Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Tomasz, Misztal"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Relatively low levels of antioxidant enzymes coupled with high oxygen metabolism result in the formation of numerous oxidative DNA damages in the tissues of the central nervous system. Recently, kynurenic acid (KYNA), knowns for its neuropro
Externí odkaz:
https://doaj.org/article/ae9cd96413e2455c9c72c28131c31a6f
Autor:
Katarzyna Roszkowicz-Ostrowska, Patrycja Młotkowska, Elżbieta Marciniak, Michał Szlis, Marcin Barszcz, Tomasz Misztal
Publikováno v:
Cells, Vol 13, Iss 23, p 1928 (2024)
Fluctuations in kynurenic acid (KYNA) and brain-derived neurotrophic factor (BDNF) levels in the brain reflect its neurological status. The aim of the study was to investigate the effect of transiently elevated KYNA concentrations in the cerebroventr
Externí odkaz:
https://doaj.org/article/827ca9c9e9ff4b63a6cd729b2786ad0d
Publikováno v:
In Biomedicine & Pharmacotherapy 31 December 2023 169
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
The short form of the leptin receptor (LeptRa) plays a key role in the transport of leptin to the central nervous system (CNS). Here, MTS-leptin and recombinant ovine (ro) leptin-mediated expression of LeptRa and VEGFA and VEGFR2 concentration in sel
Externí odkaz:
https://doaj.org/article/93a90a319c1f4687b61ae5ff7ae06a82
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are antihyperglycemic drugs that decrease mortality from cardiovascular diseases. However, their effects on hemostasis in the cardioprotective effects have not been evaluated. Therefore, the
Externí odkaz:
https://doaj.org/article/97567da37d384bccabe479389696faac
Publikováno v:
Animals, Vol 13, Iss 10, p 1658 (2023)
Oxytocin (OT) is a neuropeptide synthesized in the hypothalamic nuclei that modulates both behavioral and reproductive functions, associated with the increased neurosteroid synthesis in the brain. Therefore, the present study tested the hypothesis th
Externí odkaz:
https://doaj.org/article/ab0770749cac4938b752aa84f7b49aef
Autor:
Natalia Marcinczyk, Agata Gołaszewska, Anna Gromotowicz-Poplawska, Tomasz Misztal, Jakub Strawa, Michał Tomczyk, Irena Kasacka, Ewa Chabielska
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
In our previous study, we showed that ellagitannin- and procyanidin-rich tormentil extract (TE) decreased experimental arterial thrombosis in normoglycemic rats through platelet inhibition. TE also slightly increased coagulation and attenuated fibrin
Externí odkaz:
https://doaj.org/article/74cede3edefb45ff8ab8257294adf802
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Background: Adrenaline is believed to play a role in thrombosis and hemostasis. The complex effect of its clinically relevant concentrations on thrombus formation, coagulation and fibrinolysis in human blood has never been specifically studied.Method
Externí odkaz:
https://doaj.org/article/efcdd7a6556e480a8680055871f354b1
Autor:
Tomasz Misztal, Agata Golaszewska, Justyna Branska-Januszewska, Natalia Marcinczyk, Ewa Chabielska, Marian Tomasiak, Tomasz Rusak
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Background: Recent studies indicate that aquaporin (AQP) water channels have a regulatory function in human platelet secretion and in procoagulant response of murine platelets. However, the engagement of AQPs in morphological changes, procoagulant re
Externí odkaz:
https://doaj.org/article/58294802ff9a4d66b79a27b1bd2c8de4
Autor:
Tomasz Misztal, Agata Golaszewska, Natalia Marcińczyk, Maria Tomasiak-Łozowska, Małgorzata Szymanowska, Ewa Chabielska, Tomasz Rusak
Publikováno v:
Antioxidants, Vol 11, Iss 4, p 779 (2022)
During pathogen invasion, activated neutrophils secrete myeloperoxidase (MPO), which generates high local concentrations of hypochlorous acid (HOCl), a strong antimicrobial agent. Prolonged or uncontrolled HOCl production may, however, affect hemosta
Externí odkaz:
https://doaj.org/article/8e4c2afcf0b2454fb2a085d81a9bc480