Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Tomas Borgegard"'
Autor:
Kenneth Stockling, Johan Lundkvist, Johanna Wanngren, Susanne Rosqvist, Johan Lund, Samuel P.S. Svensson, Anna-Lena Berg, Anna Ridderstad-Wollberg, Fredrik Olsson, Lutgarde Serneels, Åsa Malmberg, Per I. Arvidsson, Bart De Strooper, Susanne Gustavsson, Hongmei Yan, Shaobo Jin, Urban Lendahl, Anders Juréus, Rebecka Klintenberg, Charlotte B. Nilsson, Santiago Parpal, Tomas Borgegard, Helena Karlström, Patrik Wollberg
γ-Secretase inhibition represents a major therapeutic strategy for lowering amyloid β (Aβ) peptide production in Alzheimer's disease (AD). Progress toward clinical use of γ-secretase inhibitors has, however, been hampered due to mechanism-based a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dc3d61009b088efcf33644856c3a50a
https://europepmc.org/articles/PMC6621836/
https://europepmc.org/articles/PMC6621836/
Autor:
Jan Ottervald, Santiago Parpal, Kia Strömberg, Johan Lundkvist, Tomas Borgegard, Johanna Wanngren, Susanne Rosqvist, Rebecka Klintenberg, Henrik Zetterberg, Jenny Blomqvist, Helena Karlström, Erik Portelius, Kaj Blennow, Anders Juréus
Publikováno v:
The Journal of biological chemistry. 287(39)
The γ-secretase complex is an appealing drug target when the therapeutic strategy is to alter amyloid-β peptide (Aβ) aggregation in Alzheimer disease. γ-Secretase is directly involved in Aβ formation and determines the pathogenic potential of A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2851c59fed8c9e7cfa369a9c1eaddba5
https://pubmed.ncbi.nlm.nih.gov/22851182
https://pubmed.ncbi.nlm.nih.gov/22851182
Autor:
Santiago Parpal, Fredrik Olsson, Alan Sabirsh, Didier Rotticci, Ann-Cathrin Radesäter, Håkan Eriksson, Anders Juréus, Tingsheng Li, Rebecka Klintenberg, Magnus Waldman, Tomas Borgegard, Johan Nord, Rajeshwar Singh, Susanne Rosqvist, Kim Paulsen, Hongmei Yan, Johan Lundkvist, Jonas S. Johansson, Anna Regner, David Malinowsky, Kia Strömberg
γ-Secretase-mediated cleavage of amyloid precursor protein (APP) results in the production of Alzheimer disease-related amyloid-β (Aβ) peptides. The Aβ42 peptide in particular plays a pivotal role in Alzheimer disease pathogenesis and represents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b2f34018c9aa6fa23d4fae0a804713c
https://europepmc.org/articles/PMC3320929/
https://europepmc.org/articles/PMC3320929/