Zobrazeno 1 - 10
of 770
pro vyhledávání: '"Tomas, Olsson"'
Autor:
Majid Pahlevan Kakhki, Antonino Giordano, Chiara Starvaggi Cucuzza, Tejaswi Venkata S. Badam, Samudyata Samudyata, Marianne Victoria Lemée, Pernilla Stridh, Asimenia Gkogka, Klementy Shchetynsky, Adil Harroud, Alexandra Gyllenberg, Yun Liu, Sanjaykumar Boddul, Tojo James, Melissa Sorosina, Massimo Filippi, Federica Esposito, Fredrik Wermeling, Mika Gustafsson, Patrizia Casaccia, Jan Hillert, Tomas Olsson, Ingrid Kockum, Carl M. Sellgren, Christelle Golzio, Lara Kular, Maja Jagodic
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Multiple Sclerosis (MS) is a heterogeneous inflammatory and neurodegenerative disease with an unpredictable course towards progressive disability. Treating progressive MS is challenging due to limited insights into the underlying mechanisms.
Externí odkaz:
https://doaj.org/article/335891136a424c99812fda12c3ca1d91
Autor:
Zoe Marti, Josefine Ruder, Olivia G. Thomas, Mattias Bronge, Lorenzo De La Parra Soto, Hans Grönlund, Tomas Olsson, Roland Martin
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Multiple sclerosis (MS) is a prototypical autoimmune disease of the central nervous system (CNS). In addition to CD4+ T cells, memory B cells are now recognized as a critical cell type in the disease. This is underlined by the fact that the best-char
Externí odkaz:
https://doaj.org/article/dbc27b7318a14b8ba0dd9eeae0ba5490
Autor:
Rasmus Berglund, Yufei Cheng, Eliane Piket, Milena Z. Adzemovic, Manuel Zeitelhofer, Tomas Olsson, Andre Ortlieb Guerreiro-Cacais, Maja Jagodic
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Microglia harness an unutilized health-promoting potential in age-related neurodegenerative and neuroinflammatory diseases, conditions like progressive multiple sclerosis (MS). Our research unveils an microglia population emerging in the cor
Externí odkaz:
https://doaj.org/article/b61d9e7702d14043bf1b0b3ca392caef
Autor:
Lenka Novakova, Anna Karin Hedström, Markus Axelsson, Anne Frandsen Brandt, Lars Alfredsson, Tomas Olsson, Jan Lycke
Publikováno v:
Brain and Behavior, Vol 14, Iss 3, Pp n/a-n/a (2024)
Abstract Background A significant proportion of individuals with suspicious onset of multiple sclerosis (MS) does not fulfill the diagnostic criteria. Although some receive other diagnoses, many remain undiagnosed and lack healthcare follow‐up. Thi
Externí odkaz:
https://doaj.org/article/fc59ed666d324f91830d1944a59b9bee
Autor:
Mark S. Freedman, Sharmilee Gnanapavan, Ronald A. Booth, Peter A. Calabresi, Michael Khalil, Jens Kuhle, Jan Lycke, Tomas Olsson
Publikováno v:
EBioMedicine, Vol 101, Iss , Pp 104970- (2024)
Summary: Neurofilament light chain (NfL) is a long-awaited blood biomarker that can provide clinically useful information about prognosis and therapeutic efficacy in multiple sclerosis (MS). There is now substantial evidence for this biomarker to be
Externí odkaz:
https://doaj.org/article/4e3c083cc88e45e594ebc2a3e2e3dc56
Autor:
Julia Åkesson, Sara Hojjati, Sandra Hellberg, Johanna Raffetseder, Mohsen Khademi, Robert Rynkowski, Ingrid Kockum, Claudio Altafini, Zelmina Lubovac-Pilav, Johan Mellergård, Maria C. Jenmalm, Fredrik Piehl, Tomas Olsson, Jan Ernerudh, Mika Gustafsson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Sensitive and reliable protein biomarkers are needed to predict disease trajectory and personalize treatment strategies for multiple sclerosis (MS). Here, we use the highly sensitive proximity-extension assay combined with next-generation se
Externí odkaz:
https://doaj.org/article/fca5c6e467d64332997f913572d4f0f4
Autor:
Asmundur Oddsson, Patrick Sulem, Gardar Sveinbjornsson, Gudny A. Arnadottir, Valgerdur Steinthorsdottir, Gisli H. Halldorsson, Bjarni A. Atlason, Gudjon R. Oskarsson, Hannes Helgason, Henriette Svarre Nielsen, David Westergaard, Juha M. Karjalainen, Hildigunnur Katrinardottir, Run Fridriksdottir, Brynjar O. Jensson, Vinicius Tragante, Egil Ferkingstad, Hakon Jonsson, Sigurjon A. Gudjonsson, Doruk Beyter, Kristjan H. S. Moore, Helga B. Thordardottir, Snaedis Kristmundsdottir, Olafur A. Stefansson, Solbritt Rantapää-Dahlqvist, Ida Elken Sonderby, Maria Didriksen, Pernilla Stridh, Jan Haavik, Laufey Tryggvadottir, Oleksandr Frei, G. Bragi Walters, Ingrid Kockum, Henrik Hjalgrim, Thorunn A. Olafsdottir, Geir Selbaek, Mette Nyegaard, Christian Erikstrup, Thorsten Brodersen, Saedis Saevarsdottir, Tomas Olsson, Kaspar Rene Nielsen, Asgeir Haraldsson, Mie Topholm Bruun, Thomas Folkmann Hansen, DBDS Genomic Consortium, Thora Steingrimsdottir, Rikke Louise Jacobsen, Rolv T. Lie, Srdjan Djurovic, Lars Alfredsson, Aitzkoa Lopez de Lapuente Portilla, Soren Brunak, Pall Melsted, Bjarni V. Halldorsson, Jona Saemundsdottir, Olafur Th. Magnusson, Leonid Padyukov, Karina Banasik, Thorunn Rafnar, Johan Askling, Lars Klareskog, Ole Birger Pedersen, Gisli Masson, Alexandra Havdahl, Bjorn Nilsson, Ole A. Andreassen, Mark Daly, Sisse Rye Ostrowski, Ingileif Jonsdottir, Hreinn Stefansson, Hilma Holm, Agnar Helgason, Unnur Thorsteinsdottir, Kari Stefansson, Daniel F. Gudbjartsson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Genotypes causing pregnancy loss and perinatal mortality are depleted among living individuals and are therefore difficult to find. To explore genetic causes of recessive lethality, we searched for sequence variants with deficit of homozygos
Externí odkaz:
https://doaj.org/article/a4fa595277a74ef2949c5d74d9c4032d
Autor:
Hanna M. Ollila, Eilon Sharon, Ling Lin, Nasa Sinnott-Armstrong, Aditya Ambati, Selina M. Yogeshwar, Ryan P. Hillary, Otto Jolanki, Juliette Faraco, Mali Einen, Guo Luo, Jing Zhang, Fang Han, Han Yan, Xiao Song Dong, Jing Li, Jun Zhang, Seung-Chul Hong, Tae Won Kim, Yves Dauvilliers, Lucie Barateau, Gert Jan Lammers, Rolf Fronczek, Geert Mayer, Joan Santamaria, Isabelle Arnulf, Stine Knudsen-Heier, May Kristin Lyamouri Bredahl, Per Medbøe Thorsby, Giuseppe Plazzi, Fabio Pizza, Monica Moresco, Catherine Crowe, Stephen K. Van den Eeden, Michel Lecendreux, Patrice Bourgin, Takashi Kanbayashi, Francisco J. Martínez-Orozco, Rosa Peraita-Adrados, Antonio Benetó, Jacques Montplaisir, Alex Desautels, Yu-Shu Huang, FinnGen, Poul Jennum, Sona Nevsimalova, David Kemlink, Alex Iranzo, Sebastiaan Overeem, Aleksandra Wierzbicka, Peter Geisler, Karel Sonka, Makoto Honda, Birgit Högl, Ambra Stefani, Fernando Morgadinho Coelho, Vilma Mantovani, Eva Feketeova, Mia Wadelius, Niclas Eriksson, Hans Smedje, Pär Hallberg, Per Egil Hesla, David Rye, Zerrin Pelin, Luigi Ferini-Strambi, Claudio L. Bassetti, Johannes Mathis, Ramin Khatami, Adi Aran, Sheela Nampoothiri, Tomas Olsson, Ingrid Kockum, Markku Partinen, Markus Perola, Birgitte R. Kornum, Sina Rueger, Juliane Winkelmann, Taku Miyagawa, Hiromi Toyoda, Seik-Soon Khor, Mihoko Shimada, Katsushi Tokunaga, Manuel Rivas, Jonathan K. Pritchard, Neil Risch, Zoltan Kutalik, Ruth O’Hara, Joachim Hallmayer, Chun Jimmie Ye, Emmanuel J. Mignot
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Narcolepsy type 1 (NT1) is caused by a loss of hypocretin/orexin transmission. Risk factors include pandemic 2009 H1N1 influenza A infection and immunization with Pandemrix®. Here, we dissect disease mechanisms and interactions with environ
Externí odkaz:
https://doaj.org/article/5ce5735744474cff8886bce42fe536b9
Autor:
Olivia G. Thomas, Tomas Olsson
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
T cells have an essential role in adaptive immunity against pathogens and cancer, but failure of thymic tolerance mechanisms can instead lead to escape of T cells with the ability to attack host tissues. Multiple sclerosis (MS) occurs when structures
Externí odkaz:
https://doaj.org/article/a4fa63eef8cb4ebc9dab5aac5702b56f
Autor:
Ivan Kmezic, Rasmus Gustafsson, Katharina Fink, Anders Svenningsson, Kristin Samuelsson, Caroline Ingre, Tomas Olsson, Magnus Hansson, Ingrid Kockum, Milena Z. Adzemovic, Rayomand Press
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundBiomarkers for diagnosis of inflammatory neuropathies, assessment of prognosis, and treatment response are lacking.MethodsCSF and EDTA plasma from patients with Guillain-Barré syndrome (GBS), chronic inflammatory demyelinating polyneuropat
Externí odkaz:
https://doaj.org/article/16a4d9f5634040e7bbcc96cfc6c9796a