Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Tomas, Smolek"'
Autor:
Tomas Smolek, Zuzana Vince-Kazmerova, Jozef Hanes, Eva Stevens, Viktor Palus, Ivo Hajek, Stanislav Katina, Petr Novak, Norbert Zilka
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract The cerebral biomarkers, neurofilament light chain (NfL), amyloid-β, tau, and neuron specific enolase (NSE) reflect a wide spectrum of neurological damage in the brain and spinal cord. With this study, we aimed to assess whether these bioma
Externí odkaz:
https://doaj.org/article/ed6163cbb55c47ff9f9ffb7abccacde6
TLR4-mediated chronic neuroinflammation has no effect on tangle pathology in a tauopathy mouse model
Autor:
Neha Basheer, Muhammad Khalid Muhammadi, Carlos Leandro Freites, Martin Avila, Miraj Ud Din Momand, Natalia Hryntsova, Tomas Smolek, Stanislav Katina, Norbert Zilka
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
IntroductionAlzheimer’s disease (AD) is marked by the accumulation of fibrillary aggregates composed of pathological tau protein. Although neuroinflammation is frequently observed in conjunction with tau pathology, current preclinical evidence does
Externí odkaz:
https://doaj.org/article/98d81d157ec549a9bc79c77f0280727d
Autor:
Neha Basheer, Luc Buee, Jean-Pierre Brion, Tomas Smolek, Muhammad Khalid Muhammadi, Jozef Hritz, Tomas Hromadka, Ilse Dewachter, Susanne Wegmann, Isabelle Landrieu, Petr Novak, Amritpal Mudher, Norbert Zilka
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-31 (2024)
Abstract The transcellular propagation of the aberrantly modified protein tau along the functional brain network is a key hallmark of Alzheimer's disease and related tauopathies. Inoculation-based tau propagation models can recapitulate the stereotyp
Externí odkaz:
https://doaj.org/article/0547cc546b564dafa9cf1056d3b05ad1
Autor:
Veronika Mate, Tomas Smolek, Zuzana Vince Kazmerova, Santosh Jadhav, Veronika Brezovakova, Bernadeta Jurkanin, Ivana Uhrinova, Neha Basheer, Norbert Zilka, Stanislav Katina, Petr Novak
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
IntroductionThe typical symptoms of Alzheimer’s disease (AD) are cognitive impairment, disrupted spatial orientation, behavioral and psychiatric abnormalities, and later motor deficits. Neuropathologically, AD is characterized by deposits of pathol
Externí odkaz:
https://doaj.org/article/b98f4fa7034c4744a1570de7efa83814
Autor:
Zuzana Vikartovska, Jana Farbakova, Tomas Smolek, Jozef Hanes, Norbert Zilka, Lubica Hornakova, Filip Humenik, Marcela Maloveska, Nikola Hudakova, Dasa Cizkova
Publikováno v:
Frontiers in Veterinary Science, Vol 7 (2021)
Canine cognitive dysfunction syndrome (CCDS) is a progressive neurodegenerative disorder in senior dogs that is mainly associated with decreased ability to learn and respond to stimuli. It is commonly under-diagnosed because behavioral changes are of
Externí odkaz:
https://doaj.org/article/abe636c1ea904b7087fabd2a6abc010a
Autor:
Tomas Smolek, Veronika Cubinkova, Veronika Brezovakova, Bernadeta Valachova, Peter Szalay, Norbert Zilka, Santosh Jadhav
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
Externí odkaz:
https://doaj.org/article/d399ee436a0f4d0ab1c545d20814214a
Autor:
Petr Novak, Reinhold Schmidt, Eva Kontsekova, Branislav Kovacech, Tomas Smolek, Stanislav Katina, Lubica Fialova, Michal Prcina, Vojtech Parrak, Peter Dal-Bianco, Martin Brunner, Wolfgang Staffen, Michael Rainer, Matej Ondrus, Stefan Ropele, Miroslav Smisek, Roman Sivak, Norbert Zilka, Bengt Winblad, Michal Novak
Publikováno v:
Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-16 (2018)
Abstract Background Neurofibrillary pathology composed of tau protein is closely correlated with severity and phenotype of cognitive impairment in patients with Alzheimer’s disease and non-Alzheimer’s tauopathies. Targeting pathological tau prote
Externí odkaz:
https://doaj.org/article/0a507430e9e248e6b42f67da7fb4aa06
Autor:
Tomas Smolek, Veronika Cubinkova, Veronika Brezovakova, Bernadeta Valachova, Peter Szalay, Norbert Zilka, Santosh Jadhav
Publikováno v:
Frontiers in Aging Neuroscience, Vol 11 (2019)
Alzheimer’s disease (AD), the most common tauopathy, is an age-dependent, progressive neurodegenerative disease. Epidemiological studies implicate the role of genetic background in the onset and progression of AD. Despite mutations in familial AD,
Externí odkaz:
https://doaj.org/article/b20010c9f4f44b43a9000c599811f726
Autor:
Martin, Cente, Tomas, Smolek, Stefan, Zorad, Lubica, Fialova, Natalia, Paulenka Ivanovova, Katarina, Krskova, Lucia, Balazova, Rostislav, Skrabana, Peter, Filipcik
Publikováno v:
General physiology and biophysics. 40:577-584
Neurodegeneration is associated with hypertension and disturbance in fat metabolism. The complex interaction of neurodegenerative processes with both metabolic changes and blood pressure is still not fully elucidated. Here we demonstrate that the exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19ca71e95f3f6aff7fc34c90381a3f04
https://doi.org/10.4149/gpb_2021037
https://doi.org/10.4149/gpb_2021037
Autor:
Katarina Matyasova, Nikoleta Csicsatkova, Norbert Zilka, Santosh Jadhav, Tomas Smolek, Lucie Kawecka, Martin Cente, Veronika Mate, Veronika Brezovakova, Peter Szalay
Publikováno v:
General physiology and biophysics. 40:541-549
Spreading of tau pathology to anatomical distinct regions in Alzheimer's disease (AD) is associated with progression of the disease. Studies in recent decade have strived to understand the processes involved in this characteristic spread. We recently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3530d79744e4a71ea2c7379b8c96f41
https://doi.org/10.4149/gpb_2021022
https://doi.org/10.4149/gpb_2021022