Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Tomasz Zok"'
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 6, p e1011959 (2024)
Unlike proteins, RNAs deposited in the Protein Data Bank do not contain topological knots. Recently, admittedly, the first trefoil knot and some lasso-type conformations have been found in experimental RNA structures, but these are still exceptional
Externí odkaz:
https://doaj.org/article/cb68e53914cf4cf5a231d36d5e1e50f3
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-7 (2020)
Abstract Background Quadruplexes are specific structure motifs occurring, e.g., in telomeres and transcriptional regulatory regions. Recent discoveries confirmed their importance in biomedicine and led to an intensified examination of their propertie
Externí odkaz:
https://doaj.org/article/19b8a4f2c2c844c4ba1510bd7956c468
Autor:
Julita Gumna, Maciej Antczak, Ryszard W. Adamiak, Janusz M. Bujnicki, Shi-Jie Chen, Feng Ding, Pritha Ghosh, Jun Li, Sunandan Mukherjee, Chandran Nithin, Katarzyna Pachulska-Wieczorek, Almudena Ponce-Salvatierra, Mariusz Popenda, Joanna Sarzynska, Tomasz Wirecki, Dong Zhang, Sicheng Zhang, Tomasz Zok, Eric Westhof, Zhichao Miao, Marta Szachniuk, Agnieszka Rybarczyk
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 9630 (2022)
RNA is a unique biomolecule that is involved in a variety of fundamental biological functions, all of which depend solely on its structure and dynamics. Since the experimental determination of crystal RNA structures is laborious, computational 3D str
Externí odkaz:
https://doaj.org/article/048d60b80d7a4bcf983e8249a3c929ea
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0239287 (2020)
RNAs adopt specific structures to perform their functions, which are critical to fundamental cellular processes. For decades, these structures have been determined and modeled with strong support from computational methods. Still, the accuracy of the
Externí odkaz:
https://doaj.org/article/23998fe8fa9d455fb83dc9363d4d370f
Autor:
Maciej Antczak, Tomasz Zok, Maciej Osowiecki, Mariusz Popenda, Ryszard W. Adamiak, Marta Szachniuk
Publikováno v:
BMC Bioinformatics, Vol 19, Iss 1, Pp 1-11 (2018)
Abstract Background Computational RNA 3D structure prediction and modeling are rising as complementary approaches to high-resolution experimental techniques for structure determination. They often apply to substitute or complement them. Recently, res
Externí odkaz:
https://doaj.org/article/7477060bad8d4e9681d2bb08e0a453dc
Publikováno v:
BMC Bioinformatics, Vol 18, Iss 1, Pp 1-13 (2017)
Abstract Background In modern structural bioinformatics, comparison of molecular structures aimed to identify and assess similarities and differences between them is one of the most commonly performed procedures. It gives the basis for evaluation of
Externí odkaz:
https://doaj.org/article/1ac01ad1ea87473ab8c15152856284ad
Publikováno v:
Nucleic Acids Research.
Quadruplexes are four-stranded DNA/RNA motifs of high functional significance that fold into complex shapes. They are widely recognized as important regulators of genomic processes and are among the most frequently investigated potential drug targets
Autor:
Kamil Luwanski, Vladyslav Hlushchenko, Mariusz Popenda, Tomasz Zok, Joanna Sarzynska, Daniil Martsich, Marta Szachniuk, Maciej Antczak
Publikováno v:
Nucleic Acids Research. 50:W663-W669
Advances in experimental and computational techniques enable the exploration of large and complex RNA 3D structures. These, in turn, reveal previously unstudied properties and motifs not characteristic for small molecules with simple architectures. E
Autor:
Joanna Sarzynska, Ryszard W. Adamiak, Agnieszka Korpeta, Marta Szachniuk, Mariusz Popenda, Tomasz Zok, Maciej Antczak
Publikováno v:
Nucleic Acids Research
Computational methods to predict RNA 3D structure have more and more practical applications in molecular biology and medicine. Therefore, it is crucial to intensify efforts to improve the accuracy and quality of predicted three-dimensional structures
Autor:
Jakub Wiedemann, Jacek Kaczor, Maciej Milostan, Tomasz Zok, Jacek Blazewicz, Marta Szachniuk, Maciej Antczak
Publikováno v:
Bioinformatics (Oxford, England). 38(17)
Motivation Knowledge of the 3D structure of RNA supports discovering its functions and is crucial for designing drugs and modern therapeutic solutions. Thus, much attention is devoted to experimental determination and computational prediction targeti