Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Tomi Suomi"'
Autor:
Inna Starskaia, Milla Valta, Sami Pietilä, Tomi Suomi, Sirpa Pahkuri, Ubaid Ullah Kalim, Omid Rasool, Emilie Rydgren, Heikki Hyöty, Mikael Knip, Riitta Veijola, Jorma Ilonen, Jorma Toppari, Johanna Lempainen, Laura L. Elo, Riitta Lahesmaa
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Previous studies have revealed heterogeneity in the progression to clinical type 1 diabetes in children who develop islet-specific antibodies either to insulin (IAA) or glutamic acid decarboxylase (GADA) as the first autoantibodies. Here, we
Externí odkaz:
https://doaj.org/article/b06e835f5b7a4485812aa6eb1125e943
Autor:
Santosh D. Bhosale, Robert Moulder, Tomi Suomi, Terhi Ruohtula, Jarno Honkanen, Suvi M. Virtanen, Jorma Ilonen, Laura L. Elo, Mikael Knip, Riitta Lahesmaa
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110048- (2024)
Summary: In-utero and dietary factors make important contributions toward health and development in early childhood. In this respect, serum proteomics of maturing infants can provide insights into studies of childhood diseases, which together with pe
Externí odkaz:
https://doaj.org/article/1aff96323d1c4fe6bd9ec5227cbeba38
Autor:
Tommi Välikangas, Tomi Suomi, Courtney E. Chandler, Alison J. Scott, Bao Q. Tran, Robert K. Ernst, David R. Goodlett, Laura L. Elo
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Longitudinal proteomics holds great promise for biomarker discovery, but the data interpretation has remained a challenge. Here, the authors evaluate several tools to detect longitudinal differential expression in proteomics data and introduce RolDE,
Externí odkaz:
https://doaj.org/article/b79a18593db04cd9a2786773cf4f290f
Autor:
Tomi Suomi, Inna Starskaia, Ubaid Ullah Kalim, Omid Rasool, Maria K. Jaakkola, Toni Grönroos, Tommi Välikangas, Caroline Brorsson, Gianluca Mazzoni, Sylvaine Bruggraber, Lut Overbergh, David Dunger, Mark Peakman, Piotr Chmura, Søren Brunak, Anke M. Schulte, Chantal Mathieu, Mikael Knip, Riitta Lahesmaa, Laura L. Elo, Pieter Gillard, Kristina Casteels, Lutgart Overbergh, Chris Wallace, Mark Evans, Ajay Thankamony, Emile Hendriks, Loredana Marcoveccchio, Timothy Tree, Noel G. Morgan, Sarah Richardson, John A. Todd, Linda Wicker, Adrian Mander, Colin Dayan, Mohammad Alhadj Ali, Thomas Pieber, Decio L. Eizirik, Myriam Cnop, Flemming Pociot, Jesper Johannesen, Peter Rossing, Cristina Legido Quigley, Roberto Mallone, Raphael Scharfmann, Christian Boitard, Timo Otonkoski, Riitta Veijola, Matej Oresic, Jorma Toppari, Thomas Danne, Anette G. Ziegler, Peter Achenbach, Teresa Rodriguez-Calvo, Michele Solimena, Ezio E. Bonifacio, Stephan Speier, Reinhard Holl, Francesco Dotta, Francesco Chiarelli, Piero Marchetti, Emanuele Bosi, Stefano Cianfarani, Paolo Ciampalini, Carine De Beaufort, Knut Dahl-Jørgensen, Torild Skrivarhaug, Geir Joner, Lars Krogvold, Przemka Jarosz-Chobot, Tadej Battelino, Bernard Thorens, Martin Gotthardt, Bart O. Roep, Tanja Nikolic, Arnaud Zaldumbide, Ake Lernmark, Marcus Lundgren, Guillaume Costacalde, Thorsten Strube, Almut Nitsche, Jose Vela, Matthias Von Herrath, Johnna Wesley, Antonella Napolitano-Rosen, Melissa Thomas, Nanette Schloot, Allison Goldfine, Frank Waldron-Lynch, Jill Kompa, Aruna Vedala, Nicole Hartmann, Gwenaelle Nicolas, Jean van Rampelbergh, Nicolas Bovy, Sanjoy Dutta, Jeannette Soderberg, Simi Ahmed, Frank Martin, Esther Latres, Gina Agiostratidou, Anne Koralova, Ruben Willemsen, Anne Smith, Binu Anand, Vipan Datta, Vijith Puthi, Sagen Zac-Varghese, Renuka Dias, Premkumar Sundaram, Bijay Vaidya, Catherine Patterson, Katharine Owen, Barbara Piel, Simon Heller, Tabitha Randell, Tasso Gazis, Elise Bismuth Reismen, Jean-Claude Carel, Jean-Pierre Riveline, Jean-Francoise Gautier, Fabrizion Andreelli, Florence Travert, Emmanuel Cosson, Alfred Penfornis, Catherine Petit, Bruno Feve, Nadine Lucidarme, Jean-Paul Beressi, Catherina Ajzenman, Alina Radu, Stephanie Greteau-Hamoumou, Cecile Bibal, Thomas Meissner, Bettina Heidtmann, Sonia Toni, Birgit Rami-Merhar, Bart Eeckhout, Bernard Peene, N. Vantongerloo, Toon Maes, Leen Gommers
Publikováno v:
EBioMedicine, Vol 92, Iss , Pp 104625- (2023)
Summary: Background: Type 1 diabetes is a complex heterogenous autoimmune disease without therapeutic interventions available to prevent or reverse the disease. This study aimed to identify transcriptional changes associated with the disease progress
Externí odkaz:
https://doaj.org/article/2c41bdea112542e1901b5cf0742fc2e4
Autor:
Astrid Oras, Henna Kallionpää, Tomi Suomi, Satu Koskinen, Asta Laiho, Laura L. Elo, Mikael Knip, Riitta Lahesmaa, Alar Aints, Raivo Uibo
Publikováno v:
Heliyon, Vol 9, Iss 2, Pp e13147- (2023)
Background: In coeliac disease (CoD), the role of B-cells has mainly been considered to be production of antibodies. The functional role of B-cells has not been analysed extensively in CoD. Methods: We conducted a study to characterize gene expressio
Externí odkaz:
https://doaj.org/article/94febd692ccf486ebc7319ba6a3af836
Autor:
Mikko S. Venäläinen, Eetu Heervä, Outi Hirvonen, Sohrab Saraei, Tomi Suomi, Toni Mikkola, Maarit Bärlund, Sirkku Jyrkkiö, Tarja Laitinen, Laura L. Elo
Publikováno v:
Cancer Medicine, Vol 11, Iss 3, Pp 654-663 (2022)
Abstract Background The existing risk prediction models for chemotherapy‐induced febrile neutropenia (FN) do not necessarily apply to real‐life patients in different healthcare systems and the external validation of these models are often lacking
Externí odkaz:
https://doaj.org/article/a4accec3641e4b499630a58b899048de
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 4870-4884 (2022)
Transcriptome level expression data connected to the spatial organization of the cells and molecules would allow a comprehensive understanding of how gene expression is connected to the structure and function in the biological systems. The spatial tr
Externí odkaz:
https://doaj.org/article/1589a23bad764c4ea6179c6efbde172f
Autor:
Pauliina M. Munne, Lahja Martikainen, Iiris Räty, Kia Bertula, Nonappa, Janika Ruuska, Hanna Ala-Hongisto, Aino Peura, Babette Hollmann, Lilya Euro, Kerim Yavuz, Linda Patrikainen, Maria Salmela, Juho Pokki, Mikko Kivento, Juho Väänänen, Tomi Suomi, Liina Nevalaita, Minna Mutka, Panu Kovanen, Marjut Leidenius, Tuomo Meretoja, Katja Hukkinen, Outi Monni, Jeroen Pouwels, Biswajyoti Sahu, Johanna Mattson, Heikki Joensuu, Päivi Heikkilä, Laura L. Elo, Ciara Metcalfe, Melissa R. Junttila, Olli Ikkala, Juha Klefström
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Reliable luminal estrogen receptor (ERα+) breast cancer models are limited. Here, the authors use patient derived breast epithelial and breast cancer explant cultures grown in several extracellular matrix scaffolds and show that ERα expression is r
Externí odkaz:
https://doaj.org/article/b09c6053c2ba40338196b223c9534247
Autor:
Tommi Välikangas, Sini Junttila, Kalle T. Rytkönen, Anu Kukkonen-Macchi, Tomi Suomi, Laura L. Elo
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
The coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is spreading across the world despite vast global vaccination efforts. Consequently, many studies have looked for potential human host
Externí odkaz:
https://doaj.org/article/367976d8dab74a4e87e379a4df86ddcc
Autor:
Tomi Suomi, Laura L. Elo
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Abstract We describe a new reproducibility-optimization method ROPECA for statistical analysis of proteomics data with a specific focus on the emerging data-independent acquisition (DIA) mass spectrometry technology. ROPECA optimizes the reproducibil
Externí odkaz:
https://doaj.org/article/7935f0467ab84c5385fae58ec6731df8