Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy.

Autor: Prieto-Garcia C; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany., Matkovic V; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany.; Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Frankfurt, Germany., Mosler T; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany.; Institute of Molecular Biology (IMB), Mainz, Germany., Li C; Department of Systems Biology and Stuttgart Research Center Systems Biology (SRCSB), University of Stuttgart, Stuttgart, Germany., Liang J; Max Planck Institute for Heart and Lung Research, Department of Developmental Genetics, Bad Nauheim, Germany.; German Centre for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Bad Nauheim, Germany.; Cardio-Pulmonary Institute (CPI), Bad Nauheim, Germany., Oo JA; Institute for Cardiovascular Physiology, Goethe University Frankfurt, Frankfurt, Germany.; German Centre of Cardiovascular Research (DZHK), Partner Site Rhine-Main, Frankfurt, Germany.; Cardiopulmonary Institute (CPI), Goethe University Frankfurt, Frankfurt, Germany., Haidle F; Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Frankfurt, Germany.; Institute of Molecular Biosciences, Goethe University Frankfurt, Frankfurt, Germany., Mačinković I; Institute of Biochemistry I, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany., Cabrera-Orefice A; Institute for Cardiovascular Physiology, Goethe University Frankfurt, Frankfurt, Germany.; Center for Functional Proteomics, Goethe University Frankfurt, Frankfurt, Germany., Berkane R; Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Frankfurt, Germany., Giuliani G; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany., Xu F; School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, P.R. China.; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, P.R. China., Jacomin AC; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany., Tomaskovic I; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany., Basoglu M; Institute of Cell Biology and Neuroscience, Goethe University Frankfurt, Frankfurt, Germany., Hoffmann ME; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany., Rathore R; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany., Cetin R; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany., Boutguetait D; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany.; Institute of Molecular Systems Medicine, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany., Bozkurt S; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany.; Institute of Molecular Systems Medicine, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany., Hernández Cañás MC; Institute of Molecular Biosciences, Goethe University Frankfurt, Frankfurt, Germany., Keller M; Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Frankfurt, Germany.; Institute of Molecular Biosciences, Goethe University Frankfurt, Frankfurt, Germany., Busam J; Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Frankfurt, Germany.; Institute of Molecular Biosciences, Goethe University Frankfurt, Frankfurt, Germany., Shah VJ; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany., Wittig I; Institute for Cardiovascular Physiology, Goethe University Frankfurt, Frankfurt, Germany.; German Centre of Cardiovascular Research (DZHK), Partner Site Rhine-Main, Frankfurt, Germany.; Center for Functional Proteomics, Goethe University Frankfurt, Frankfurt, Germany., Kaulich M; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany., Beli P; Institute of Molecular Biology (IMB), Mainz, Germany.; Institute of Developmental Biology and Neurobiology (IDN), Johannes Gutenberg-University, Mainz, Germany., Galej WP; European Molecular Biology Laboratory (EMBL), Grenoble, France., Ebersberger I; Applied Bioinformatics Group, Institute of Cell Biology and Neuroscience, Goethe University Frankfurt, Frankfurt, Germany.; Senckenberg Biodiversity and Climate Research Centre (S-BIK-F), Frankfurt, Germany.; LOEWE Centre for Translational Biodiversity Genomics (TBG), Frankfurt, Germany., Wang L; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, P.R. China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, P.R. China., Münch C; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany.; Center for Functional Proteomics, Goethe University Frankfurt, Frankfurt, Germany.; Institute of Molecular Systems Medicine, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany., Stolz A; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany.; Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Frankfurt, Germany., Brandes RP; Institute for Cardiovascular Physiology, Goethe University Frankfurt, Frankfurt, Germany.; German Centre of Cardiovascular Research (DZHK), Partner Site Rhine-Main, Frankfurt, Germany.; Cardiopulmonary Institute (CPI), Goethe University Frankfurt, Frankfurt, Germany., Tse WKF; Laboratory of Developmental Disorders and Toxicology, Center for Promotion of International Education and Research, Faculty of Agriculture, Kyushu University, Fukuoka, Japan., Eimer S; Institute of Cell Biology and Neuroscience, Goethe University Frankfurt, Frankfurt, Germany., Stainier DYR; Max Planck Institute for Heart and Lung Research, Department of Developmental Genetics, Bad Nauheim, Germany.; German Centre for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Bad Nauheim, Germany.; Cardio-Pulmonary Institute (CPI), Bad Nauheim, Germany., Legewie S; Department of Systems Biology and Stuttgart Research Center Systems Biology (SRCSB), University of Stuttgart, Stuttgart, Germany., Zarnack K; Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Frankfurt, Germany.; Institute of Molecular Biosciences, Goethe University Frankfurt, Frankfurt, Germany., Müller-McNicoll M; Institute of Molecular Biosciences, Goethe University Frankfurt, Frankfurt, Germany.; Max-Planck Institute for Biophysics, Frankfurt, Germany., Dikic I; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany.; Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Frankfurt, Germany.; Max-Planck Institute for Biophysics, Frankfurt, Germany.

Publikováno v: Science (New York, N.Y.) [Science] 2024 Nov 15; Vol. 386 (6723), pp. 768-776. Date of Electronic Publication: 2024 Nov 14.

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Chronic prostatitis/chronic pelvic pain syndrome in males may be an autoimmune disease, potentially responsive to corticosteroid therapy

Autor: Tomaskovic, I., Ruzic, B., Trnski, D., Kraus, O.

Publikováno v: In Medical Hypotheses 2009 72(3):261-262

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