Zobrazeno 1 - 10
of 235
pro vyhledávání: '"Tomi K, Sawyer"'
Autor:
Arun Chandramohan, Hubert Josien, Tsz Ying Yuen, Ruchia Duggal, Diana Spiegelberg, Lin Yan, Yu-Chi Angela Juang, Lan Ge, Pietro G. Aronica, Hung Yi Kristal Kaan, Yee Hwee Lim, Andrea Peier, Brad Sherborne, Jerome Hochman, Songnian Lin, Kaustav Biswas, Marika Nestor, Chandra S. Verma, David P. Lane, Tomi K. Sawyer, Robert Garbaccio, Brian Henry, Srinivasaraghavan Kannan, Christopher J. Brown, Charles W. Johannes, Anthony W. Partridge
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Although stapled α-helical peptides can address challenging targets, their advancement is impeded by poor understandings for making them cell permeable while avoiding off-target toxicities. By synthesizing >350 molecules, we present workflo
Externí odkaz:
https://doaj.org/article/244b34e3aef44b508696598d0927724f
Autor:
Anton V. Malyshev, Vsevolod V. Pavshintcev, Nikita A. Mitkin, Iuliia A. Sukhanova, Vasilina R. Gedzun, Alexander S. Zlobin, Igor I. Doronin, Gennady A. Babkin, Tomi K. Sawyer
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 18 (2024)
We employed a structural bioinformatics approach to develop novel peptides with predicted affinity to the binding site for negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGluR5). Primary screening in zebrafish (Danio reri
Externí odkaz:
https://doaj.org/article/76cf2f54874a4026980726e84e360222
Autor:
Margaret C. Frame, Tomi K. Sawyer, Chester A. Metcalf, Bryan Serrels, Valerie J. Fincham, Egle Avizienyte, Valerie G. Brunton
Supplementary video for Fig. 2A (SrcMF panels) from Identification of Src-Specific Phosphorylation Site on Focal Adhesion Kinase: Dissection of the Role of Src SH2 and Catalytic Functions and Their Consequences for Tumor Cell Behavior
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb2749aef911ff8e3c391c1c831c1d7
https://doi.org/10.1158/0008-5472.22365311.v1
https://doi.org/10.1158/0008-5472.22365311.v1
Autor:
Margaret C. Frame, Tomi K. Sawyer, Chester A. Metcalf, Bryan Serrels, Valerie J. Fincham, Egle Avizienyte, Valerie G. Brunton
Supplementary video for Fig. 3C from Identification of Src-Specific Phosphorylation Site on Focal Adhesion Kinase: Dissection of the Role of Src SH2 and Catalytic Functions and Their Consequences for Tumor Cell Behavior
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c3948ec1553e4d3bc256cb032224511
https://doi.org/10.1158/0008-5472.22365308
https://doi.org/10.1158/0008-5472.22365308
Autor:
Margaret C. Frame, Tomi K. Sawyer, Chester A. Metcalf, Bryan Serrels, Valerie J. Fincham, Egle Avizienyte, Valerie G. Brunton
Src tyrosine kinase expression and activity are elevated during colon cancer progression. How this contributes to the malignant phenotype is not fully understood. We show that in KM12C colon carcinoma cells, expression of kinase-deficient Src protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0838a9b5dff6a28ae13383bd4f01cf71
https://doi.org/10.1158/0008-5472.c.6494636
https://doi.org/10.1158/0008-5472.c.6494636
Autor:
Kristal Kaan, Nicole Boo, Yu-Chi Angela Juang, Chandra S. Verma, Kaustav Biswas, Ruchia Duggal, Christopher J. Brown, Bhvana Bhatt, Chunhui Huang, Simon Ng, Ahmad Sadruddin, Nianyu Jason Li, Srinivasaraghavan Kannan, Shuhui Lim, Xiang Yu, Charles W. Johannes, Andrea M. Peier, Anthony W. Partridge, Erjia Wang, Lan Ge, Michael Garrigou, Pooja Gopal, Gireedhar Venkatachalam, Brian Henry, Nicolas Boyer, Khong Ming Peh, Tsz Ying Yuen, Raymond J. Gonzalez, Feifei Chen, Tomi K. Sawyer, Alexander Stoeck, Peter Orth, David P. Lane
Publikováno v:
Chemical Science
Macrocyclic peptides have the potential to address intracellular protein–protein interactions (PPIs) of high value therapeutic targets that have proven largely intractable to small molecules. Here, we report broadly applicable lessons for applying
Autor:
Tomi K. Sawyer, Kaustav Biswas
Publikováno v:
ACS Symposium Series ISBN: 9780841297616
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffc76c1fa2e8729c662edff900b20896
https://doi.org/10.1021/bk-2022-1417.ch001
https://doi.org/10.1021/bk-2022-1417.ch001
Autor:
Charles W. Johannes, Dawn Thean, Joe R Cannon, Raymond Evers, Tanvi Desai, Hung Yi Kristal Kaan, David P. Lane, Christopher J. Brown, Ahmad Sadruddin, Anthony W. Partridge, Tsz Ying Yuen, Arun Chandramohan, Tomi K. Sawyer, Jerome Hochman, Bahanu Habulihaz
Publikováno v:
Pharmaceutical Research. 38:843-850
To develop a novel, target agnostic liposome click membrane permeability assay (LCMPA) using liposome encapsulating copper free click reagent dibenzo cyclooctyne biotin (DBCO-Biotin) to conjugate azido modified peptides that may effectively transloca
Autor:
Anthony W. Partridge, Hung Yi Kristal Kaan, Yu-Chi Juang, Ahmad Sadruddin, Shuhui Lim, Christopher J. Brown, Simon Ng, Dawn Thean, Fernando Ferrer, Charles Johannes, Tsz Ying Yuen, Srinivasaraghavan Kannan, Pietro Aronica, Yaw Sing Tan, Mohan R. Pradhan, Chandra S. Verma, Jerome Hochman, Shiying Chen, Hui Wan, Sookhee Ha, Brad Sherborne, David P. Lane, Tomi K. Sawyer
Publikováno v:
Molecules, Vol 24, Iss 12, p 2292 (2019)
Stapled α-helical peptides represent an emerging superclass of macrocyclic molecules with drug-like properties, including high-affinity target binding, protease resistance, and membrane permeability. As a model system for probing the chemical space
Externí odkaz:
https://doaj.org/article/76dd0b05d6584b64a066db0da685651e
Autor:
Luis E, Gimenez, Terry A, Noblin, Savannah Y, Williams, Satarupa, Mullick Bagchi, Ren-Lei, Ji, Ya-Xiong, Tao, Claus B, Jeppesen, Kilian W, Conde-Frieboes, Tomi K, Sawyer, Paolo, Grieco, Roger D, Cone
Publikováno v:
Journal of medicinal chemistry. 65(8)
Melanocortin peptides containing a 3-(2-naphthyl)-d-alanine residue in position 7 (DNal(2')