Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Tomas Leek"'
Autor:
Frank Wesche, Leonardo De Maria, Tomas Leek, Frank Narjes, James Bird, Wu Su, Werngard Czechtizky
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 224
Peptides and peptide drug conjugates are emerging modalities to treat pulmonary diseases. Peptides are susceptible to proteolytic cleavage. Expression levels of specific proteases in the lung can be significantly increased in disease state and may le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb95b3c2dc2f7a32e127f5ec5c07e536
https://pubmed.ncbi.nlm.nih.gov/36463768
https://pubmed.ncbi.nlm.nih.gov/36463768
Autor:
Lauren M. Reid, Ileana Guzzetti, Tor Svensson, Anna-Carin Carlsson, Wu Su, Tomas Leek, Lena von Sydow, Werngard Czechtizky, Marija Miljak, Chandra Verma, Leonardo De Maria, Jonathan W. Essex
Understanding the conformational ensembles of intrinsically disordered proteins and peptides (IDPs) in their various biological environments is essential for understanding their mechanisms and functional roles in the proteome, leading to a greater kn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9a5a94ae847564f22dba11030a6f854
https://eprints.soton.ac.uk/455486/
https://eprints.soton.ac.uk/455486/
Autor:
Frank Wesche, Leonardo De Maria, Tomas Leek, Frank Narjes, James Bird, Wu Su, Werngard Czechtizky
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 211
The inhalation of peptides comes with the advantage of directly targeting the lung as tissue of interest. However, peptides are often rapidly metabolized in lung tissue through proteolytic cleavage. We have developed an assay workflow to obtain half-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::013da02e6503d69530baf361496f972f
https://pubmed.ncbi.nlm.nih.gov/35124452
https://pubmed.ncbi.nlm.nih.gov/35124452
Autor:
Torgny Fornstedt, Krzysztof Kaczmarski, Annika Langborg Weinmann, Jörgen Samuelsson, Marek Leśko, Dennis Åsberg, Richard J. Lewis, Magnus Klarqvist, Tomas Leek
Publikováno v:
Journal of Chromatography A. 1496:80-91
The adsorption mechanism for three peptides was studied under overloaded conditions through adsorption isotherm measurements in the presence of an ion-pairing reagent, trifluoroacetic acid (TFA), on an end-capped C18-bonded stationary phase. The over
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fca8b6f2aa382fb4cb3e38cd792d9c0a
https://doi.org/10.1016/j.chroma.2017.03.041
https://doi.org/10.1016/j.chroma.2017.03.041
Autor:
Madeleine Hill, Philippe Hubert, Katerina Plachka, Abhijit Tarafder, Adrien Raimbault, Benjamin Wuyts, Manish Grangrade, Niranjan Desphande, Andrew J. Aubin, Fabien Mauge, Vincent Desfontaine, Lucie Nováková, Erik L. Regalado, Mengling Wong, Sophie Bertin, Alexandre Grand-Guillaume Perrenoud, Julien Lefevre, Estelle Corbel, Caroline West, Elise Lemasson, Santosh Sadaphule, Dorina Kotoni, Brandon M. Jocher, Adrian Clarke, Marion Iguiniz, Eric Lesellier, Tomas Leek, Davy Guillarme, Debby Mangelings, Yvan Vander Heyden, Loic Villemet, Ravi Yadav, Nicolas Roques, Sabine Heinisch, Philippe Hennig, Luca Gioacchino Losacco, Isabelle François, Maxime Cazes, Nathalie Da Costa, Claudio Brunelli, Jean-Luc Veuthey, William Farrell, Kelly Zhang, Roland Djang’eing’a Marini, Christophe Desvignes, Shankar Shringare, Charlene Galea, Michael J. Gray, Amandine Dispas, Sandesh Rane, Lulu Dai, Morgan Sarrut
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis
Journal of Pharmaceutical and Biomedical Analysis, Elsevier, 2018, 161, pp.414-424. ⟨10.1016/j.jpba.2018.08.042⟩
Journal of Pharmaceutical and Biomedical Analysis, 2018, 161, pp.414-424. ⟨10.1016/j.jpba.2018.08.042⟩
Journal of Pharmaceutical and Biomedical Analysis, Vol. 161 (2018) pp. 414-424
Journal of Pharmaceutical and Biomedical Analysis, Elsevier, 2018, 161, pp.414-424. ⟨10.1016/j.jpba.2018.08.042⟩
Journal of Pharmaceutical and Biomedical Analysis, 2018, 161, pp.414-424. ⟨10.1016/j.jpba.2018.08.042⟩
Journal of Pharmaceutical and Biomedical Analysis, Vol. 161 (2018) pp. 414-424
International audience; Supercritical Fluid Chromatography (SFC) has known a strong regain of interest for the last 10 years, especially in the field of pharmaceutical analysis. Besides the development and validation of the SFC method in one individu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25627595ee086c92325373650cf6e126
https://hal.archives-ouvertes.fr/hal-01911400
https://hal.archives-ouvertes.fr/hal-01911400
Autor:
Martin, Enmark, Emelie, Glenne, Marek, Leśko, Annika, Langborg Weinmann, Tomas, Leek, Krzysztof, Kaczmarski, Magnus, Klarqvist, Jörgen, Samuelsson, Torgny, Fornstedt
Publikováno v:
Journal of chromatography. A. 1568
We investigated and compared the robustness of supercritical fluid chromatography (SFC) separations of the peptide gramicidin, using either isocratic or gradient elution. This was done using design of experiments in a design space of co-solvent fract
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3aee3002a3989b54ce0336d47a319fa9
https://pubmed.ncbi.nlm.nih.gov/30072233
https://pubmed.ncbi.nlm.nih.gov/30072233
Autor:
Marek Leśko, Krzysztof Kaczmarski, Tomas Leek, Jörgen Samuelsson, Torgny Fornstedt, Dennis Åsberg
Publikováno v:
Chromatographia
In electrostatic repulsive interaction chromatography, using a charged surface hybrid sorbent carrying positive charges can improve the peak shape of peptides in reversed-phase liquid chromatography (RP-LC), especially in overloaded conditions, compa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::511d5eb13c8448e982e65773e1ee5f45
http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-65567
http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-65567
Publikováno v:
Journal of Chromatography A, 1351, 70-81. Elsevier
Mucin glycoproteins belong to a class of high molecular weight, heavy glycosylated, proteins that together with water, salts and lipids constitute mucous secretions. Particular disease states (e.g. obstructive chronic bronchitis and ovarian tumor) ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9f3f442112d22a99fbdda25e3ba4bc8
https://dare.uva.nl/personal/pure/en/publications/mucinbased-stationary-phases-as-tool-for-the-characterization-of-drugmucus-interaction(11ffe38e-5e14-4f24-91d7-d2485f02bcdf).html
https://dare.uva.nl/personal/pure/en/publications/mucinbased-stationary-phases-as-tool-for-the-characterization-of-drugmucus-interaction(11ffe38e-5e14-4f24-91d7-d2485f02bcdf).html
Publikováno v:
Journal of chromatography. A. 1317
In the present contribution a novel Ugi multicomponent reaction (MCR) was used to generate zwitterionic chromatographic selectors with capability for application in mixed-mode chromatography featuring complementary selectivities in reversed-phase (RP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be46f789c2be34ca18456cb4da46028b
https://pubmed.ncbi.nlm.nih.gov/23932032
https://pubmed.ncbi.nlm.nih.gov/23932032
Publikováno v:
Therapeutic drug monitoring. 20(3)
An improved and validated method is presented for the determination of proguanil, cycloguanil, and 4-chlorophenylbiguanide in plasma, whole blood, and urine using solid-phase extraction (SPE) technique and reversed-phase high-performance liquid chrom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9070b2e64f9aaeb3b5bee9b421e5e798
https://pubmed.ncbi.nlm.nih.gov/9631931
https://pubmed.ncbi.nlm.nih.gov/9631931