Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Tomasz Wichur"'
Autor:
Izabella Góral, Tomasz Wichur, Emilia Sługocka, Justyna Godyń, Natalia Szałaj, Paula Zaręba, Monika Głuch-Lutwin, Barbara Mordyl, Dawid Panek, Anna Więckowska
Publikováno v:
Molecules, Vol 29, Iss 11, p 2616 (2024)
GSK-3β, IKK-β, and ROCK-1 kinases are implicated in the pathomechanism of Alzheimer’s disease due to their involvement in the misfolding and accumulation of amyloid β (Aβ) and tau proteins, as well as inflammatory processes. Among these kinases
Externí odkaz:
https://doaj.org/article/d794b4a155cb4c9da646e809bc8a5781
Autor:
Natalia Szałaj, Justyna Godyń, Jakub Jończyk, Anna Pasieka, Dawid Panek, Tomasz Wichur, Krzysztof Więckowski, Paula Zaręba, Marek Bajda, Anja Pislar, Barbara Malawska, Raimon Sabate, Anna Więckowska
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1944-1952 (2020)
Effective therapy of Alzheimer’s disease (AD) requires treatment with a combination of drugs that modulate various pathomechanisms contributing to the disease. In our research, we have focused on the development of multi-target-directed ligands –
Externí odkaz:
https://doaj.org/article/8664353705ab4c3dbfa4416d81bfa9d5
Autor:
Krzysztof Więckowski, Natalia Szałaj, Beata Gryzło, Tomasz Wichur, Izabella Góral, Emilia Sługocka, Joanna Sniecikowska, Gniewomir Latacz, Agata Siwek, Justyna Godyń, Adam Bucki, Marcin Kołaczkowski, Anna Więckowska
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 16, p 9443 (2022)
Neurodegeneration leading to Alzheimer’s disease results from a complex interplay of a variety of processes including misfolding and aggregation of amyloid beta and tau proteins, neuroinflammation or oxidative stress. Therefore, to address more tha
Externí odkaz:
https://doaj.org/article/5e6a4adb70654c7fbae2ddbb60204c61
Autor:
Michalina Hebda, Marek Bajda, Anna Więckowska, Natalia Szałaj, Anna Pasieka, Dawid Panek, Justyna Godyń, Tomasz Wichur, Damijan Knez, Stanislav Gobec, Barbara Malawska
Publikováno v:
Molecules, Vol 21, Iss 4, p 410 (2016)
Cholinesterases and amyloid beta are one of the major biological targets in the search for a new and efficacious treatment of Alzheimer’s disease. The study describes synthesis and pharmacological evaluation of new compounds designed as dual bindin
Externí odkaz:
https://doaj.org/article/6783527ad45f4c018b3bc70940f4a966
Autor:
Krzysztof, Więckowski, Natalia, Szałaj, Beata, Gryzło, Tomasz, Wichur, Izabella, Góral, Emilia, Sługocka, Joanna, Sniecikowska, Gniewomir, Latacz, Agata, Siwek, Justyna, Godyń, Adam, Bucki, Marcin, Kołaczkowski, Anna, Więckowska
Publikováno v:
International journal of molecular sciences. 23(16)
Neurodegeneration leading to Alzheimer's disease results from a complex interplay of a variety of processes including misfolding and aggregation of amyloid beta and tau proteins, neuroinflammation or oxidative stress. Therefore, to address more than
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6bd4358802443ef327e1978a76a7da5a
https://pubmed.ncbi.nlm.nih.gov/36012707
https://pubmed.ncbi.nlm.nih.gov/36012707
Autor:
Anja Pišlar, Anna Więckowska, Barbara Malawska, Paula Zaręba, Raimon Sabaté, Dawid Panek, Jakub Jończyk, Tomasz Wichur, Natalia Szałaj, Anna Pasieka, Krzysztof Więckowski, Justyna Godyń, Marek Bajda
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1944-1952 (2020)
Effective therapy of Alzheimer’s disease (AD) requires treatment with a combination of drugs that modulate various pathomechanisms contributing to the disease. In our research, we have focused on the development of multi-target-directed ligands –
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::605fad8a83670327e0c22e4f705ac0bf
https://doi.org/10.1080/14756366.2020.1835882
https://doi.org/10.1080/14756366.2020.1835882
Autor:
Tomasz, Wichur, Anna, Pasieka, Justyna, Godyń, Dawid, Panek, Izabella, Góral, Gniewomir, Latacz, Ewelina, Honkisz-Orzechowska, Adam, Bucki, Agata, Siwek, Monika, Głuch-Lutwin, Damijan, Knez, Xavier, Brazzolotto, Stanislav, Gobec, Marcin, Kołaczkowski, Raimon, Sabate, Barbara, Malawska, Anna, Więckowska
Publikováno v:
European journal of medicinal chemistry. 225
Multifunctional ligands as an essential variant of polypharmacology are promising candidates for the treatment of multi-factorial diseases like Alzheimer's disease. Based on clinical evidence and following the paradigm of multifunctional ligands we h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::077914f6dc7def7c5c689536d69bdbf6
https://pubmed.ncbi.nlm.nih.gov/34461507
https://pubmed.ncbi.nlm.nih.gov/34461507
Autor:
Tomasz, Wichur, Justyna, Godyń, Izabella, Góral, Gniewomir, Latacz, Adam, Bucki, Agata, Siwek, Monika, Głuch-Lutwin, Barbara, Mordyl, Joanna, Śniecikowska, Maria, Walczak, Damijan, Knez, Marko, Jukič, Kinga, Sałat, Stanislav, Gobec, Marcin, Kołaczkowski, Barbara, Malawska, Xavier, Brazzolotto, Anna, Więckowska
Publikováno v:
European journal of medicinal chemistry. 225
The lack of an effective treatment makes Alzheimer's disease a serious healthcare problem and a challenge for medicinal chemists. Herein we report interdisciplinary research on novel multifunctional ligands targeting proteins and processes involved i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ee45fc25145a25e10b16d6f82c3ab957
https://pubmed.ncbi.nlm.nih.gov/34530376
https://pubmed.ncbi.nlm.nih.gov/34530376
Autor:
Natalia, Szałaj, Justyna, Godyń, Jakub, Jończyk, Anna, Pasieka, Dawid, Panek, Tomasz, Wichur, Krzysztof, Więckowski, Paula, Zaręba, Marek, Bajda, Anja, Pislar, Barbara, Malawska, Raimon, Sabate, Anna, Więckowska
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Effective therapy of Alzheimer’s disease (AD) requires treatment with a combination of drugs that modulate various pathomechanisms contributing to the disease. In our research, we have focused on the development of multi-target-directed ligands –
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::42a15e91c6c4c4598f6f76b83b7e9d77
https://pubmed.ncbi.nlm.nih.gov/33092411
https://pubmed.ncbi.nlm.nih.gov/33092411
Autor:
Xavier Brazzolotto, Izabella Góral, Anna Pasieka, Gniewomir Latacz, Anna Więckowska, Adam Bucki, Dawid Panek, Barbara Malawska, Marcin Kołaczkowski, Tomasz Wichur, Raimon Sabaté, Damijan Knez, Monika Głuch-Lutwin, Justyna Godyń, Ewelina Honkisz-Orzechowska, Stanislav Gobec, Agata Siwek
Publikováno v:
European Journal of Medicinal Chemistry. 225:113783
Multifunctional ligands as an essential variant of polypharmacology are promising candidates for the treatment of multi-factorial diseases like Alzheimer's disease. Based on clinical evidence and following the paradigm of multifunctional ligands we h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e6511bad0aaf428df90277374a636a
https://doi.org/10.1016/j.ejmech.2021.113783
https://doi.org/10.1016/j.ejmech.2021.113783