Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Tomasz Klaus"'
Autor:
Dawid Chomicz, Jarosław Kończak, Sonia Wróbel, Tadeusz Satława, Paweł Dudzic, Bartosz Janusz, Mateusz Tarkowski, Piotr Deszyński, Tomasz Gawłowski, Anna Kostyn, Marek Orłowski, Tomasz Klaus, Lukas Schulte, Kyle Martin, Stephen R. Comeau, Konrad Krawczyk
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Antibodies are proteins produced by our immune system that have been harnessed as biotherapeutics. The discovery of antibody-based therapeutics relies on analyzing large volumes of diverse sequences coming from phage display or animal immunizations.
Externí odkaz:
https://doaj.org/article/bea9fd2ccdc045aba644a4813da35455
Autor:
Tadeusz Satława, Mateusz Tarkowski, Sonia Wróbel, Paweł Dudzic, Tomasz Gawłowski, Tomasz Klaus, Marek Orłowski, Anna Kostyn, Sandeep Kumar, Andrew Buchanan, Konrad Krawczyk
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 3, p e1011881 (2024)
Antibody-based therapeutics must not undergo chemical modifications that would impair their efficacy or hinder their developability. A commonly used technique to de-risk lead biotherapeutic candidates annotates chemical liability motifs on their sequ
Externí odkaz:
https://doaj.org/article/cff3dcbea5874d0a8c29f6bd8aadeb8d
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract The binding of mouse IgG3 to Fcγ receptors (FcγR) and the existence of a mouse IgG3-specific receptor have been discussed for 40 years. Recently, integrin beta-1 (ITGB1) was proposed to be a part of an IgG3 receptor involved in the phagocy
Externí odkaz:
https://doaj.org/article/2bbaaea2d9a7418096ecc6dd6f69a07b
Autor:
Tomasz Klaus, Sameer Deshmukh
Publikováno v:
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-14 (2021)
Abstract Therapeutic antibodies are instrumental in improving the treatment outcome for certain disease conditions. However, to enhance their efficacy and specificity, many efforts are continuously made. One of the approaches that are increasingly ex
Externí odkaz:
https://doaj.org/article/a8f2bf41eccb4cbebf4e6ee2b081846d
Autor:
Tomasz Klaus, Joanna Bereta
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Mouse IgG3 is highly protective against several life-threatening bacteria. This isotype is the only one among mouse IgGs that forms non-covalent oligomers, has increased functional affinity to polyvalent antigens, and efficiently agglutinates erythro
Externí odkaz:
https://doaj.org/article/c74f37eb868a4526b6a926b7b17d288c
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
The binding of mouse IgG3 to Fcγ receptors (FcγR) and the existence of a mouse IgG3-specific receptor have been discussed for 40 years. Recently, integrin beta-1 (ITGB1) was proposed to be a part of an IgG3 receptor involved in the phagocytosis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d03a65be2030abced9e817dda325a80
https://pubmed.ncbi.nlm.nih.gov/33986441
https://pubmed.ncbi.nlm.nih.gov/33986441
Autor:
Joanna Bereta, Krystyna Stalińska, Sylwia Kedracka-Krok, Paweł Mak, Tomasz Klaus, Dominik Czaplicki, Karolina Wiatrowska, Bozena Skupien-Rabian, Monika Bzowska, Monika Machula
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
IgM is a multivalent antibody which evolved as a first line defense of adaptive immunity. It consists of heavy and light chains assembled into a complex oligomer. In mouse serum there are two forms of IgM, a full-length and a truncated one. The latte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1099f5d8dc639d5ee8af8029bd0cf765
https://doi.org/10.1038/s41598-017-19003-4
https://doi.org/10.1038/s41598-017-19003-4
Autor:
Tomasz Klaus, Jakub Golab, Katarzyna Tonecka, Louis Boon, Magdalena Gabrysiak, Zofia Pilch, Joanna Stachura, Angelika Muchowicz, Dominika Wolosz, Witold W. Kilarski, Malgorzata Wachowska
Publikováno v:
European Journal of Cancer
Photodynamic therapy (PDT) has been shown to destroy tumour-associated lymphatic vessels. Therefore, we sought to investigate the functional outcomes of PDT-mediated damage to the lymphatic vessels. We observed that PDT with verteporfin, completely b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da7e07d7b1a59111594bfebea4ef31e7
Autor:
Agnieszka Martyna Kabat, Monika Bzowska, Krzysztof Makuch, Małgorzata Jemioła-Rzemińska, Tomasz Klaus, Jarosław Jucha, Małgorzata Kulesza, Joanna Bereta, Alicja Karabasz, Dominik Czaplicki
Publikováno v:
Scientific Reports
Mouse immunoglobulins M (IgMs) that recognize human blood group antigens induce haemagglutination and are used worldwide for diagnostic blood typing. Contrary to the current belief that IgGs are too small to simultaneously bind antigens on two differ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b71f1fbf876c03b737cd53c43f60502b
http://europepmc.org/articles/PMC4971511
http://europepmc.org/articles/PMC4971511
Autor:
Karolina Ossysek, Monika Bzowska, Klaudia Woś, Małgorzata Kulesza, Mariusz Madej, Joanna Bereta, Tomasz Uchański, Tomasz Klaus
Tomlinson I+J are synthetic phagemid human scFv libraries widely employed to obtain specific antibody fragments via a phage display method. The pIT2/HB2151 expression system proposed by the designers of the libraries has certain drawbacks which resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1901067ffb99ee64e2e42727a63fb77f
http://ruj.uj.edu.pl/xmlui/handle/item/20710
http://ruj.uj.edu.pl/xmlui/handle/item/20710
