Zobrazeno 1 - 10
of 1 076
pro vyhledávání: '"Tomer M"'
Autor:
Yuqin Wu, Ashish Foollee, Andrea Y. Chan, Susanne Hille, Jana Hauke, Matthew P. Challis, Jared L. Johnson, Tomer M. Yaron, Victoria Mynard, Okka H. Aung, Maria Almira S. Cleofe, Cheng Huang, Terry C. C. Lim Kam Sian, Mohammad Rahbari, Suchira Gallage, Mathias Heikenwalder, Lewis C. Cantley, Ralf B. Schittenhelm, Luke E. Formosa, Greg C. Smith, Jürgen G. Okun, Oliver J. Müller, Patricia M. Rusu, Adam J. Rose
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The peptide hormone glucagon is a fundamental metabolic regulator that is also being considered as a pharmacotherapeutic option for obesity and type 2 diabetes. Despite this, we know very little regarding how glucagon exerts its pleiotropic
Externí odkaz:
https://doaj.org/article/2996febe0d924ecca6c4254d1c0d96ef
Publikováno v:
Forum of Mathematics, Pi, Vol 12 (2024)
We develop a general theory of higher semiadditive Fourier transforms that includes both the classical discrete Fourier transform for finite abelian groups at height $n=0$ , as well as a certain duality for the $E_n$ -(co)homology of $\pi $ -fi
Externí odkaz:
https://doaj.org/article/cafadc29aa9b4272835e50f88ee040ae
Autor:
Ting-Yu Lin, Shakti Ramsamooj, Tiffany Perrier, Katarina Liberatore, Louise Lantier, Neil Vasan, Kannan Karukurichi, Seo-Kyoung Hwang, Edward A. Kesicki, Edward R. Kastenhuber, Thorsten Wiederhold, Tomer M. Yaron, Emily M. Huntsman, Mengmeng Zhu, Yilun Ma, Marcia N. Paddock, Guoan Zhang, Benjamin D. Hopkins, Owen McGuinness, Robert E. Schwartz, Baran A. Ersoy, Lewis C. Cantley, Jared L. Johnson, Marcus D. Goncalves
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113535- (2023)
Summary: The phosphoinositide 3-kinase p110α is an essential mediator of insulin signaling and glucose homeostasis. We interrogated the human serine, threonine, and tyrosine kinome to search for novel regulators of p110α and found that the Hippo ki
Externí odkaz:
https://doaj.org/article/a5e7df93b0a7464587f421f871a959bf
Autor:
Stefano Suzzi, Tommaso Croese, Adi Ravid, Or Gold, Abbe R. Clark, Sedi Medina, Daniel Kitsberg, Miriam Adam, Katherine A. Vernon, Eva Kohnert, Inbar Shapira, Sergey Malitsky, Maxim Itkin, Alexander Brandis, Tevie Mehlman, Tomer M. Salame, Sarah P. Colaiuta, Liora Cahalon, Michal Slyper, Anna Greka, Naomi Habib, Michal Schwartz
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Obesity and aging increase Alzheimer’s disease (AD) risk. Here, using an AD mouse model and high-fat diet, we suggest that immune exhaustion links the two risk factors, and identify a metabolite that can hasten immune dysfunction and memory deficit
Externí odkaz:
https://doaj.org/article/f63e1c3be52546e8ab1f362761e300d0
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Competent T-cells with sufficient levels of fitness combat cancer formation and progression. In multiple myeloma (MM), T-cell exhaustion is caused by several factors including tumor burden, constant immune activation due to chronic disease, age, nutr
Externí odkaz:
https://doaj.org/article/ba51e21c53824109807983fc6abda806
Autor:
Christina A. Higgins, Benjamin E. Nilsson-Payant, Boris Bonaventure, Andrew P. Kurland, Chengjin Ye, Tomer M. Yaron, Jared L. Johnson, Prithy Adhikary, Ilona Golynker, Maryline Panis, Oded Danziger, Brad R. Rosenberg, Lewis C. Cantley, Luis Martínez-Sobrido, Benjamin tenOever, Jeffrey R. Johnson
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the coronavirus disease 2019 (COVID-19) pandemic, drastically modifies infected cells to optimize virus replication. One such modification is the activation
Externí odkaz:
https://doaj.org/article/f4d8484e81a64893a39af20ce68f7785
Autor:
Margaret E. Stalker, Tomer M. Mark
Publikováno v:
Current Oncology, Vol 29, Iss 7, Pp 4464-4477 (2022)
Major progress has been made in the upfront treatment of multiple myeloma, but the disease ultimately relapses and leads to death in the vast majority of those afflicted. New treatment strategies and modalities are necessary to treat myeloma in relap
Externí odkaz:
https://doaj.org/article/2c585c0ee72243a0a16c81cb5c9d1aa5
Autor:
Avishai Gavish, Benny Chain, Tomer M. Salame, Yaron E. Antebi, Shir Nevo, Shlomit Reich-Zeliger, Nir Friedman
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105826- (2023)
Summary: Numerous methods have recently emerged for ordering single cells along developmental trajectories. However, accurate depiction of developmental dynamics can only be achieved after rescaling the trajectory according to the relative time spent
Externí odkaz:
https://doaj.org/article/7fc9395b64ad45d9a7910ff3206b36d0
Publikováno v:
Clinical Case Reports, Vol 10, Iss 9, Pp n/a-n/a (2022)
Abstract Lenalidomide is an IMiD drug which has been associated with a variety of potential immune related complications. We describe the case of a patient with newly diagnosed multiple myeloma along with a history of systemic mastocytosis who develo
Externí odkaz:
https://doaj.org/article/c7e8a5dfa49440f1a7019de69e1a5b48
Autor:
Lauren T. Reiman, Zachary J. Walker, Lyndsey R. Babcock, Peter A. Forsberg, Tomer M. Mark, Daniel W. Sherbenou
Publikováno v:
Aging and Cancer, Vol 2, Iss 1-2, Pp 6-12 (2021)
Abstract The treatment of older persons with cancer is fraught by a delicate balance of targeting the disease while avoiding treatment‐related complications. “Personalized,” or “precision” medicine approaches can ease this problem through m
Externí odkaz:
https://doaj.org/article/925f760277ae49f193a8dcd6e13f00fa