IRAK2 directs stimulus-dependent nuclear export of inflammatory mRNAs

Autor: Hao Zhou, Katarzyna Bulek, Xiao Li, Tomasz Herjan, Minjia Yu, Wen Qian, Han Wang, Gao Zhou, Xing Chen, Hui Yang, Lingzi Hong, Junjie Zhao, Luke Qin, Koichi Fukuda, Annette Flotho, Ji Gao, Ashok Dongre, Julie A Carman, Zizhen Kang, Bing Su, Timothy S Kern, Jonathan D Smith, Thomas A Hamilton, Frauke Melchior, Paul L Fox, Xiaoxia Li

Publikováno v: eLife, Vol 6 (2017)

Expression of inflammatory genes is determined in part by post-transcriptional regulation of mRNA metabolism but how stimulus- and transcript-dependent nuclear export influence is poorly understood. Here, we report a novel pathway in which LPS/TLR4 e

Externí odkaz: https://doaj.org/article/5b84f1b2b69f41da8fc9474e0ca9c10d

RNA-binding protein HuR promotes airway inflammation in a house dust mite-induced allergic asthma model

Autor: Tomasz Herjan, Jianxin Xiao, Monika Dziendziel Kolanek

Publikováno v: Journal of Interferon & Cytokine Research

Mounting evidence indicates that interleukin 17 (IL-17) is critically involved in the pathogenesis of severe asthma. We have previously reported that upon IL-17 stimulation, Act1, an IL-17-receptor-complex adaptor, directly binds to its target mRNAs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b206d5390281ac998b60831132465f48
https://ruj.uj.edu.pl/xmlui/handle/item/290789

Neuron-Specific HuR-Deficient Mice Spontaneously Develop Motor Neuron Disease

Autor: Xing Chen, Ying Bai, Tomasz Herjan, Ching-Yi Lin, Xiao Li, Olga N. Kokiko-Cochran, Yu Shang Lee, Kevin Sun, Gao Zhou, Bruce T. Lamb, Thomas A. Hamilton

Publikováno v: The Journal of Immunology. 201:157-166

Human Ag R (HuR) is an RNA binding protein in the ELAVL protein family. To study the neuron-specific function of HuR, we generated inducible, neuron-specific HuR-deficient mice of both sexes. After tamoxifen-induced deletion of HuR, these mice develo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09e9b2110581992269bcca99e30d63c0
https://doi.org/10.4049/jimmunol.1701501

IL-17A Recruits Rab35 to IL-17R to Mediate PKCα-Dependent Stress Fiber Formation and Airway Smooth Muscle Contractility

Autor: Dean Sheppard, Jarod A. Zepp, Tomasz Herjan, Xiaoxia Li, Stavros Garantziotis, Alana K. Majors, Katarzyna Bulek, Suidong Ouyang, Arnaud Echard, Julie Carman, Mark A. Aronica, Xing Chen, Malgorzata Bodaszewska-Lubas, Ashok Dongre, Aparna Sundaram, Vandy I. Parron, Ji Gao, Caini Liu

Publikováno v: Journal of immunology (Baltimore, Md. : 1950), vol 202, iss 5
Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2019, 202 (5), pp.1540-1548. ⟨10.4049/jimmunol.1801025⟩
Journal of Immunology, 2019, 202 (5), pp.1540-1548. ⟨10.4049/jimmunol.1801025⟩

IL-17A is a critical proinflammatory cytokine for the pathogenesis of asthma including neutrophilic pulmonary inflammation and airway hyperresponsiveness. In this study, by cell type–specific deletion of IL-17R and adaptor Act1, we demonstrated tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70315491f6a6a6377f8739dacdebded9
https://escholarship.org/uc/item/6hj7w802

Author response: IRAK2 directs stimulus-dependent nuclear export of inflammatory mRNAs

Autor: Timothy S. Kern, Katarzyna Bulek, Wen Qian, Bing Su, Hui Yang, Tomasz Herjan, Minjia Yu, Julie Carman, Ashok Dongre, Xing Chen, Xiaoxia Li, Thomas A. Hamilton, Xiao Li, Hao Zhou, Paul L. Fox, Lingzi Hong, Koichi Fukuda, Jonathan D. Smith, Junjie Zhao, Annette Flotho, Luke Qin, Han Wang, Gao Zhou, Frauke Melchior, Ji Gao, Zizhen Kang

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b416570bfc517f363be082f2fad510f4
https://doi.org/10.7554/elife.29630.039