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pro vyhledávání: '"Tomi Luan"'
Autor:
Abbot F. Clark, Tomi Luan, Tasneem Putliwala, Iok-Hou Pang, Robert J. Wordinger, Colleen M McDowell, J. Cameron Millar, Simon W. M. John, Zhang Zhang
Publikováno v:
Experimental Eye Research. 100:65-72
Elevated intraocular pressure (IOP) is a causative risk factor for the development and progression of glaucoma. Glaucomatous mutations in myocilin (MYOC) damage the trabecular meshwork and elevate IOP in humans and in mice. Animal models of glaucoma
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose The trabecular meshwork (TM) is involved in the outflow of aqueous humor and intraocular pressure (IOP) regulation. Regulation of the extracellular matrix (ECM) by TGFβ2 signaling pathways in the TM has been extensively studied. Recent evide