Výsledky vyhledávání - "Tomasz Obrzut"

Selective Antimicrotubule Activity ofN1-Phenyl-3,5-dinitro-N4,N4-di-n-propylsulfanilamide (GB-II-5) against Kinetoplastid Parasites

Autor: Gautam Bhattacharya, Dan L. Sackett, Manar M. Salem, Dawn A. Delfín, Cyrus J. Bacchi, Donna Rattendi, Karl A. Werbovetz, Tomasz Obrzut

Publikováno v: Molecular Pharmacology. 64:1325-1333

Analogs of the antimitotic herbicide oryzalin (3,5-dinitro-N4,N4-di-n-propylsulfanilamide) were recently prepared that were more potent in vitro than the parent compound against the kinetoplastid parasite Leishmania donovani (Bioorg Med Chem Lett 12:

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70e320f3aeda24e20445c991030f3f45
https://doi.org/10.1124/mol.64.6.1325

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Becatecarin (rebeccamycin analog, NSC 655649) is a transport substrate and induces expression of the ATP-binding cassette transporter, ABCG2, in lung carcinoma cells

Autor: Robert W. Robey, Tomasz Obrzut, Orsolya Polgar, Suneet Shukla, Attilio Di Pietro, Suresh V. Ambudkar, Julian C. Bahr, Susan E. Bates, Sira Macalou

ABCG2 overexpression has been linked to resistance to topoisomerase inhibitors, leading us to examine the potential interaction between ABCG2 and becatecarin.Interaction with ABCG2 was determined by ATPase assay, competition of [(125)I]iodoarylazidop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfccdaffff31d6902544e4e8c197b7b5
https://europepmc.org/articles/PMC2693460/

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Inhibition of ABCG2-mediated transport by protein kinase inhibitors with a bisindolylmaleimide or indolocarbazole structure

Autor: Kenneth Steadman, Suneet Shukla, Susan E. Bates, Elizabeth M. Finley, Tomasz Obrzut, Robert W. Robey, Suresh V. Ambudkar

Publikováno v: Molecular cancer therapeutics. 6(6)

ABCG2 is a transporter with potential importance in cancer drug resistance, drug oral absorption, and stem cell biology. In an effort to identify novel inhibitors of ABCG2, we examined the ability of commercially available bisindolylmaleimides (BIM)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1d2e8d47d63358c15fa5aa8dd67edaa
https://pubmed.ncbi.nlm.nih.gov/17575116

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Periodical

Selective antimicrotubule activity of N1-phenyl-3,5-dinitro-N4,N4-di-n-propylsulfanilamide (GB-II-5) against kinetoplastid parasites.

Autor: A, Werbovetz Karl, L, Sackett Dan, Dawn, Delfn, Gautam, Bhattacharya, Manar, Salem, Tomasz, Obrzut, Donna, Rattendi, Cyrus, Bacchi

Publikováno v: Molecular Pharmacology; December 2003, Vol. 64 Issue: 6 p1325-33, 9p

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