Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Tomasz Gawłowski"'
Autor:
Pawel Dudzic, Dawid Chomicz, Jarosław Kończak, Tadeusz Satława, Bartosz Janusz, Sonia Wrobel, Tomasz Gawłowski, Igor Jaszczyszyn, Weronika Bielska, Samuel Demharter, Roberto Spreafico, Lukas Schulte, Kyle Martin, Stephen R. Comeau, Konrad Krawczyk
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
The naïve human antibody repertoire has theoretical access to an estimated > 1015 antibodies. Identifying subsets of this prohibitively large space where therapeutically relevant antibodies may be found is useful for development of these agents. It
Externí odkaz:
https://doaj.org/article/7c74ae2f3b3c4564ab5b22c1be596002
Autor:
Dawid Chomicz, Jarosław Kończak, Sonia Wróbel, Tadeusz Satława, Paweł Dudzic, Bartosz Janusz, Mateusz Tarkowski, Piotr Deszyński, Tomasz Gawłowski, Anna Kostyn, Marek Orłowski, Tomasz Klaus, Lukas Schulte, Kyle Martin, Stephen R. Comeau, Konrad Krawczyk
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Antibodies are proteins produced by our immune system that have been harnessed as biotherapeutics. The discovery of antibody-based therapeutics relies on analyzing large volumes of diverse sequences coming from phage display or animal immunizations.
Externí odkaz:
https://doaj.org/article/bea9fd2ccdc045aba644a4813da35455
Autor:
Tadeusz Satława, Mateusz Tarkowski, Sonia Wróbel, Paweł Dudzic, Tomasz Gawłowski, Tomasz Klaus, Marek Orłowski, Anna Kostyn, Sandeep Kumar, Andrew Buchanan, Konrad Krawczyk
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 3, p e1011881 (2024)
Antibody-based therapeutics must not undergo chemical modifications that would impair their efficacy or hinder their developability. A commonly used technique to de-risk lead biotherapeutic candidates annotates chemical liability motifs on their sequ
Externí odkaz:
https://doaj.org/article/cff3dcbea5874d0a8c29f6bd8aadeb8d
Autor:
Igor Jaszczyszyn, Weronika Bielska, Tomasz Gawlowski, Pawel Dudzic, Tadeusz Satława, Jarosław Kończak, Wiktoria Wilman, Bartosz Janusz, Sonia Wróbel, Dawid Chomicz, Jacob D. Galson, Jinwoo Leem, Sebastian Kelm, Konrad Krawczyk
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
AlphaFold2 has hallmarked a generational improvement in protein structure prediction. In particular, advances in antibody structure prediction have provided a highly translatable impact on drug discovery. Though AlphaFold2 laid the groundwork for all
Externí odkaz:
https://doaj.org/article/b9bf830784aa46f6b4415c0e2d6b8f50