IGF2 Peptide-Based LYTACs for Targeted Degradation of Extracellular and Transmembrane Proteins

Autor: Michał Mikitiuk, Jan Barczyński, Przemysław Bielski, Marcelino Arciniega, Urszula Tyrcha, Aleksandra Hec, Andrea D. Lipińska, Michał Rychłowski, Tad A. Holak, Tomasz Sitar

Publikováno v: Molecules, Vol 28, Iss 22, p 7519 (2023)

Lysosome-targeting chimeras (LYTACs) have recently been developed to facilitate the lysosomal degradation of specific extracellular and transmembrane molecular targets. However, the LYTAC particles described to date are based on glycopeptide conjugat

Externí odkaz: https://doaj.org/article/3953071d4d124e7382acdaaa72b81cb4

Structures of actin-bound Wiskott-Aldrich syndrome protein homology 2 (WH2) domains of Spire and the implication for filament nucleation

Autor: Kathleen M. Trybus, Tad A. Holak, Grzegorz M. Popowicz, Peteranne B. Joel, Anna M. Ducka, Angelika A. Noegel, Michael Schleicher, Robert Huber, Tomasz Sitar

Publikováno v: Proceedings of the National Academy of Sciences. 107:11757-11762

Three classes of proteins are known to nucleate new filaments: the Arp2/3 complex, formins, and the third group of proteins that contain ca. 25 amino acid long actin-binding Wiskott-Aldrich syndrome protein homology 2 domains, called the WH2 repeats.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61a0e4138f3fa3d69d0948e8d5969f4f
https://doi.org/10.1073/pnas.1005347107

Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins

Autor: Tomasz Sitar, Robert Huber, Igor Siwanowicz, Tad A. Holak, Grzegorz M. Popowicz

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 103(35)

Insulin-like growth factor-binding proteins (IGFBPs) control bioavailability, activity, and distribution of insulin-like growth factor (IGF)1 and -2 through high-affinity IGFBP/IGF complexes. IGF-binding sites are found on N- and C-terminal fragments

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ec52b78dfada01b381ba03ddbf06a61
https://pubmed.ncbi.nlm.nih.gov/16924115

Correction.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America; 10/25/2016, Vol. 113 Issue 43, pE6721-E6721, 1p

N-methylmorpholine incorporation into the structure of biphenyl leads to the bioactive inhibitor of PD-1/PD-L1 interaction.

Autor: Zaber J; Jagiellonian University, Doctoral School of Exact and Natural Sciences, prof. S. Lojasiewicza 11, 30-348 Krakow, Poland; Jagiellonian University, Faculty of Chemistry, Department of Organic Chemistry, Gronostajowa 2, 30-387 Krakow, Poland., Skalniak L; Jagiellonian University, Faculty of Chemistry, Department of Organic Chemistry, Gronostajowa 2, 30-387 Krakow, Poland., Gudz GP; Jagiellonian University, Faculty of Chemistry, Department of Organic Chemistry, Gronostajowa 2, 30-387 Krakow, Poland., Hec-Gałązka A; Jagiellonian University, Doctoral School of Exact and Natural Sciences, prof. S. Lojasiewicza 11, 30-348 Krakow, Poland; Jagiellonian University, Faculty of Chemistry, Department of Organic Chemistry, Gronostajowa 2, 30-387 Krakow, Poland; Recepton Sp. z o.o., ul. Trzy Lipy 3, 80-172 Gdansk, Poland., Zarnik M; Jagiellonian University, Faculty of Chemistry, Department of Organic Chemistry, Gronostajowa 2, 30-387 Krakow, Poland., Tyrcha U; Recepton Sp. z o.o., ul. Trzy Lipy 3, 80-172 Gdansk, Poland., Stec M; Department of Clinical Immunology, Institute of Pediatrics, Jagiellonian University Medical College, Wielicka 265, 30-663 Krakow, Poland., Siedlar M; Department of Clinical Immunology, Institute of Pediatrics, Jagiellonian University Medical College, Wielicka 265, 30-663 Krakow, Poland., Holak TA; Jagiellonian University, Faculty of Chemistry, Department of Organic Chemistry, Gronostajowa 2, 30-387 Krakow, Poland; Recepton Sp. z o.o., ul. Trzy Lipy 3, 80-172 Gdansk, Poland., Sitar T; Recepton Sp. z o.o., ul. Trzy Lipy 3, 80-172 Gdansk, Poland., Muszak D; Jagiellonian University, Faculty of Chemistry, Department of Organic Chemistry, Gronostajowa 2, 30-387 Krakow, Poland. Electronic address: damian.muszak@uj.edu.pl.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2024 Sep 15; Vol. 110, pp. 129882. Date of Electronic Publication: 2024 Jul 10.