Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Tomas Šinkūnas"'
Autor:
Tomas Šinkūnas
Publikováno v:
Problemos, Vol 102 (2022)
Today, scholars struggle to provide a coherent account of the unique, unitary structure of disgust as portrayed in Aurel Kolnai’s essay On Disgust. And even though Kolnai stressed that ambivalence was the main challenge in accounting for the essenc
Externí odkaz:
https://doaj.org/article/ba8290936f7d4d08b01eba15e2c07d63
Autor:
Tomas Šinkūnas
Publikováno v:
HORIZON / Fenomenologicheskie issledovanija/ STUDIEN ZUR PHÄNOMENOLOGIE / STUDIES IN PHENOMENOLOGY / ÉTUDES PHÉNOMÉNOLOGIQUES. 8:725-732
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::699152ab8a7c06c269a617ff9e34f689
https://doi.org/10.21638/2226-5260-2019-8-2-725-732
https://doi.org/10.21638/2226-5260-2019-8-2-725-732
Autor:
Pierre Aldag, Marius Rutkauskas, Julene Madariaga-Marcos, Inga Songailiene, Tomas Sinkunas, Felix Kemmerich, Dominik Kauert, Virginijus Siksnys, Ralf Seidel
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract CRISPR-Cas effector complexes enable the defense against foreign nucleic acids and have recently been exploited as molecular tools for precise genome editing at a target locus. To bind and cleave their target, the CRISPR-Cas effectors have t
Externí odkaz:
https://doaj.org/article/e871251abb314dc899785b43baed2dc2
Autor:
Tomas Šinkūnas
Publikováno v:
HORIZON / Fenomenologicheskie issledovanija/ STUDIEN ZUR PHÄNOMENOLOGIE / STUDIES IN PHENOMENOLOGY / ÉTUDES PHÉNOMÉNOLOGIQUES. 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::713c50cab70514849ca3ee04aa7a34e9
https://doi.org/10.21638/2226-5260-2017-6-2-226-249
https://doi.org/10.21638/2226-5260-2017-6-2-226-249
Autor:
Marius Rutkauskas, Inga Songailiene, Patrick Irmisch, Felix E. Kemmerich, Tomas Sinkunas, Virginijus Siksnys, Ralf Seidel
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Based on thorough single-molecule analysis of off-target binding by the CRISPR-Cas surveillance complex Cascade, a mechanism-based model is presented that quantitatively describes the recognition dynamics of mutated targets by this protein.
Externí odkaz:
https://doaj.org/article/c899fa03b0a74176bb9813625f974959
Autor:
Egle Kupcinskaite, Marijonas Tutkus, Aurimas Kopūstas, Simonas Ašmontas, Marija Jankunec, Mindaugas Zaremba, Giedre Tamulaitiene, Tomas Sinkunas
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract CRISPR-Cas systems are prokaryotic adaptive immune systems that protect against phages and other invading nucleic acids. The evolutionary arms race between prokaryotes and phages gave rise to phage anti-CRISPR (Acr) proteins that act as a co
Externí odkaz:
https://doaj.org/article/ae7f2c66b11e44f39960982c86ff9f9e
Autor:
Donata Tuminauskaite, Danguole Norkunaite, Marija Fiodorovaite, Sarunas Tumas, Inga Songailiene, Giedre Tamulaitiene, Tomas Sinkunas
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-16 (2020)
Abstract Background CRISPR-Cas systems, which provide adaptive immunity against foreign nucleic acids in prokaryotes, can serve as useful molecular tools for multiple applications in genome engineering. Diverse CRISPR-Cas systems originating from dis
Externí odkaz:
https://doaj.org/article/c2df8a59538840ca8376f4ace2540e43
Autor:
Inga Songailiene, Marius Rutkauskas, Tomas Sinkunas, Elena Manakova, Sabine Wittig, Carla Schmidt, Virginijus Siksnys, Ralf Seidel
Publikováno v:
Cell Reports, Vol 28, Iss 12, Pp 3157-3166.e4 (2019)
Summary: The multi-subunit type I CRISPR-Cas surveillance complex Cascade uses its crRNA to recognize dsDNA targets. Recognition involves DNA unwinding and base-pairing between the crRNA spacer region and a complementary DNA strand, resulting in form
Externí odkaz:
https://doaj.org/article/a545ce10365146db92a8077000d6b635
Autor:
Marius Rutkauskas, Tomas Sinkunas, Inga Songailiene, Maria S. Tikhomirova, Virginijus Siksnys, Ralf Seidel
Publikováno v:
Cell Reports, Vol 10, Iss 9, Pp 1534-1543 (2015)
CRISPR-Cas systems provide bacteria and archaea with adaptive immunity against foreign nucleic acids. In type I CRISPR-Cas systems, invading DNA is detected by a large ribonucleoprotein surveillance complex called Cascade. The crRNA component of Casc
Externí odkaz:
https://doaj.org/article/15d9fabe7cfb4cd3b841283dbd20918f