Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Tomek Swigut"'
Autor:
Jaaved Mohammed, Neha Arora, Harold S Matthews, Karissa Hansen, Maram Bader, Susan Walsh, John R Shaffer, Seth M Weinberg, Tomek Swigut, Peter Claes, Licia Selleri, Joanna Wysocka
Publikováno v:
eLife, Vol 13 (2024)
Genome-wide association studies (GWAS) identified thousands of genetic variants linked to phenotypic traits and disease risk. However, mechanistic understanding of how GWAS variants influence complex morphological traits and can, in certain cases, si
Externí odkaz:
https://doaj.org/article/2cc1a2d4cf454d649f23f3d5f8c28b50
Autor:
Chenxing Liu, Myoung Keun Lee, Sahin Naqvi, Hanne Hoskens, Dongjing Liu, Julie D White, Karlijne Indencleef, Harold Matthews, Ryan J Eller, Jiarui Li, Jaaved Mohammed, Tomek Swigut, Stephen Richmond, Mange Manyama, Benedikt Hallgrímsson, Richard A Spritz, Eleanor Feingold, Mary L Marazita, Joanna Wysocka, Susan Walsh, Mark D Shriver, Peter Claes, Seth M Weinberg, John R Shaffer
Publikováno v:
PLoS Genetics, Vol 17, Iss 8, p e1009695 (2021)
Facial morphology is highly variable, both within and among human populations, and a sizable portion of this variation is attributable to genetics. Previous genome scans have revealed more than 100 genetic loci associated with different aspects of no
Externí odkaz:
https://doaj.org/article/dfb0218885724fd78f8a05fb3bc0ef13
Autor:
Paola A. Betancur, Brian J. Abraham, Ying Y. Yiu, Stephen B. Willingham, Farnaz Khameneh, Mark Zarnegar, Angera H. Kuo, Kelly McKenna, Yoko Kojima, Nicholas J. Leeper, Po Ho, Phung Gip, Tomek Swigut, Richard I. Sherwood, Michael F. Clarke, George Somlo, Richard A. Young, Irving L. Weissman
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Super-enhancers (SEs) are big DNA regions regulating the transcription of oncogenes. Here the authors identify two SE regions regulating the expression of CD47, a protein expressed by cancer cells to avoid phagocytosis by macrophages, thus suggesting
Externí odkaz:
https://doaj.org/article/78521d1c01db4a828a254b9785273b10
Publikováno v:
eLife, Vol 7 (2018)
Recent work suggests extensive adaptation of transposable elements (TEs) for host gene regulation. However, high numbers of integrations typical of TEs, coupled with sequence divergence within families, have made systematic interrogation of the regul
Externí odkaz:
https://doaj.org/article/d648205c14d44df0aa5fb148577f6183
Autor:
Caroline Townsend Stork, Michael Bocek, Madzia P Crossley, Julie Sollier, Lionel A Sanz, Frédéric Chédin, Tomek Swigut, Karlene A Cimprich
Publikováno v:
eLife, Vol 5 (2016)
The hormone estrogen (E2) binds the estrogen receptor to promote transcription of E2-responsive genes in the breast and other tissues. E2 also has links to genomic instability, and elevated E2 levels are tied to breast cancer. Here, we show that E2 s
Externí odkaz:
https://doaj.org/article/2a1e17c1ffb44c1cb044d013ec1a87a2
Autor:
Nataliya Nady, Ankit Gupta, Ziyang Ma, Tomek Swigut, Akiko Koide, Shohei Koide, Joanna Wysocka
Publikováno v:
eLife, Vol 4 (2015)
Prdm14 is a sequence-specific transcriptional regulator of embryonic stem cell (ESC) pluripotency and primordial germ cell (PGC) formation. It exerts its function, at least in part, through repressing genes associated with epigenetic modification and
Externí odkaz:
https://doaj.org/article/15fc5c9520f54014bc37bfa18b1db480
Publikováno v:
eLife, Vol 4 (2015)
Eukaryotic cells possess a variety of signaling pathways that prevent accumulation of unfolded and misfolded proteins. Chief among these is the heat shock response (HSR), which is assumed to respond to unfolded proteins in the cytosol and nucleus ali
Externí odkaz:
https://doaj.org/article/bfa68f54236f46f0bd1d48346a5f4432
Publikováno v:
PLoS Biology, Vol 2, Iss 1, p E6 (2004)
The infectious cycle of primate lentiviruses is intimately linked to interactions between cells of the immune system. Nef, a potent virulence factor, alters cellular environments to increase lentiviral replication in the host, yet the mechanisms unde
Externí odkaz:
https://doaj.org/article/c37b25e2ab22466f91117f891386fc89
Autor:
Sahin Naqvi, Seungsoo Kim, Hanne Hoskens, Harold S. Matthews, Richard A. Spritz, Ophir D. Klein, Benedikt Hallgrímsson, Tomek Swigut, Peter Claes, Jonathan K. Pritchard, Joanna Wysocka
Publikováno v:
Nature genetics, vol 55, iss 5
Transcriptional regulation exhibits extensive robustness, but human genetics indicates sensitivity to transcription factor (TF) dosage. Reconciling such observations requires quantitative studies of TF dosage effects at trait-relevant ranges, largely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e8456c8d532d9df5a007bfc6c19b55f
https://lirias.kuleuven.be/handle/20.500.12942/720126
https://lirias.kuleuven.be/handle/20.500.12942/720126
Autor:
Liang-Fu Chen, Hannah Katherine Long, Minhee Park, Tomek Swigut, Alistair Nicol Boettiger, Joanna Wysocka
Publikováno v:
Chen, L-F, Long, H K, Park, M, Swigut, T, Boettiger, A N & Wysocka, J 2023, ' Structural elements promote architectural stripe formation and facilitate ultra-long-range gene regulation at a human disease locus ', Molecular Cell . https://doi.org/10.1016/j.molcel.2023.03.009
Enhancer clusters overlapping disease-associated mutations in Pierre Robin sequence (PRS) patients regulate SOX9 expression at genomic distances over 1.25 Mb. We applied optical reconstruction of chromatin architecture (ORCA) imaging to trace 3D locu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b070cfb8cb5ad26193095e3f7462604c
https://hdl.handle.net/20.500.11820/90524519-a96c-4cf8-ba1d-79cf815b35a4
https://hdl.handle.net/20.500.11820/90524519-a96c-4cf8-ba1d-79cf815b35a4