Social buffering diminishes fear response but does not equal improved fear extinction

Autor: Tomasz Gorkiewicz, Konrad Danielewski, Karolina Andraka, Kacper Kondrakiewicz, Ksenia Meyza, Jan Kaminski, Ewelina Knapska

Publikováno v: Cerebral Cortex. 33:5007-5024

Social support during exposure-based psychotherapy is believed to diminish fear and improve therapy outcomes. However, some clinical trials challenge that notion. Underlying mechanisms remain unknown, hindering the understanding of benefits and pitfa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f97b862701287a3ce5b5b454c0699746
https://doi.org/10.1093/cercor/bhac395

c-Fos-MMP-9 pathway in central amygdala mediates approach motivation but not reward consumption

Autor: Tomasz Jaworski, Ksenia Z. Meyza, Leszek Kaczmarek, Tomasz Nikolaev, Ewelina Knapska, Dominik Kanigowski, Jakub M. Dzik, Tomasz Gorkiewicz, Tomasz Lebitko, Joanna Urban-Ciecko, Joanna Jędrzejewska-Szmek, Mayank Chaturvedi, Nowicka Klaudia

Although impaired motivational and consummatory aspects of reward behavior are core symptoms of several psychiatric disorders, the underlying neural and molecular mechanisms remain poorly understood. c-Fos, as a component of AP-1 transcription factor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cef5d60406b428dc7028d2fe8dde1211

Neuronal TDP-43 depletion affects activity-dependent plasticity

Autor: Lukasz Bijoch, Leszek Kaczmarek, Anna Beroun, Paulina Koza, Julio C. Torres, Anna Konopka, Ewa Bulska, Ewelina Knapska, Witold Konopka, Tomasz Gorkiewicz

Publikováno v: Neurobiology of Disease, Vol 130, Iss, Pp 104499-(2019)

TAR DNA-binding protein 43 (TDP-43) is a hallmark of some neurodegenerative disorders, such as frontotemporal lobar degeneration and amyotrophic lateral sclerosis. TDP-43-related pathology is characterized by its abnormally phosphorylated and ubiquit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a17a7ff3c44cecc1148b6f29e32c8c4e
http://www.sciencedirect.com/science/article/pii/S0969996119301548

Transient ECM protease activity promotes synaptic plasticity

Autor: Marta Magnowska, Jakub Wlodarczyk, Izabela Rutkowska-Wlodarczyk, Tomasz Gorkiewicz, Leszek Kaczmarek, Marcin Wawrzyniak, Anna Suska

Publikováno v: Scientific Reports

Activity-dependent proteolysis at a synapse has been recognized as a pivotal factor in controlling dynamic changes in dendritic spine shape and function; however, excessive proteolytic activity is detrimental to the cells. The exact mechanism of cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84a7ef731c468d6d895c0e46fd68caa3
https://pubmed.ncbi.nlm.nih.gov/27282248

Matrix metalloproteinase 9 (MMP-9) is indispensable for long term potentiation in the central and basal but not in the lateral nucleus of the amygdala

Autor: Leszek Kaczmarek, Tomasz Gorkiewicz, Marcin Balcerzyk, Ewelina Knapska

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Frontiers in Cellular Neuroscience
Frontiers in Cellular Neuroscience, Vol 9 (2015)
idUS. Depósito de Investigación de la Universidad de Sevilla

It has been shown that matrix metalloproteinase 9 (MMP-9) is required for synaptic plasticity, learning and memory. In particular, MMP-9 involvement in long-term potentiation (LTP, the model of synaptic plasticity) in the hippocampus and prefrontal c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb67a7327523daecefd402029b32e0bf
https://doi.org/10.3389/fncel.2015.00073