Botulinum Neurotoxin Chimeras Suppress Stimulation by Capsaicin of Rat Trigeminal Sensory Neurons In Vivo and In Vitro

Autor: Caren Antoniazzi, Mariia Belinskaia, Tomas Zurawski, Seshu Kumar Kaza, J. Oliver Dolly, Gary W. Lawrence

Publikováno v: Toxins, Vol 14, Iss 2, p 116 (2022)

Chimeras of botulinum neurotoxin (BoNT) serotype A (/A) combined with /E protease might possess improved analgesic properties relative to either parent, due to inheriting the sensory neurotropism of the former with more extensive disabling of SNAP-25

Externí odkaz: https://doaj.org/article/f8c450e2c352418793501911c8d10c07

NGF Enhances CGRP Release Evoked by Capsaicin from Rat Trigeminal Neurons: Differential Inhibition by SNAP-25-Cleaving Proteases

Autor: Mariia Belinskaia, Tomas Zurawski, Seshu Kumar Kaza, Caren Antoniazzi, J. Oliver Dolly, Gary W. Lawrence

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 2; Pages: 892
International Journal of Molecular Sciences, Vol 23, Iss 892, p 892 (2022)
International Journal of Molecular Sciences

Nerve growth factor (NGF) is known to intensify pain in various ways, so perturbing pertinent effects without negating its essential influences on neuronal functions could help the search for much-needed analgesics. Towards this goal, cultured neuron

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::357374a15cabb47b412fe0c971cd10e8
https://doi.org/10.3390/ijms23020892