Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Tomer Itkin"'
Autor:
Brandon Hadland, Barbara Varnum-Finney, Stacey Dozono, Tessa Dignum, Cynthia Nourigat-McKay, Adam M. Heck, Takashi Ishida, Dana L. Jackson, Tomer Itkin, Jason M. Butler, Shahin Rafii, Cole Trapnell, Irwin D. Bernstein
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Here, the authors use single cell RNA-sequencing to generate an atlas of signaling interactions regulating embryonic hematopoietic stem cell (HSC) development and apply this knowledge to engineer a niche sufficient to support HSC maturation in vitro.
Externí odkaz:
https://doaj.org/article/20905f69c37543e4b5a99130d19e5860
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Externí odkaz:
https://doaj.org/article/08911300c886462ca5d875f01c80fa70
Autor:
Eman Khatib-Massalha, Suditi Bhattacharya, Hassan Massalha, Adi Biram, Karin Golan, Orit Kollet, Anju Kumari, Francesca Avemaria, Ekaterina Petrovich-Kopitman, Shiri Gur-Cohen, Tomer Itkin, Isabell Brandenburger, Asaf Spiegel, Ziv Shulman, Zachary Gerhart-Hines, Shalev Itzkovitz, Matthias Gunzer, Stefan Offermanns, Ronen Alon, Amiram Ariel, Tsvee Lapidot
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Lactate is a by-product of glycolysis that can function via its G protein receptor GPR81. Here the authors show that LPS or Salmonella infection enhances glycolytic metabolism in bone marrow neutrophils, resulting in lactate production, which increas
Externí odkaz:
https://doaj.org/article/fd9905e2c6a74145a36f74cbae797fa7
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The bone marrow (BM) tissue is the main physiological site for adult hematopoiesis. In recent years, the cellular and matrix components composing the BM have been defined with unprecedent resolution, both at the molecular and structural levels. With
Externí odkaz:
https://doaj.org/article/6f540c2e963d44c6b0122546701c2092
Autor:
Jesus M. Gomez-Salinero, Tomer Itkin, Sean Houghton, Chaitanya Badwe, Yang Lin, Viktoria Kalna, Neil Dufton, Claire R. Peghaire, Masataka Yokoyama, Matthew Wingo, Tyler M. Lu, Ge Li, Jenny Zhaoying Xiang, Yen-Michael Sheng Hsu, David Redmond, Ryan Schreiner, Graeme M. Birdsey, Anna M. Randi, Shahin Rafii
Publikováno v:
Nat Cardiovasc Res
Current dogma dictates that, during adulthood, endothelial cells (ECs) are locked in an immutable stable homeostatic state. By contrast, herein we show that maintenance of EC fate and function are linked and active processes, which depend on the cons
Autor:
Aleksandr Sarachakov, Arina Varlamova, Viktor Svekolkin, Ilia Galkin, Itzel Valencia, Caitlin Unkenholz, Tania Pannellini, Aida Akaeva, Sofia Smirnova, Pavel Ovcharov, Margarita Polyakova, Dmitrii Tabakov, Ekaterina Postovalova, Isha Sethi, Nara Shin, Alexander Bagaev, Tomer Itkin, Genevieve Crane, Michael Kluk, Julia Geyer, Giorgio Inghirami, Sanjay Patel
The spatial anatomy of hematopoiesis in bone marrow has been extensively studied in mice and other preclinical models, but technical challenges have precluded a commensurate exploration in humans. Institutional pathology archives contain thousands of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25da2130f6635b86c7b7b6a8402a7c96
https://doi.org/10.1101/2023.04.28.538715
https://doi.org/10.1101/2023.04.28.538715
Autor:
Tomer Itkin, Shahin Rafii
Publikováno v:
Nature. 601:515-517
Autor:
Asaf Spiegel, Hassan Massalha, Shalev Itzkovitz, Orit Kollet, Eman Khatib-Massalha, Isabell Brandenburger, Suditi Bhattacharya, Francesca Avemaria, Ronen Alon, Ziv Shulman, Zachary Gerhart-Hines, Amiram Ariel, Tsvee Lapidot, Tomer Itkin, Adi Biram, Karin Golan, Ekaterina Petrovich-Kopitman, Anju Kumari, Stefan Offermanns, Matthias Gunzer, Shiri Gur-Cohen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications
Khatib-Massalha, E, Bhattacharya, S, Massalha, H, Biram, A, Golan, K, Kollet, O, Kumari, A, Avemaria, F, Petrovich-Kopitman, E, Gur-Cohen, S, Itkin, T, Brandenburger, I, Spiegel, A, Shulman, Z, Gerhart-Hines, Z, Itzkovitz, S, Gunzer, M, Offermanns, S, Alon, R, Ariel, A & Lapidot, T 2020, ' Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling ', Nature Communications, vol. 11, no. 1, 3547 . https://doi.org/10.1038/s41467-020-17402-2
Nature Communications
Khatib-Massalha, E, Bhattacharya, S, Massalha, H, Biram, A, Golan, K, Kollet, O, Kumari, A, Avemaria, F, Petrovich-Kopitman, E, Gur-Cohen, S, Itkin, T, Brandenburger, I, Spiegel, A, Shulman, Z, Gerhart-Hines, Z, Itzkovitz, S, Gunzer, M, Offermanns, S, Alon, R, Ariel, A & Lapidot, T 2020, ' Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling ', Nature Communications, vol. 11, no. 1, 3547 . https://doi.org/10.1038/s41467-020-17402-2
Neutrophils provide first line of host defense against bacterial infections utilizing glycolysis for their effector functions. How glycolysis and its major byproduct lactate are triggered in bone marrow (BM) neutrophils and their contribution to neut
Autor:
Peipei Guo, Ying Liu, Fuqiang Geng, Andrew W. Daman, Xiaoyu Liu, Liangwen Zhong, Arjun Ravishankar, Raphael Lis, José Gabriel Barcia Durán, Tomer Itkin, Fanying Tang, Tuo Zhang, Jenny Xiang, Koji Shido, Bi-sen Ding, Duancheng Wen, Steven Z. Josefowicz, Shahin Rafii
Publikováno v:
Nat Cell Biol
Histone variants and the associated post-translational modifications that govern the stemness of haematopoietic stem cells (HSCs) and differentiation thereof into progenitors (HSPCs) have not been well defined. H3.3 is a replication-independent H3 hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb3c30a0d7bddbe92d62db2c8d22adda
https://europepmc.org/articles/PMC9166935/
https://europepmc.org/articles/PMC9166935/
Autor:
Peipei Guo, Ying Liu, Fuqiang Geng, Andrew W. Daman, Xiaoyu Liu, Liangwen Zhong, Arjun Ravishankar, Raphael Lis, José Gabriel Barcia Durán, Tomer Itkin, Fanying Tang, Tuo Zhang, Jenny Xiang, Koji Shido, Bi-sen Ding, Duancheng Wen, Steven Z. Josefowicz, Shahin Rafii
Publikováno v:
Nature Cell Biology. 24:279-279