Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Tomasz Wojdyla"'
Autor:
Tomasz Wojdyla, Hrishikesh Mehta, Taly Glaubach, Roberto Bertolusso, Marta Iwanaszko, Rosemary Braun, Seth J Corey, Marek Kimmel
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 1, p e1006664 (2019)
Cancer development is driven by series of events involving mutations, which may become fixed in a tumor via genetic drift and selection. This process usually includes a limited number of driver (advantageous) mutations and a greater number of passeng
Externí odkaz:
https://doaj.org/article/3c9e276c10df4a57939f0b3857dddb2e
Autor:
Hrishikesh M Mehta, Marta Iwanaszko, Marek Kimmel, Rosemary Braun, Seth J. Corey, Tomasz Wojdyla, Roberto Bertolusso, Taly Glaubach
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 1, p e1006664 (2019)
PLoS Computational Biology
PLoS Computational Biology
Cancer development is driven by series of events involving mutations, which may become fixed in a tumor via genetic drift and selection. This process usually includes a limited number of driver (advantageous) mutations and a greater number of passeng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::457ed98134dbf86d8edc5b17e841f73f
https://doaj.org/article/3c9e276c10df4a57939f0b3857dddb2e
https://doaj.org/article/3c9e276c10df4a57939f0b3857dddb2e
Autor:
Seth J. Corey, Marek Kimmel, Tomasz Wojdyla, Taly Glaubach, Hrishikesh M. Mehta, Thomas O. McDonald
Publikováno v:
Cancer Research. 75:B2-50
We are developing new models to understand the evolution of Myelodysplastic Syndromes (MDS), a group of pre-leukemic blood diseases, which are increasing in incidence as the population is aging and which remain difficult to treat. In the early stage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::565cf82bd066b51f0d990c27ce357885
https://doi.org/10.1158/1538-7445.compsysbio-b2-50
https://doi.org/10.1158/1538-7445.compsysbio-b2-50
Publikováno v:
IFAC Proceedings Volumes. 47:11542-11546
We hypothesize that the GCSFR mutants introduce into those pathways changes that will lead to impaired differentiation and enhanced survival based on single cell behaviors as modulated by noise in intracellular proximal signaling and distal gene regu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3e6134eb0849b41fe6f9c895e65f1c4
https://doi.org/10.3182/20140824-6-za-1003.02095
https://doi.org/10.3182/20140824-6-za-1003.02095
Publikováno v:
Journal of Mathematical Biology. 61:455-473
In this paper, we extend the theoretical treatment of the Moran model of genetic drift with recombination and mutation, which was previously introduced by us for the case of two loci, to the case of n loci. Recombination, when considered in the Wrigh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dc050d7c2f3fb094d43efaa63cb00ce
https://doi.org/10.1007/s00285-009-0308-1
https://doi.org/10.1007/s00285-009-0308-1
Autor:
Tomasz Wojdyla, Marek Kimmel
Publikováno v:
AIP Conference Proceedings.
This contribution presents a brief study of conditions for fixation of a cancer driver mutation if selective pressures change during individual’s lifetime. A branching process model is used to represent the pre-selection stage, which leads to creat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69bd6815c42db93747cefb3c6cf54a01
https://doi.org/10.1063/1.4952111
https://doi.org/10.1063/1.4952111
Autor:
Tomasz Wojdyla, Marek Kimmel
Publikováno v:
Theoretical population biology. 111
Recent improvement in the quality of genetic data obtained from extinct human populations and their ancestors encourages searching for answers to basic questions regarding human population history. The most common and successful are model-based appro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf8d1aacfa14f516cfc5729c1a449181
https://pubmed.ncbi.nlm.nih.gov/27378746
https://pubmed.ncbi.nlm.nih.gov/27378746
Publikováno v:
Theoretical population biology. 80(4)
Determining the expected distribution of the time to the most recent common ancestor of a sample of individuals may deliver important information about the genetic markers and evolution of the population. In this paper, we introduce a new recursive a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dca236e10b6fb76af45aabac8de63df
https://pubmed.ncbi.nlm.nih.gov/22008854
https://pubmed.ncbi.nlm.nih.gov/22008854