Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Tomas Mow"'
Autor:
Alan S. Bass, David Jones, Derek J. Leishman, Siddhartha Bhatt, Martin Traebert, Nils Dragsted, Jean-Pierre Valentin, Theodore J. Baird, Simon Authier, Ninette K. Andersen, Tomas Mow, Carrie Markgraf, Anders B. Lassen, Michael J. Curtis, Morten Laursen
Publikováno v:
Journal of pharmacological and toxicological methods. 105
In nonclinical toxicology the highest dose or exposure without test article-related adverse effects, known as the No Observed Adverse Effect Level (NOAEL), is a variable that may be determined. In safety pharmacology the vast majority of the endpoint
Autor:
J.-P. Valentin, William S. Redfern, Hugo M. Vargas, Michael K. Pugsley, Andrea Greiter-Wilke, Maxim Soloviev, Simon Authier, Tiffini Brabham, J.E. Koerner, Derek J. Leishman, Krystle Correll, Mike Engwall, Carrie Markgraf, Tomas Mow, Alfred Botchway, Martin Traebert
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 93:35-45
Safety Pharmacology studies are conducted to characterize the confidence by which biologically active new chemical entities (NCE) may be anticipated as safe. Non-clinical safety pharmacology studies aim to detect and characterize potentially undesira
Autor:
Ulf Simonsen, Christoffer Bundgaard, Tomas Mow, Susie Mogensen, Estéfano Pinilla, Morten Grunnet, Jan Kehler, Morten Laursen, Claus Tornby Christoffersen, Lilliana Beck, Jakob S. Knudsen, Elise R. Hedegaard
Publikováno v:
British Journal of Pharmacology. 174:2563-2575
Background and purpose Phosphodiesterase enzymes (PDE1-11) break down cyclic nucleotides and are important in the regulation of the cardiovascular system. The purpose of the present study was to investigate the effect on the cardiovascular system of
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 86:12-18
Introduction The Gottingen minipig is a promising model for pharmacological safety assessment and for translational research in cardiology. We have examined the main ion currents in cardiomyocytes of the minipig heart. Methods Cardiac cells were isol
Publikováno v:
European Journal of Pharmacology. 748:10-17
Torsades de Pointes (TdP) is a potentially lethal cardiac arrhythmia and a known adverse effect of many drugs secondary to block of the rapidly activating delayed rectifier potassium current (IKr). In animal models antipsychotic drugs have shown redu
Publikováno v:
Environmental and Molecular Mutagenesis. 55:704-718
Genotoxicity is an unacceptable property for new drug candidates and we employ three screening assays during the drug discovery process to identify genotoxicity early and optimize chemical series. One of these methods is the flow cytometric in vitro
Autor:
Morten Laursen, Nina Brenden, Jorrit J. Hornberg, Dorthe Bach Toft, Tomas Mow, Annemette V. Thougaard, Mikael Persson
Publikováno v:
Drug Discovery Today. 19:1137-1144
In an effort to reduce toxicity-related attrition, different strategies have been implemented throughout the pharmaceutical industry. Previously (in Part I), we have outlined our 'integrated toxicology' strategy, which aims to provide timely go/no-go
Autor:
Mikael Persson, Dorthe Bach Toft, Annemette V. Thougaard, Morten Laursen, Jorrit J. Hornberg, Tomas Mow, Nina Brenden
Publikováno v:
Drug Discovery Today. 19:1131-1136
Toxicity and clinical safety have major impact on drug development success. Moving toxicological studies into earlier phases of the R&D chain prevents drug candidates with a safety risk from entering clinical development. However, to identify candida
Autor:
Mikael Persson, Natacha S. Mow, Jorrit J. Hornberg, Anni F. Løye, Tomas Mow, Annemette V. Thougaard, Mélanie Jacquet
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 115:18-23
High-content imaging/analysis has emerged as a powerful tool for predictive toxicology as it can be used for identifying and mitigating potential safety risks during drug discovery. By careful selection of end-points, some cellular assays can show be
Autor:
Michael J. Engwall, Simon Authier, Morten Laursen, Michael J. Curtis, Siddhartha Bhatt, Derek J. Leishman, Martin Traebert, Ninette K. Andersen, Alan S. Bass, David K. Jones, Tomas Mow, Carrie G. Markgraf, Theodore J. Baird, Nils Dragsted, Anders B. Lassen, Jean-Pierre Valentin, Zindy Raida
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 93:172-173