A first-in-class Wiskott-Aldrich syndrome protein activator with antitumor activity in hematologic cancers.

Autor: Spriano F; Institute of Oncology Research, Faculty of Biomedical Sciences, USI, Bellinzona., Sartori G; Institute of Oncology Research, Faculty of Biomedical Sciences, USI, Bellinzona., Sgrignani J; Institute of Research in Biomedicine, Faculty of Biomedical Sciences, USI, Bellinzona., Barnabei L; Institute of Oncology Research, Faculty of Biomedical Sciences, USI, Bellinzona., Arribas AJ; Institute of Oncology Research, Faculty of Biomedical Sciences, USI, Bellinzona, Switzerland; SIB Swiss Institute of Bioinformatics, Lausanne., Guala M; Chimete, Tortona., Del Amor AMC; Department of Biomedical and Clinical Sciences, Cell Biology, Medical Faculty, Linköping University, Linköping., Tomasso MR; Drexel University, College of Medicine, Department of Biochemistry and Molecular Biology, Philadelphia, PA., Tarantelli C; Institute of Oncology Research, Faculty of Biomedical Sciences, USI, Bellinzona., Cascione L; Institute of Oncology Research, Faculty of Biomedical Sciences, USI, Bellinzona, Switzerland; SIB Swiss Institute of Bioinformatics, Lausanne., Golino G; Institute of Oncology Research, Faculty of Biomedical Sciences, USI, Bellinzona, Switzerland; Department of Pharmacy, University of Napoli Federico II, Napoli., Riveiro ME; Early Drug Development Group, Boulogne-Billancourt., Bortolozzi R; Department of Woman's and Child's Health, University of Padova, Italy; Istituto di Ricerca Pediatrica IRP, Fondazione Città della Speranza, Padova., Lupia A; Department of Pharmacy, University of Napoli Federico II, Napoli, Italy; Net4science Srl, Magna Graecia University of Catanzaro, Catanzaro., Paduano F; University 'Magna Græcia' of Catanzaro, Catanzaro, Italy; Tecnologica Research Institute and Marrelli Health, Biomedical Section, Stem Cells and Medical Genetics Units, Crotone., Huguet S; Institut Curie, Paris., Rezai K; Institut Curie, Paris., Rinaldi A; Institute of Oncology Research, Faculty of Biomedical Sciences, USI, Bellinzona., Margheriti F; Institute of Oncology Research, Faculty of Biomedical Sciences, USI, Bellinzona., Ventura P; Institute of Research in Biomedicine, Faculty of Biomedical Sciences, USI, Bellinzona., Guarda G; Institute of Research in Biomedicine, Faculty of Biomedical Sciences, USI, Bellinzona., Costa G; University 'Magna Græcia' of Catanzaro, Catanzaro., Rocca R; University 'Magna Græcia' of Catanzaro, Catanzaro., Furlan A; Institute of Research in Biomedicine, Faculty of Biomedical Sciences, USI, Bellinzona., Verdonk LM; Biological Chemistry Group, Institute of Biology Leiden, Leiden University, Leiden., Innocenti P; Biological Chemistry Group, Institute of Biology Leiden, Leiden University, Leiden., Martin NI; Biological Chemistry Group, Institute of Biology Leiden, Leiden University, Leiden., Viola G; Department of Woman's and Child's Health, University of Padova, Italy; Istituto di Ricerca Pediatrica IRP, Fondazione Città della Speranza, Padova., Driessen C; Kantosspital St Gallen, St Gallen., Zucca E; Institute of Oncology Research, Faculty of Biomedical Sciences, USI, Bellinzona, Switzerland; Oncology Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona., Stathis A; Oncology Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona., Gahtory D; BIMINI Biotech B.V., Leiden., Van den Nieuwboer M; BIMINI Biotech B.V., Leiden., Bornhauser B; Children's Hospital Zurich, Zurich., Alcaro S; University 'Magna Græcia' of Catanzaro, Catanzaro., Trapasso F; University 'Magna Græcia' of Catanzaro, Catanzaro., Cristobal S; Department of Biomedical and Clinical Sciences, Cell Biology, Medical Faculty, Linköping University, Linköping, Sweden; Ikerbasque, Basque Foundation for Sciences, Department of Department of Physiology, Faculty of Medicine and Nursing, University of the Basque Country., Padrick SB; Drexel University, College of Medicine, Department of Biochemistry and Molecular Biology, Philadelphia, PA., Pazzi N; Chimete, Tortona., Cavalli F; Institute of Oncology Research, Faculty of Biomedical Sciences, USI, Bellinzona., Cavalli A; Institute of Research in Biomedicine, Faculty of Biomedical Sciences, USI, Bellinzona., Gaudio E; Institute of Oncology Research, Faculty of Biomedical Sciences, USI, Bellinzona. eugaudio1976@gmail.com., Bertoni F; Institute of Oncology Research, Faculty of Biomedical Sciences, USI, Bellinzona, Switzerland; Oncology Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona. francesco.bertoni@ior.usi.ch.

Publikováno v: Haematologica [Haematologica] 2024 Nov 01; Vol. 109 (11), pp. 3602-3614. Date of Electronic Publication: 2024 Nov 01.

Septins mediate a microtubule-actin crosstalk that enables actin growth on microtubules.

Autor: Nakos K; Department of Biology, Drexel University, Philadelphia, PA 19104., Alam MNA; Department of Biology, Drexel University, Philadelphia, PA 19104., Radler MR; Department of Biology, Drexel University, Philadelphia, PA 19104., Kesisova IA; Department of Biology, Drexel University, Philadelphia, PA 19104., Yang C; Department of Biology, University of Pennsylvania, Philadelphia, PA 19104., Okletey J; Department of Biology, Drexel University, Philadelphia, PA 19104., Tomasso MR; Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA 19102., Padrick SB; Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA 19102., Svitkina TM; Department of Biology, University of Pennsylvania, Philadelphia, PA 19104., Spiliotis ET; Department of Biology, Drexel University, Philadelphia, PA 19104.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Dec 13; Vol. 119 (50), pp. e2202803119. Date of Electronic Publication: 2022 Dec 07.