Differential regulation of β-catenin-mediated transcription via N- and C-terminal co-factors governs identity of murine intestinal epithelial stem cells

Autor: Costanza Borrelli, Tomas Valenta, Kristina Handler, Karelia Vélez, Alessandra Gurtner, Giulia Moro, Atefeh Lafzi, Laura de Vargas Roditi, George Hausmann, Isabelle C. Arnold, Andreas E. Moor, Konrad Basler

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)

How downstream regulators of Wnt/β-catenin signalling control the fate of intestinal epithelial stem cells (IESCs) is unclear. Here, the authors show that the transcriptional co-factors interacting with the N- and C-terminal domains of β-catenin di

Externí odkaz: https://doaj.org/article/b000084e9fe54599bffafb79714d42b4

Distinct populations of crypt-associated fibroblasts act as signaling hubs to control colon homeostasis.

Autor: Michael David Brügger, Tomas Valenta, Hassan Fazilaty, George Hausmann, Konrad Basler

Publikováno v: PLoS Biology, Vol 18, Iss 12, p e3001032 (2020)

Despite recent progress in recognizing the importance of mesenchymal cells for the homeostasis of the intestinal system, the current picture of how these cells communicate with the associated epithelial layer remains unclear. To describe the relevant

Externí odkaz: https://doaj.org/article/14cd48285cd449da9609da6ac52b7753

β-Catenin C-terminal signals suppress p53 and are essential for artery formation

Autor: Dario F. Riascos-Bernal, Prameladevi Chinnasamy, Longyue (Lily) Cao, Charlene M. Dunaway, Tomas Valenta, Konrad Basler, Nicholas E. S. Sibinga

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)

How p53 is restrained in arterial maturation during embryonic development is unclear. Here, the authors show that β-catenin C-terminal interactions inhibit CREB binding protein-mediated acetylation and activation of p53 in smooth muscle cells, and t

Externí odkaz: https://doaj.org/article/714f114658344539a951b80874578064

BCL9/9L-β-catenin Signaling is Associated With Poor Outcome in Colorectal Cancer

Autor: Andreas E. Moor, Pascale Anderle, Claudio Cantù, Patrick Rodriguez, Norbert Wiedemann, Frédérique Baruthio, Jürgen Deka, Sylvie André, Tomas Valenta, Matthias B. Moor, Balázs Győrffy, David Barras, Mauro Delorenzi, Konrad Basler, Michel Aguet

Publikováno v: EBioMedicine, Vol 2, Iss 12, Pp 1932-1943 (2015)

BCL9/9L proteins enhance the transcriptional output of the β-catenin/TCF transcriptional complex and contribute critically to upholding the high WNT signaling level required for stemness maintenance in the intestinal epithelium. Here we show that a

Externí odkaz: https://doaj.org/article/5d9510d1efc34bd0921ecd2bd9e0e19e

Active eosinophils regulate host defense and immune responses in colitis

Autor: Alessandra Gurtner, Costanza Borrelli, Ignacio Gonzalez-Perez, Karsten Bach, Ilhan E. Acar, Nicolás G. Núñez, Daniel Crepaz, Kristina Handler, Vivian P. Vu, Atefeh Lafzi, Kristin Stirm, Deeksha Raju, Julia Gschwend, Konrad Basler, Christoph Schneider, Emma Slack, Tomas Valenta, Burkhard Becher, Philippe Krebs, Andreas E. Moor, Isabelle C. Arnold

Publikováno v: Gurtner, Alessandra; Borrelli, Costanza; Gonzalez-Perez, Ignacio; Bach, Karsten; Acar, Ilhan E; Núñez, Nicolás G; Crepaz, Daniel; Handler, Kristina; Vu, Vivian P; Lafzi, Atefeh; Stirm, Kristin; Raju, Deeksha; Gschwend, Julia; Basler, Konrad; Schneider, Christoph; Slack, Emma; Valenta, Tomas; Becher, Burkhard; Krebs, Philippe; Moor, Andreas E; ... (2023). Active eosinophils regulate host defense and immune responses in colitis. Nature, 615(7950), pp. 151-157. Macmillan Journals Ltd. 10.1038/s41586-022-05628-7
Nature, 615 (7950)

In the past decade, single-cell transcriptomics has helped uncover new cell types and states and led to the construction of a cellular compendium of health and disease. Still, some difficult-to-sequence cells remain absent from tissue atlases. Eosino

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80d83f3cd3ccfa323f6d74bb007f5fc2
https://boris.unibe.ch/175775/1/s41586-022-05628-7_reference.pdf