Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Tomaszewski Miroslaw"'
Autor:
Wei Zhongyong, Johan Broddefalk, Madeleine Antonsson, Kosrat Amin, Jörgen Jensen, Johan Ulander, Maxime Tremblay, Stephane St-Onge, Karolina Nilsson, Shujuan Jin, Anders Lehmann, Alleyn T. Plowright, Christopher Walpole, Tomaszewski Miroslaw, Hua Yang
Publikováno v:
Journal of Medicinal Chemistry. 56:220-240
Agonists of the cannabinoid receptor 1 (CB1) have been suggested as possible treatments for a range of medical disorders including gastroesophageal reflux disease (GERD). While centrally acting cannabinoid agonists are known to produce psychotropic e
Autor:
Vijayaratnam Santhakumar, Tomaszewski Miroslaw, Shujuan Jin, Sandra I. Baltatu, Olivier St-Jean
Publikováno v:
Tetrahedron Letters. 53:1278-1281
Several 3-substituted pyrido[1,2,5]triazepin-4-ones and their benzo counterparts have been prepared in three steps from commercial starting materials. The key step involves S N Ar-type intramolecular nucleophilic aromatic substitution of the appropri
Autor:
Xuehong Luo, Xiao Hong Yu, Pourashraf Mehrnaz, Sanjay Srivastava, Dominic Salois, Cheng Yun-Xing, Kemal Payza, Christopher Walpole, Etienne Lessard, Stephane St-Onge, Tomaszewski Miroslaw
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:1619-1624
An oral, peripherally restricted CB1/CB2 agonist could provide an interesting approach to treat chronic pain by harnessing the analgesic properties of cannabinoids but without the well-known central side effects. γ-Carbolines are a novel class of po
Publikováno v:
Organic Letters. 12:3574-3577
A practical and highly efficient route to the synthesis of pharmaceutically interesting quinoxalinone scaffolds is reported. The key step involves an intramolecular palladium-catalyzed N-arylation under microwave irradiation. The developed methodolog
Publikováno v:
Synthetic Communications. 39:2614-2624
3-Phenyl propylthiol esters were investigated as “activatable” solution phase linkers. These linkers can be activated with silver salts and upon treatment with amines can be converted to the corresponding amides. Under unactivated conditions, the
Publikováno v:
Tetrahedron Letters. 49:3172-3175
A one-pot synthesis of the 2,3-dihydro-1 H -pyrrolo[3,2- c ]quinoline core from substituted 2-iodoanilines and 2,3-dihydro-1 H -pyrrole was achieved using 10 mol % Pd(PPh 3 ) 4 , and K 2 CO 3 in 1,4-dioxane at 170 °C for 1 h in a microwave oven. Thi
Publikováno v:
Tetrahedron Letters. 50:1435-1437
3-Aryl substituted benzo[1,2,5]triazepin-4-ones and their pyrido counterparts have been synthesized in five steps from commercially available starting materials. The key step involves base-induced cleavage of trifluoroacetyl-protected hydrazine inter
Publikováno v:
Tetrahedron Letters. 48:4925-4927
Silica-bound thiocarbamates were prepared by Curtius rearrangement of carboxylic acids in the presence of thiol on silica gel. The solid supported thiocarbamates were found to be stable isocyanate equivalents, which upon treatment with amines efficie
Autor:
Wei, Zhongyong, Yang, Hua, Liu, Ziping, Tremblay, Maxime, Johnstone, Shawn, Béha, Sara, Yue, Shi Yi, Srivastava, Sanjay, Tomaszewski, Miroslaw J., Brown, William, Walpole, Christopher, St-Onge, Stéphane, Lessard, Etienne, Archambault, Anne-Julie, Groblewski, Thierry, Pagé, Daniel
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 15 June 2012 22(12):3884-3889
Autor:
Cantin, Louis-David, Bayrakdarian, Malken, Buon, Christophe, Grazzini, Eric, Hu, Yun-Jin, Labrecque, Jean, Leung, Carmen, Luo, Xuehong, Martino, Giovanni, Paré, Michel, Payza, Kemal, Popovic, Nirvana, Projean, Denis, Santhakumar, V., Walpole, Christopher, Yu, Xiao Hong, Tomaszewski, Mirosław J.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1 April 2012 22(7):2565-2571