Zobrazeno 1 - 10
of 196
pro vyhledávání: '"Tomas Kirchhausen"'
Autor:
Ian A Swinburne, Kishore R Mosaliganti, Srigokul Upadhyayula, Tsung-Li Liu, David G C Hildebrand, Tony Y -C Tsai, Anzhi Chen, Ebaa Al-Obeidi, Anna K Fass, Samir Malhotra, Florian Engert, Jeff W Lichtman, Tomas Kirchhausen, Eric Betzig, Sean G Megason
Publikováno v:
eLife, Vol 7 (2018)
The inner ear is a fluid-filled closed-epithelial structure whose function requires maintenance of an internal hydrostatic pressure and fluid composition. The endolymphatic sac (ES) is a dead-end epithelial tube connected to the inner ear whose funct
Externí odkaz:
https://doaj.org/article/9605396941f44e5497b36a7a18e10d89
Autor:
Manuel Alonso Y Adell, Simona M Migliano, Srigokul Upadhyayula, Yury S Bykov, Simon Sprenger, Mehrshad Pakdel, Georg F Vogel, Gloria Jih, Wesley Skillern, Reza Behrouzi, Markus Babst, Oliver Schmidt, Michael W Hess, John AG Briggs, Tomas Kirchhausen, David Teis
Publikováno v:
eLife, Vol 6 (2017)
The ESCRT machinery mediates reverse membrane scission. By quantitative fluorescence lattice light-sheet microscopy, we have shown that ESCRT-III subunits polymerize rapidly on yeast endosomes, together with the recruitment of at least two Vps4 hexam
Externí odkaz:
https://doaj.org/article/bfacb53d082646339785a5fcad761fe0
Publikováno v:
Cell Reports, Vol 4, Iss 6, Pp 1144-1155 (2013)
Removal of introns from pre-messenger RNAs (pre-mRNAs) via splicing provides a versatile means of genetic regulation that is often disrupted in human diseases. To decipher how splicing occurs in real time, we directly examined with single-molecule se
Externí odkaz:
https://doaj.org/article/2e01e653e8174c5d8dc35bae870f521c
Autor:
Huajin Wang, Michel Becuwe, Benjamin E Housden, Chandramohan Chitraju, Ashley J Porras, Morven M Graham, Xinran N Liu, Abdou Rachid Thiam, David B Savage, Anil K Agarwal, Abhimanyu Garg, Maria-Jesus Olarte, Qingqing Lin, Florian Fröhlich, Hans Kristian Hannibal-Bach, Srigokul Upadhyayula, Norbert Perrimon, Tomas Kirchhausen, Christer S Ejsing, Tobias C Walther, Robert V Farese Jr
Publikováno v:
eLife, Vol 5 (2016)
How proteins control the biogenesis of cellular lipid droplets (LDs) is poorly understood. Using Drosophila and human cells, we show here that seipin, an ER protein implicated in LD biology, mediates a discrete step in LD formation—the conversion o
Externí odkaz:
https://doaj.org/article/883e847c4c0c4cafacec7a73841c1ae8
Autor:
Thomas J.F. Nieland, Angeliki Chroni, Michael L. Fitzgerald, Zoltan Maliga, Vassilis I. Zannis, Tomas Kirchhausen, Monty Krieger
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 7, Pp 1256-1265 (2004)
Scavenger receptor class B type I (SR-BI) and ABCA1 are structurally dissimilar cell surface proteins that play key roles in HDL metabolism. SR-BI is a receptor that binds HDL with high affinity and mediates both the selective lipid uptake of cholest
Externí odkaz:
https://doaj.org/article/fc2eb6178bc1435f8108477e319ae8f1
Autor:
Aliaa H Abdelhakim, Eric N Salgado, Xiaofeng Fu, Mithun Pasham, Daniela Nicastro, Tomas Kirchhausen, Stephen C Harrison
Publikováno v:
PLoS Pathogens, Vol 10, Iss 9, p e1004355 (2014)
Cell entry by non-enveloped viruses requires translocation into the cytosol of a macromolecular complex--for double-strand RNA viruses, a complete subviral particle. We have used live-cell fluorescence imaging to follow rotavirus entry and penetratio
Externí odkaz:
https://doaj.org/article/2201333dcbeb487fb31303dcbc03f40d
Publikováno v:
mBio, Vol 3, Iss 1 (2012)
ABSTRACT Drastic reorganization of the nucleus is a hallmark of herpesvirus replication. This reorganization includes the formation of viral replication compartments, the subnuclear structures in which the viral DNA genome is replicated. The architec
Externí odkaz:
https://doaj.org/article/35812a898e5b4d2ea29f68583ca8aa9c
Publikováno v:
PLoS Pathogens, Vol 6, Iss 9, p e1001127 (2010)
Microbial pathogens exploit the clathrin endocytic machinery to enter host cells. Vesicular stomatitis virus (VSV), an enveloped virus with bullet-shaped virions that measure 70 x 200 nm, enters cells by clathrin-dependent endocytosis. We showed prev
Externí odkaz:
https://doaj.org/article/48fd6ca6b2ce4ecea2b5f12f7bd8c5f8
Autor:
Audrun Utskarpen, Ramiro Massol, Bo van Deurs, Silje Ugland Lauvrak, Tomas Kirchhausen, Kirsten Sandvig
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e10944 (2010)
Clathrin-dependent endocytosis is a main entry mechanism for the glycolipid-binding Shiga toxin (Stx), although clathrin-independent pathways are also involved. Binding of Stx to its receptor Gb3 not only is essential for Stx retrograde transport to
Externí odkaz:
https://doaj.org/article/55f11ac3b5fb41bf94dc9cf0ef2b096c
Publikováno v:
PLoS ONE, Vol 5, Iss 5, p e10597 (2010)
The notion that AP-2 clathrin adaptor is an essential component of an endocytic clathrin coat appears to conflict with recent observations that substantial AP-2 depletion, using RNA interference with synthesis of AP-2 subunits, fails to block uptake
Externí odkaz:
https://doaj.org/article/1319fb8bdac44673962c2ea47309c70d