Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Tomer‐Meir Salame"'
Autor:
Arturo Simoni-Nieves, Moshit Lindzen, Suvendu Giri, Nitin Gupta, Rishita Chatterjee, Boobash-Raj Selvadurai, Marieke Van Daele, Danielle Love, Yuya Haga, Donatella Romaniello, Tomer-Meir Salame, Mirie Zerbib, Roni Oren, Yasuo Tsutsumi, Mattia Lauriola, Ilaria Marrocco, Yosef Yarden
Publikováno v:
Cell Reports Medicine, Vol 5, Iss 9, Pp 101703- (2024)
Summary: Activating EGFR (epidermal growth factor receptor) mutations can be inhibited by specific tyrosine kinase inhibitors (TKIs), which have changed the landscape of lung cancer therapy. However, due to secondary mutations and bypass receptors, s
Externí odkaz:
https://doaj.org/article/92b1210a06874d6d8474c3fe51ec1d80
Autor:
Hila Ben-Yehuda, Michal Arad, Javier María Peralta Ramos, Efrat Sharon, Giulia Castellani, Shir Ferrera, Liora Cahalon, Sarah Phoebeluc Colaiuta, Tomer-Meir Salame, Michal Schwartz
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-19 (2021)
Abstract Background For decades, dementia has been characterized by accumulation of waste in the brain and low-grade inflammation. Over the years, emerging studies highlighted the involvement of the immune system in neurodegenerative disease emergenc
Externí odkaz:
https://doaj.org/article/c67c798d41ae4a88aa38025c1555b9ea
Publikováno v:
PLoS ONE, Vol 17, Iss 6 (2022)
Mammary epithelial stem cells differentiate to create the basal and luminal layers of the gland. Inducing the number of differentiating bovine mammary stem cells may provide compensating populations for the milk-producing cells that die during lactat
Externí odkaz:
https://doaj.org/article/22a00c26d55c48dd981f57ab7971d2cc
Upfront admixing antibodies and EGFR inhibitors preempts sequential treatments in lung cancer models
Autor:
Ilaria Marrocco, Donatella Romaniello, Itay Vaknin, Diana Drago‐Garcia, Roni Oren, Mary Luz Uribe, Nishanth Belugali Nataraj, Soma Ghosh, Raya Eilam, Tomer‐Meir Salame, Moshit Lindzen, Yosef Yarden
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 4, Pp n/a-n/a (2021)
Abstract Some antibacterial therapies entail sequential treatments with different antibiotics, but whether this approach is optimal for anti‐cancer tyrosine kinase inhibitors (TKIs) remains open. EGFR mutations identify lung cancer patients who can
Externí odkaz:
https://doaj.org/article/f40e6d84396d426eb6294535a2d589ba
Autor:
Shiri Kult, Tsviya Olender, Marco Osterwalder, Svetalana Markman, Dena Leshkowitz, Sharon Krief, Ronnie Blecher-Gonen, Shani Ben-Moshe, Lydia Farack, Hadas Keren-Shaul, Tomer-Meir Salame, Terence D Capellini, Shalev Itzkovitz, Ido Amit, Axel Visel, Elazar Zelzer
Publikováno v:
eLife, Vol 10 (2021)
The mechanical challenge of attaching elastic tendons to stiff bones is solved by the formation of a unique transitional tissue. Here, we show that murine tendon-to-bone attachment cells are bi-fated, activating a mixture of chondrocyte and tenocyte
Externí odkaz:
https://doaj.org/article/d634c0b6552b4485bd6640c59f2a7db5
Autor:
Mor Gross-Vered, Sébastien Trzebanski, Anat Shemer, Biana Bernshtein, Caterina Curato, Gil Stelzer, Tomer-Meir Salame, Eyal David, Sigalit Boura-Halfon, Louise Chappell-Maor, Dena Leshkowitz, Steffen Jung
Publikováno v:
eLife, Vol 9 (2020)
Monocytes are circulating short-lived macrophage precursors that are recruited on demand from the blood to sites of inflammation and challenge. In steady state, classical monocytes give rise to vasculature-resident cells that patrol the luminal side
Externí odkaz:
https://doaj.org/article/e96cce39c2094bb2adfd4b8d40bac553
Publikováno v:
Cell Reports, Vol 20, Iss 11, Pp 2547-2555 (2017)
Cytotoxic T lymphocytes (CTLs) used in immunotherapy are typically cultured under atmospheric O2 pressure but encounter hypoxic conditions inside tumors. Activating CTLs under hypoxic conditions has been shown to improve their cytotoxicity in vitro,
Externí odkaz:
https://doaj.org/article/b5f95c053c15469b8b6dbdd9540b0443
Autor:
Anat Gershoni, Ori Hassin, Nishanth Belugali Nataraj, Sivan Baruch, Adi Avioz‐Seligman, Anna Chiara Pirona, Liat Fellus‐Alyagor, Tomer Meir Salame, Saptaparna Mukherjee, Giuseppe Mallel, Yosef Yarden, Yael Aylon, Moshe Oren
Publikováno v:
Molecular Oncology, Vol 17, Iss 12, Pp 2675-2693 (2023)
The core Hippo pathway module consists of a tumour‐suppressive kinase cascade that inhibits the transcriptional coactivators Yes‐associated protein (YAP) and WW domain‐containing transcription regulator protein 1 (WWTR1; also known as TAZ). Whe
Externí odkaz:
https://doaj.org/article/2dbf7e08c0fc4450b4c84ececd4af0cb
Autor:
Yael Aylon, Noa Furth, Giuseppe Mallel, Gilgi Friedlander, Nishanth Belugali Nataraj, Meng Dong, Ori Hassin, Rawan Zoabi, Benjamin Cohen, Vanessa Drendel, Tomer Meir Salame, Saptaparna Mukherjee, Nofar Harpaz, Randy Johnson, Walter E. Aulitzky, Yosef Yarden, Efrat Shema, Moshe Oren
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
LATS1 is reported to regulate the transition of luminal-basal-like cell plasticity in breast cancer. Here the authors report that LATS1 limits the progression of luminal breast cancer by associating with NCOR1 nuclear corepressor to repress ERα-down
Externí odkaz:
https://doaj.org/article/4ccbb8ac8c2f4c92a83690814f9d6056
Autor:
Yael Aylon, Noa Furth, Giuseppe Mallel, Gilgi Friedlander, Nishanth Belugali Nataraj, Meng Dong, Ori Hassin, Rawan Zoabi, Benjamin Cohen, Vanessa Drendel, Tomer Meir Salame, Saptaparna Mukherjee, Nofar Harpaz, Randy Johnson, Walter E. Aulitzky, Yosef Yarden, Efrat Shema, Moshe Oren
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/d860069f12304f2f8bdcacb82805f013