Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Tomasz Baginski"'
Autor:
Luis F. Schachner, Christopher Mullen, Wilson Phung, Joshua D. Hinkle, Michelle Irwin Beardsley, Tracy Bentley, Peter Day, Christina Tsai, Siddharth Sukumaran, Tomasz Baginski, Danielle DiCara, Nicholas J. Agard, Matthieu Masureel, Joshua Gober, Adel M. ElSohly, Rafael Melani, John E. P. Syka, Romain Huguet, Michael T. Marty, Wendy Sandoval
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The heterogeneity inherent in today’s biotherapeutics, especially as a result of heavy glycosylation, can affect a molecule’s safety and efficacy. Characterizing this heterogeneity is crucial for drug development and quality assessment,
Externí odkaz:
https://doaj.org/article/1f51a60ae7254824a781e70ff1592428
Autor:
Luis F. Schachner, Christopher Mullen, Wilson Phung, Joshua D. Hinkle, Michelle Irwin Beardsley, Tracy Bentley, Peter Day, Christina Tsai, Siddharth Sukumaran, Tomasz Baginski, Danielle DiCara, Nicholas Agard, Matthieu Masureel, Joshua Gober, Adel ElSohly, John E. P. Syka, Romain Huguet, Michael T. Marty, Wendy Sandoval
Glycosylated biotherapeutics are an emerging class of drugs with high molecular heterogeneity, which can affect their safety and efficacy. Characterizing this heterogeneity is crucial for drug development and quality assessment, but existing methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df06bf053a921f4b232ad59ea02b7183
https://doi.org/10.21203/rs.3.rs-2928767/v1
https://doi.org/10.21203/rs.3.rs-2928767/v1
Autor:
Mark X. Sliwkowski, Robert F. Kelley, Klara Totpal, Gloria Meng, Tomasz Baginski, Oliver Pabonan, Lisa Crocker, Julie Theriault, Yan Xin, Yanmei Lu, Christine Olsson, Kathryn Parsons, Teemu T. Junttila
Supplementary Data 1 from Superior In vivo Efficacy of Afucosylated Trastuzumab in the Treatment of HER2-Amplified Breast Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50694fc9364b86439dad0b037c634fe7
https://doi.org/10.1158/0008-5472.22383927
https://doi.org/10.1158/0008-5472.22383927
Autor:
Mark X. Sliwkowski, Robert F. Kelley, Klara Totpal, Gloria Meng, Tomasz Baginski, Oliver Pabonan, Lisa Crocker, Julie Theriault, Yan Xin, Yanmei Lu, Christine Olsson, Kathryn Parsons, Teemu T. Junttila
The enhancement of immune effector functions has been proposed as a potential strategy for increasing the efficacy of therapeutic antibodies. Here, we show that removing fucose from trastuzumab (Herceptin) increased its binding to FcγRIIIa, enhanced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2c0218a1a1596c0112f57097b3a0fef
https://doi.org/10.1158/0008-5472.c.6500709
https://doi.org/10.1158/0008-5472.c.6500709
Autor:
Mark X. Sliwkowski, Robert F. Kelley, Klara Totpal, Gloria Meng, Tomasz Baginski, Oliver Pabonan, Lisa Crocker, Julie Theriault, Yan Xin, Yanmei Lu, Christine Olsson, Kathryn Parsons, Teemu T. Junttila
Supplementary Figure Legends 1-3 from Superior In vivo Efficacy of Afucosylated Trastuzumab in the Treatment of HER2-Amplified Breast Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93342bb6870d9d13707806209724ce47
https://doi.org/10.1158/0008-5472.22383921.v1
https://doi.org/10.1158/0008-5472.22383921.v1
Autor:
Mark X. Sliwkowski, Robert F. Kelley, Klara Totpal, Gloria Meng, Tomasz Baginski, Oliver Pabonan, Lisa Crocker, Julie Theriault, Yan Xin, Yanmei Lu, Christine Olsson, Kathryn Parsons, Teemu T. Junttila
Supplementary Data 2 from Superior In vivo Efficacy of Afucosylated Trastuzumab in the Treatment of HER2-Amplified Breast Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::301029c6f3f63bcf244b3829a8b51783
https://doi.org/10.1158/0008-5472.22383924.v1
https://doi.org/10.1158/0008-5472.22383924.v1
SuperiorIn vivoEfficacy of Afucosylated Trastuzumab in the Treatment of HER2-Amplified Breast Cancer
Autor:
Teemu T. Junttila, Mark X. Sliwkowski, Oliver Pabonan, Klara Totpal, Tomasz Baginski, Julie Theriault, Christine Olsson, Lisa Crocker, Kathryn Parsons, Robert F. Kelley, Gloria Meng, Yanmei Lu, Yan Xin
Publikováno v:
Cancer Research. 70:4481-4489
The enhancement of immune effector functions has been proposed as a potential strategy for increasing the efficacy of therapeutic antibodies. Here, we show that removing fucose from trastuzumab (Herceptin) increased its binding to FcγRIIIa, enhanced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ccfc3dfd74da58d484dcabec7a75632
https://doi.org/10.1158/0008-5472.can-09-3704
https://doi.org/10.1158/0008-5472.can-09-3704
Publikováno v:
Development, growthdifferentiation. 41(3)
In the ascidian Halocynthia roretzi, sperm-egg binding is probably mediated through the interaction between alpha-L-fucosidase present on the sperm surface and anionic saccharide chains of the egg vitelline coat. To characterize biologically active g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3814d26a13388b525e5253cd04a4195f
https://pubmed.ncbi.nlm.nih.gov/10400397
https://pubmed.ncbi.nlm.nih.gov/10400397