Zobrazeno 1 - 10
of 244
pro vyhledávání: '"Tomasz Misztal"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Relatively low levels of antioxidant enzymes coupled with high oxygen metabolism result in the formation of numerous oxidative DNA damages in the tissues of the central nervous system. Recently, kynurenic acid (KYNA), knowns for its neuropro
Externí odkaz:
https://doaj.org/article/ae9cd96413e2455c9c72c28131c31a6f
Autor:
Tomasz Misztal, Katarzyna Roszkowicz-Ostrowska, Paweł Kowalczyk, Patrycja Młotkowska, Elżbieta Marciniak
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 17, p 9428 (2024)
Kynurenic acid (KYNA), a tryptophan metabolite, is believed to exert neuromodulatory and neuroprotective effects in the brain. This study aimed to examine KYNA’s capacity to modify gene expression and the activity of cellular antioxidant enzymes in
Externí odkaz:
https://doaj.org/article/2b8c76d66f5c4a82ade7e3d46cc2fb66
Publikováno v:
In Biomedicine & Pharmacotherapy 31 December 2023 169
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 4845 (2024)
In recent years, there has been a marked increase in interest in the role of the kynurenine pathway (KP) in mechanisms associated with addictive behavior. Numerous reports implicate KP metabolism in influencing the immune system, hypothalamic–pitui
Externí odkaz:
https://doaj.org/article/9f7ca90c1b0d4c28a2c59c79e77fe058
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 2997 (2024)
Adrenaline has recently been found to trigger phosphatidylserine (PS) exposure on blood platelets, resulting in amplification of the coagulation process, but the mechanism is only fragmentarily established. Using a panel of platelet receptors’ anta
Externí odkaz:
https://doaj.org/article/a4983cbf62cb4b288f16aa42d45e046f
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
The short form of the leptin receptor (LeptRa) plays a key role in the transport of leptin to the central nervous system (CNS). Here, MTS-leptin and recombinant ovine (ro) leptin-mediated expression of LeptRa and VEGFA and VEGFR2 concentration in sel
Externí odkaz:
https://doaj.org/article/93a90a319c1f4687b61ae5ff7ae06a82
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are antihyperglycemic drugs that decrease mortality from cardiovascular diseases. However, their effects on hemostasis in the cardioprotective effects have not been evaluated. Therefore, the
Externí odkaz:
https://doaj.org/article/97567da37d384bccabe479389696faac
Autor:
Natalia Bielicka, Adrian Stankiewicz, Tomasz Misztal, Szymon Kocańda, Ewa Chabielska, Anna Gromotowicz-Popławska
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 17, p 13254 (2023)
Platelet endothelial cell adhesion molecule 1 (PECAM-1) is considered an antiplatelet molecule. Previously, we introduced a new parameter called the PECAM-1/thrombus ratio, which indicates the proportion of PECAM-1 in the thrombus and provides a prec
Externí odkaz:
https://doaj.org/article/2ee1f5bfb6e24ec3bfc074e4f8c05844
Publikováno v:
Animals, Vol 13, Iss 10, p 1658 (2023)
Oxytocin (OT) is a neuropeptide synthesized in the hypothalamic nuclei that modulates both behavioral and reproductive functions, associated with the increased neurosteroid synthesis in the brain. Therefore, the present study tested the hypothesis th
Externí odkaz:
https://doaj.org/article/ab0770749cac4938b752aa84f7b49aef
Autor:
Katarzyna Roszkowicz-Ostrowska, Patrycja Młotkowska, Paweł Kowalczyk, Elżbieta Marciniak, Marcin Barszcz, Tomasz Misztal
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 136 (2022)
Deficiency of neurotrophic factors and oxidative DNA damage are common causes of many neurodegenerative diseases. Recently, the importance of kynurenic acid (KYNA), an active metabolite of tryptophan, has increased as a neuroprotective molecule in th
Externí odkaz:
https://doaj.org/article/56c404f2015541b0931844f359dacc3f