Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Tomasz, Lenda"'
Publikováno v:
Molecules, Vol 29, Iss 18, p 4318 (2024)
The use of phosphodiesterase inhibitors in the treatment of Parkinson’s disease is currently widely discussed. The study aimed to investigate the impact of acute and chronic treatment with the phosphodiesterase 5 inhibitor, sildenafil, at low and m
Externí odkaz:
https://doaj.org/article/f595e0c42e4d4726951a7470aea19758
Publikováno v:
Psychopharmacology. 239:3633-3656
Rationale The pharmacological effects of antidepressants in modulating noradrenergic transmission as compared to serotonergic transmission in a rat model of Parkinson’s disease under chronic L-DOPA therapy are insufficiently explored. Objectives Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8ac9270762221cd80baf35aad094a2a
https://doi.org/10.1007/s00213-022-06238-x
https://doi.org/10.1007/s00213-022-06238-x
Autor:
Agata Hogendorf, Adam S. Hogendorf, Rafał Kurczab, Grzegorz Satała, Bernadeta Szewczyk, Paulina Cieślik, Gniewomir Latacz, Jadwiga Handzlik, Tomasz Lenda, Katarzyna Kaczorowska, Jakub Staroń, Ryszard Bugno, Beata Duszyńska, Andrzej J. Bojarski
Publikováno v:
Molecules, Vol 26, Iss 15, p 4605 (2021)
A series of N-skatyltryptamines was synthesized and their affinities for serotonin and dopamine receptors were determined. Compounds exhibited activity toward 5-HT1A, 5-HT2A, 5-HT6, and D2 receptors. Substitution patterns resulting in affinity/activi
Externí odkaz:
https://doaj.org/article/161dfe1128284230be1a6f666c15721d
Autor:
Adam S. Hogendorf, Agata Hogendorf, Rafał Kurczab, Grzegorz Satała, Tomasz Lenda, Maria Walczak, Gniewomir Latacz, Jadwiga Handzlik, Katarzyna Kieć-Kononowicz, Joanna M. Wierońska, Monika Woźniak, Paulina Cieślik, Ryszard Bugno, Jakub Staroń, Andrzej J. Bojarski
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract A series of 5-aryl-1-alkylimidazole derivatives was synthesized using the van Leusen multicomponent reaction. The chemotype is the first example of low-basicity scaffolds exhibiting high affinity for 5-HT7 receptor together with agonist func
Externí odkaz:
https://doaj.org/article/b2815ce3d4e34da783160c0d85d688cb
Autor:
Jolanta Konieczny, Tomasz Lenda, Krystyna Ossowska, Klemencja Berghauzen-Maciejewska, Barbara Kosmowska, Jadwiga Wardas
Publikováno v:
Neuroscience. 429:106-118
The primary cause of harmaline tremor, which is a model of essential tremor (ET) in animals, is excessive activation of olivocerebellar glutamatergic climbing fibers. Our recent study indicated that 5′-chloro-5′-deoxy-(±)-N6-(±)-(endo-norborn-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c667f65745b81100fdd992a303a4537
https://doi.org/10.1016/j.neuroscience.2019.12.045
https://doi.org/10.1016/j.neuroscience.2019.12.045
Publikováno v:
Neurochemistry International. 121:125-139
Antidepressant drugs are recommended for the treatment of Parkinson's disease (PD)-associated depression but their role in the modulation of L-DOPA-induced behavioral and neurochemical markers is poorly explored. The aim of the present study was to e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce31d4336247a33f3d82b28db68c28f0
https://doi.org/10.1016/j.neuint.2018.10.004
https://doi.org/10.1016/j.neuint.2018.10.004
Autor:
Klemencja Berghauzen-Maciejewska, Tomasz Lenda, Jolanta Konieczny, Maciej Wieczorek, Jerzy Pieczykolan, Krystyna Ossowska, Mikołaj Matłoka
Publikováno v:
European journal of pharmacology. 910
Phosphodiesterase 10A (PDE10A), the enzyme which catalyzes hydrolysis of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), is located almost exclusively in striatal γ-amino-butyric acid (GABA)ergic medium spiny neurons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c72808b007fbcd7f0b9ac564b10dac03
https://pubmed.ncbi.nlm.nih.gov/34469756
https://pubmed.ncbi.nlm.nih.gov/34469756
Autor:
Jakub, Staroń, Ryszard, Bugno, Wojciech, Pietruś, Grzegorz, Satała, Stefan, Mordalski, Dawid, Warszycki, Agata, Hogendorf, Adam S, Hogendorf, Justyna, Kalinowska-Tłuścik, Tomasz, Lenda, Bogusław, Pilarski, Andrzej J, Bojarski
Publikováno v:
European journal of medicinal chemistry. 209
Among all of the monoaminergic receptors, the 5-HT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a6b115ec002170e3812039fd9e3cda87
https://pubmed.ncbi.nlm.nih.gov/33328102
https://pubmed.ncbi.nlm.nih.gov/33328102
Autor:
Katarzyna Stachowicz, Patrycja Patrycja Pańczyszyn-Trzewik, Szymon Rzeźniczek, Tomasz Lenda, Magdalena Sowa-Kućma, Paulina Misztak
Publikováno v:
Neurochemistry International. 150:105193
Imipramine belongs to a group of tricyclic antidepressants (TCAs). It has been also documented that its antidepressant activity connects with the modulation of cytosolic phospholipase A2 (cPLA2) and arachidonic acid (AA) turnover. Through this mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d0b33f181d92ca0f594719621c237a6
https://doi.org/10.1016/j.neuint.2021.105193
https://doi.org/10.1016/j.neuint.2021.105193
Autor:
Dawid Warszycki, Ryszard Bugno, Agata Hogendorf, Rafał Kurczab, Beata Duszyńska, Adam S. Hogendorf, Andrzej J. Bojarski, Wojciech Pietruś, Tomasz Lenda, Jakub Staroń, Grzegorz Satała, Anna Wantuch
Publikováno v:
European Journal of Medicinal Chemistry. 220:113533
The selective serotonin reuptake inhibitors (SSRIs), acting at the serotonin transporter (SERT), are one of the most widely prescribed antidepressant medications. All five approved SSRIs possess either fluorine or chlorine atoms, and there is a limit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92afc552b4b8acf7ae6d6795197acdc8
https://doi.org/10.1016/j.ejmech.2021.113533
https://doi.org/10.1016/j.ejmech.2021.113533