The α-synuclein PET tracer [18F] ACI-12589 distinguishes multiple system atrophy from other neurodegenerative diseases

Autor: Ruben Smith, Francesca Capotosti, Martin Schain, Tomas Ohlsson, Efthymia Vokali, Jerome Molette, Tanja Touilloux, Valerie Hliva, Ioannis K. Dimitrakopoulos, Andreas Puschmann, Jonas Jögi, Per Svenningsson, Mattias Andréasson, Christine Sandiego, David S. Russell, Patricia Miranda-Azpiazu, Christer Halldin, Erik Stomrud, Sara Hall, Klas Bratteby, Elina Tampio L’Estrade, Ruth Luthi-Carter, Andrea Pfeifer, Marie Kosco-Vilbois, Johannes Streffer, Oskar Hansson

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)

Abstract A positron emission tomography (PET) tracer detecting α-synuclein pathology will improve the diagnosis, and ultimately the treatment of α-synuclein-related diseases. Here we show that the PET ligand, [18F]ACI-12589, displays good in vitro

Externí odkaz: https://doaj.org/article/8e2d2bdd4dfc4ecea2658cceed5ad9e8

A prospective phase II study of prostate-specific antigen-guided salvage radiotherapy and 68Ga-PSMA-PET for biochemical relapse after radical prostatectomy – The PROPER 1 trial

Autor: Adalsteinn Gunnlaugsson, Vilberg Johannesson, Elinore Wieslander, Eva Brun, Ulrika Bitzén, Olof Ståhl, Ola Bratt, Göran Ahlgren, Tomas Ohlsson, Elisabeth Kjellén, Per Nilsson

Publikováno v: Clinical and Translational Radiation Oncology, Vol 36, Iss , Pp 77-82 (2022)

Background and purpose: The treatment of biochemical recurrence (BCR) after prostatectomy is challenging as the site of the recurrence is often undetectable. Our aim was to test a personalised treatment concept for BCR based on PSA kinetics during sa

Externí odkaz: https://doaj.org/article/2e80e2d99b4a40bb8a27ed43eb167633

[18F]RO948 tau positron emission tomography in genetic and sporadic frontotemporal dementia syndromes

Autor: Alexander F. Santillo, Antoine Leuzy, Michael Honer, Maria Landqvist Waldö, Pontus Tideman, Luke Harper, Tomas Ohlsson, Svenja Moes, Lucia Giannini, Jonas Jögi, Colin Groot, Rik Ossenkoppele, Olof Strandberg, John van Swieten, Ruben Smith, Oskar Hansson

Publikováno v: Santillo, A F, Leuzy, A, Honer, M, Landqvist Waldö, M, Tideman, P, Harper, L, Ohlsson, T, Moes, S, Giannini, L, Jögi, J, Groot, C, Ossenkoppele, R, Strandberg, O, van Swieten, J, Smith, R & Hansson, O 2022, ' [18F]RO948 tau positron emission tomography in genetic and sporadic frontotemporal dementia syndromes ', European Journal of Nuclear Medicine and Molecular Imaging . https://doi.org/10.1007/s00259-022-06065-4
European Journal of Nuclear Medicine and Molecular Imaging. Springer Verlag
European Journal of Nuclear Medicine and Molecular Imaging, 50(5), 1371-1383. Springer-Verlag

Purpose To examine [18F]RO948 retention in FTD, sampling the underlying protein pathology heterogeneity. Methods A total of 61 individuals with FTD (n = 35), matched cases of AD (n = 13) and Aβ-negative cognitively unimpaired individuals (n = 13) un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3211583246f197264d679de81f03d860
http://www.scopus.com/inward/record.url?scp=85143887800&partnerID=8YFLogxK

Fully Automated GMP-Compliant Synthesis of [18F]FE-PE2I

Autor: Klas Bratteby, Charlotte Lund Denholt, Szabolcs Lehel, Ida Nymann Petersen, Jacob Madsen, Maria Erlandsson, Tomas Ohlsson, Matthias Manfred Herth, Nic Gillings

Publikováno v: Pharmaceuticals, Vol 14, Iss 7, p 601 (2021)

In the struggle to understand and accurately diagnose Parkinson′s disease, radiopharmaceuticals and medical imaging techniques have played a major role. By being able to image and quantify the dopamine transporter density, noninvasive diagnostic im

Externí odkaz: https://doaj.org/article/9970e4c34953481b89c3e280c1ae8e6c

Clinical Utility of Tau Positron Emission Tomography in the Diagnostic Workup of Patients With Cognitive Symptoms

Autor: Ruben Smith, Douglas Hägerström, Daria Pawlik, Gregory Klein, Jonas Jögi, Tomas Ohlsson, Erik Stomrud, Oskar Hansson

Publikováno v: JAMA Neurology.

ImportanceIt is important to determine the added clinical value for tau positron emission tomography (PET) in the diagnostic workup of patients with cognitive symptoms before widespread implementation in clinical practice.ObjectiveTo prospectively st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d01f585aca9e9f9511d78a3c52b87f93
https://doi.org/10.1001/jamaneurol.2023.1323