatsuya Yamashita, Yoshitaka Yamamura, Toyoki Mori, Youichi Yabuuchi, Yoshihisa Yamada, Tomihiko Chihara
Publikováno v:
Japanese Journal of Pharmacology. 58:195