Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Tomas Castro-Dopico"'
Autor:
Alexandra M. Riding, Kevin W. Loudon, Andrew Guo, John R. Ferdinand, Laurence S.C. Lok, Nathan Richoz, Andrew Stewart, Tomas Castro-Dopico, Zewen Kelvin Tuong, Remi Fiancette, Georgina S. Bowyer, Aaron Fleming, Eleanor S. Gillman, Ondrej Suchanek, Krishnaa T. Mahbubani, Kourosh Saeb-Parsy, David Withers, Gordan Dougan, Simon Clare, Menna R. Clatworthy
Publikováno v:
iScience, Vol 25, Iss 7, Pp 104660- (2022)
Summary: Bladder infection affects a hundred million people annually, but our understanding of bladder immunity is incomplete. We found type 17 immune response genes among the most up-regulated networks in mouse bladder following uropathogenic Escher
Externí odkaz:
https://doaj.org/article/7b71a1da869042258748c9da3a1ab75a
Publikováno v:
Gut Microbes, Vol 12, Iss 1 (2020)
Immunoglobulins (Igs) form a cornerstone of mucosal immunity. In the gastrointestinal tract, secretory IgA and IgM bind to commensal microorganisms within the intestinal lumen to prevent them from breaching the intestinal epithelium – a process kno
Externí odkaz:
https://doaj.org/article/d4d2647e41614b289459fe18dc691a73
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Fcγ receptors (FcγR) are cell surface glycoproteins that mediate cellular effector functions of immunoglobulin G (IgG) antibodies. Genetic variation in FcγR genes can influence susceptibility to a variety of antibody-mediated autoimmune and inflam
Externí odkaz:
https://doaj.org/article/c35de1e722e446f9aea2532436eeb1bd
Autor:
Mathieu Uzzan, Jerome C. Martin, Luka Mesin, Alexandra E. Livanos, Tomas Castro-Dopico, Ruiqi Huang, Francesca Petralia, Giuliana Magri, Shashi Kumar, Qing Zhao, Adam K. Rosenstein, Minami Tokuyama, Keshav Sharma, Ryan Ungaro, Roman Kosoy, Divya Jha, Jeremy Fischer, Harpriya Singh, Mary E. Keir, Nandhini Ramamoorthi, William E. O’Gorman, Benjamin L. Cohen, Adeeb Rahman, Francesca Cossarini, Akihiro Seki, Louise Leyre, Sonia Tejedor Vaquero, Sakteesh Gurunathan, Emilie K. Grasset, Bojan Losic, Marla Dubinsky, Alexander J. Greenstein, Zoe Gottlieb, Peter Legnani, James George, Haritz Irizar, Aleksandar Stojmirovic, Carrie Brodmerkel, Andrew Kasarkis, Bruce E. Sands, Glaucia Furtado, Sergio A. Lira, Zewen K. Tuong, Huaibin M. Ko, Andrea Cerutti, Charles O. Elson, Menna R. Clatworthy, Miriam Merad, Mayte Suárez-Fariñas, Carmen Argmann, Jason A. Hackney, Gabriel D. Victora, Gwendalyn J. Randolph, Ephraim Kenigsberg, Jean Frederic Colombel, Saurabh Mehandru
Publikováno v:
Nat Med
B cells, which are critical for intestinal homeostasis, remain understudied in ulcerative colitis (UC). In this study, we recruited three cohorts of patients with UC (primary cohort, n = 145; validation cohort 1, n = 664; and validation cohort 2, n =
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::174661bdc81a07d2cf2f022bc6ddd914
https://doi.org/10.1038/s41591-022-01680-y
https://doi.org/10.1038/s41591-022-01680-y
Autor:
Kathleen R Bashant, Rebeccah J. Mathews, Gemma D Banham, Mariana J. Kaplan, Arthur Kaser, Nathan Richoz, Zewen K. Tuong, Zaeem Cader, Chenzhi Jing, Randall S. Johnson, Kevin W. Loudon, Susan Fitzpatrick, Richard M. Siegel, Tomas Castro-Dopico, Michael P. Murphy, Menna R. Clatworthy, Laurence S C Lok, John R. Ferdinand
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance IgG antibodies are a key component of adaptive humoral immunity but can cause organ damage if they bind self-antigen, as occurs in the autoimmune disease systemic lupus erythematosus (SLE). Many of the proinflammatory effects of IgG are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da797ef058b0a2ee08439cc1d79df643
https://doi.org/10.1073/pnas.2000943117
https://doi.org/10.1073/pnas.2000943117
The gastrointestinal tract is colonized by trillions of commensal microorganisms that collectively form the microbiome and make essential contributions to organism homeostasis. The intestinal immune system must tolerate these beneficial commensals, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d8797a594dc5b7fd75c33ed59b7819a
https://www.repository.cam.ac.uk/handle/1810/333023
https://www.repository.cam.ac.uk/handle/1810/333023
Autor:
Alexandra M. Riding, Kevin W. Loudon, Andrew Guo, John R. Ferdinand, Laurence S.C. Lok, Nathan Richoz, Andrew Stewart, Tomas Castro-Dopico, Zewen Kelvin Tuong, Remi Fiancette, Georgina S. Bowyer, Aaron Fleming, Eleanor S. Gillman, Ondrej Suchanek, Krishnaa T. Mahbubani, Kourosh Saeb-Parsy, David Withers, Gordan Dougan, Simon Clare, Menna R. Clatworthy
Publikováno v:
iScience. 25(7)
Bladder infection affects a hundred million people annually, but our understanding of bladder immunity is incomplete. We found type 17 immune response genes among the most up-regulated networks in mouse bladder following uropathogenic Escherichia col
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::167c64314c353931f0539e1a58b86cba
https://pubmed.ncbi.nlm.nih.gov/35845169
https://pubmed.ncbi.nlm.nih.gov/35845169
Autor:
Christopher J. Ward, Sarah A. Hosgood, Tomas Castro-Dopico, Michael L. Nicholson, John R. Ferdinand, Thomas Moore, Ashley Ferro, Menna R. Clatworthy
Publikováno v:
American Journal of Transplantation
Funder: NIHR Cambridge Biomedical research Centre
Transplantation is the optimal treatment for most patients with end‐stage kidney disease but organ shortage is a major challenge. Normothermic machine perfusion (NMP) has been used to reconditi
Transplantation is the optimal treatment for most patients with end‐stage kidney disease but organ shortage is a major challenge. Normothermic machine perfusion (NMP) has been used to reconditi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de89de66a7814739038dca837925fed1
https://www.repository.cam.ac.uk/handle/1810/323411
https://www.repository.cam.ac.uk/handle/1810/323411
Autor:
Tomas Castro-Dopico, Chenzhi Jing, Simon Clare, Thomas W. Dennison, Katherine Harcourt, John R. Ferdinand, Menna R. Clatworthy, Arthur Kaser, Laurence S C Lok, Zaeem Cader, Aaron M. Fleming, Benjamin J. Stewart, Anaïs Portet, Rebeccah J. Mathews, Zewen K. Tuong
Publikováno v:
Cell Reports
Summary Macrophages play a central role in intestinal immunity, but inappropriate macrophage activation is associated with inflammatory bowel disease (IBD). Here, we identify granulocyte-macrophage colony stimulating factor (GM-CSF) as a critical reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e127ccdea0ccfdc34af5ad8e003b8226
http://europepmc.org/articles/PMC7351110
http://europepmc.org/articles/PMC7351110
Publikováno v:
Curr Opin Pharmacol
B cells are critical to immune homeostasis at mucosal surfaces including those of the gastrointestinal tract. B cell-related abnormalities, comprising of a lympho-plasmacytic infiltrate, as well as anti-microbial antibodies, are well reported in pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97a1f4f0c3ad99aa86d26c3ba7121857
https://pubmed.ncbi.nlm.nih.gov/33166872
https://pubmed.ncbi.nlm.nih.gov/33166872