Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Tomasz Sosinowski"'
The discovery of a reciprocal relationship between tyrosine-kinase signaling and cullin neddylation.
Autor:
Samantha F Friend, Lisa K Peterson, Eric Treacy, Adrianne L Stefanski, Tomasz Sosinowski, Nathan D Pennock, Allison J Berger, Virginia D Winn, Leonard L Dragone
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e75200 (2013)
While neddylation is known to activate cullin (CUL)-RING ubiquitin ligases (CRLs), its role in regulating T cell signaling is poorly understood. Using the investigational NEDD8 activating enzyme (NAE) inhibitor, MLN4924, we found that neddylation neg
Externí odkaz:
https://doaj.org/article/a9831c2e8e4c40d781ac6f9850536470
Autor:
Philippa Marrack, Shaodong Dai, John W. Kappler, William W. Kwok, Yang Wang, Frances Crawford, David B. Neau, Andrey Novikov, Junbao Yang, Tomasz Sosinowski
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Insulin is a target of CD4 T cells in type 1 diabetes in mice and humans. Why the major epitope in the insulin B chain is presented poorly to the diabetogenic CD4 T cells by the disease-associated major histocompatibility class II (MHCII
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99d864b1bb7d4c778c8b5419c7b7e050
https://doi.org/10.1073/pnas.1716527115
https://doi.org/10.1073/pnas.1716527115
Autor:
Joseph Ray Cepeda, Ling Gao, Junying Han, Nitin S Sekhar, Howard W. Davidson, Tomasz Sosinowski, Li Zhang
Publikováno v:
Journal of Visualized Experiments.
Type 1 Diabetes (T1D) is characterized by islet-specific autoimmunity leading to beta cell destruction and absolute loss of insulin production. In the spontaneous non-obese diabetes (NOD) mouse model, insulin is the primary target, and genetic manipu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6288ef3debfc0759e956cdb41dd6a84a
https://doi.org/10.3791/59985-v
https://doi.org/10.3791/59985-v
Autor:
Joseph Ray Cepeda, Tomasz Sosinowski, Liping Yu, Li Zhang, Howard W. Davidson, Sean M. Hartig, Dongmei Miao, Nitin S Sekhar, Aaron R. Cox, Massimo Pietropaolo
A primary initiating epitope in the NOD mouse model of Type 1 Diabetes (T1D) lies between residues 9 and 23 of the insulin B chain. The B:9–23 peptide can bind to the NOD MHC class II molecule (I-A(g7)) in multiple registers, but only one, (registe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be8e4480f3f4fa81847b8bb7c228ab8
https://europepmc.org/articles/PMC6541442/
https://europepmc.org/articles/PMC6541442/
Autor:
Dario A. A. Vignali, Kathryn Haskins, Laurent Gapin, Tomasz Sosinowski, Todd A. Castoe, Maki Nakayama, XiangLing He, George S. Eisenbarth, David D. Pollock, Kelly Johnson
Publikováno v:
Diabetes
There is accumulating evidence that autoimmunity to insulin B chain peptide, amino acids 9–23 (insulin B:9–23), is central to development of autoimmune diabetes of the NOD mouse model. We hypothesized that enhanced susceptibility to autoimmune di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3706a638a3921b9199c48b41685a53cd
https://doi.org/10.2337/db11-1113
https://doi.org/10.2337/db11-1113
Autor:
Margaret D. Myers, Carmen White, Arthur Weiss, Hamid Band, Leonard L. Dragone, Tomasz Sosinowski, Hua Gu
Publikováno v:
Nature Immunology. 7:57-66
The adaptor molecule SLAP and E3 ubiquitin ligase c-Cbl each regulate expression of T cell receptor (TCR)-CD3 on thymocytes. Here we provide genetic and biochemical evidence that both molecules function in the same pathway. TCR-CD3 expression was sim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca3ca5db8213fdff648b164194843cd2
https://doi.org/10.1038/ni1291
https://doi.org/10.1038/ni1291
Autor:
William W. Kwok, Carla J. Greenbaum, Tomasz Sosinowski, Nadia Torres-Chinn, I-Ting Chow, Howard W. Davidson, John W. Kappler, Junbao Yang, Eddie A. James
Previous studies in type 1 diabetes (T1D) in the nonobese diabetic mouse demonstrated that a crucial insulin epitope (B:9-23) is presented to diabetogenic CD4 T cells by IA(g7) in a weakly bound register. The importance of antigenic peptides with low
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b26a9e862c3246c97fa00defec29850
https://europepmc.org/articles/PMC4205657/
https://europepmc.org/articles/PMC4205657/
Autor:
Yun Chien, Tsung-Lin Lee, Li-Fang Wang, Jau-Shiuh Chen, Chia-Chi Ku, Mei-Ling Chang, Yi-Hsuan Chang, John T. Kung, Ming-Hsun Tsai, Yi-Yuan Chen, Che-Ming Chuang, Chih-Hsiu Wang, Tomasz Sosinowski, Chien-Kuo Lee, Yu-Jei Lin
Publikováno v:
The Journal of investigative dermatology. 135(5)
In a routine phenotype-driven screen, we identified a point mutation in exon 7 of the IL-15 gene in Pedigree 191 (deficient memory (DM)) of N-ethyl-N-nitrosourea mutagenized mice. The DM epidermis expressed an alternatively spliced IL-15 mRNA isoform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5262a9d1fc35510d8f5bd8d2e69e25b5
https://pubmed.ncbi.nlm.nih.gov/25615554
https://pubmed.ncbi.nlm.nih.gov/25615554
Publikováno v:
Immunity. 15:457-466
In this report, we show that the Src-like adaptor protein (SLAP) plays an important role in thymocyte development. SLAP expression is developmentally regulated; it is low in CD4 − CD8 − thymocytes, it peaks in the CD4 + CD8 + subset, and it decre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8b1d67303097bb8c6594cf6c55d9aab
https://doi.org/10.1016/s1074-7613(01)00195-9
https://doi.org/10.1016/s1074-7613(01)00195-9
Autor:
Irina Kratchmarova, Klaus Witter, Tomasz Sosinowski, Claudius Vincenz, Arthur Weiss, Akhilesh Pandey
Publikováno v:
Gene. 262:267-273
Src-like adapter protein (SLAP) was identified as a signaling molecule in a yeast two-hybrid system using the cytoplasmic domain of EphA2, a receptor protein tyrosine kinase ( Pandey et al., 1995a , Pandey et al., 1995b . Characterization of a novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca9ac6081b5a0bd865de3ab52025725d
https://doi.org/10.1016/s0378-1119(00)00516-3
https://doi.org/10.1016/s0378-1119(00)00516-3