Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Tomas, Kanholm"'
1
Akademický článek
MMP-2 is a novel histone H3 N-terminal protease necessary for myogenic gene activation
Autor: Judd C. Rice, Benjamin H. Weekley, Tomas Kanholm, Zhihui Chen, Sunyoung Lee, Daniel J. Fernandez, Rachel Abrahamson, Alessandra Castaldi, Zea Borok, Brian D. Dynlacht, Woojin An
Publikováno v: Epigenetics & Chromatin, Vol 14, Iss 1, Pp 1-12 (2021)
Abstract Background Selective proteolysis of the histone H3 N-terminal tail (H3NT) is frequently observed during eukaryotic development, generating a cleaved histone H3 (H3cl) product within a small, but significant, portion of the genome. Although i
Externí odkaz: https://doaj.org/article/693bd8e673be46a79c89da26efca485f
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2
Akademický článek
Mitochondrial Enzymes of the Urea Cycle Cluster at the Inner Mitochondrial Membrane
Autor: Nantaporn Haskins, Shivaprasad Bhuvanendran, Claudio Anselmi, Anna Gams, Tomas Kanholm, Kristen M. Kocher, Jonathan LoTempio, Kylie I. Krohmaly, Danielle Sohai, Nathaniel Stearrett, Erin Bonner, Mendel Tuchman, Hiroki Morizono, Jyoti K. Jaiswal, Ljubica Caldovic
Publikováno v: Frontiers in Physiology, Vol 11 (2021)
Mitochondrial enzymes involved in energy transformation are organized into multiprotein complexes that channel the reaction intermediates for efficient ATP production. Three of the mammalian urea cycle enzymes: N-acetylglutamate synthase (NAGS), carb
Externí odkaz: https://doaj.org/article/d0513014ca26433bbf1cf3d4ad8f47b7
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7
Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a TP53-Dependent Manner
Autor: Tomas Kanholm, Melissa Hadley, Reiner Strick, Erin E. Grundy, Ting Wang, Pamela L. Strissel, Stephanie Gomez, Angela Yu, Uzma Rentia, Noor Diab, Michael J. Topper, Stephen B. Baylin, James I. McDonald, Xiaoyun Xing, Katherine B. Chiappinelli, Olivia Cox, Elisa Arthofer
Publikováno v: Cancer Research. 81:5176-5189
Epithelial ovarian carcinomas are particularly deadly due to intratumoral heterogeneity, resistance to standard-of-care therapies, and poor response to alternative treatments such as immunotherapy. Targeting the ovarian carcinoma epigenome with DNA m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ff92c7a02b46f22144ea83787cf5a312
https://doi.org/10.1158/0008-5472.can-20-4243
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8
Abstract A029: Transposable elements exhibit loss of DNA methylation and increases in transcription in a model of tumorigenesis
Autor: Tomas Kanholm, Uzma Rentia, Melissa Hadley Beaty, James I. McDonald, Wenbing Xie, Stephen B. Baylin, Kathleen H. Burns, Hari Easwaran, Katherine B. Chiappinelli
Publikováno v: Cancer Research. 82:A029-A029
Transposable elements (TEs), including LINEs, SINEs, and LTRs, are typically silenced by epigenetic mechanisms in differentiated healthy tissues. However, TE expression increases in a wide range of cancer types, likely due to global hypomethylation o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ea209a89c8e33e002c309f7b64d58288
https://doi.org/10.1158/1538-7445.cancepi22-a029
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9
Inhibiting DNA methylation and RNA editing upregulates immunogenic RNA to transform the tumor microenvironment and prolong survival in ovarian cancer
Autor: Stephanie Gomez, Olivia L Cox, Reddick R Walker, Uzma Rentia, Melissa Hadley, Elisa Arthofer, Noor Diab, Erin E Grundy, Tomas Kanholm, James I McDonald, Julie Kobyra, Erica Palmer, Satish Noonepalle, Alejandro Villagra, David Leitenberg, Catherine M Bollard, Yogen Saunthararajah, Katherine B Chiappinelli
Publikováno v: Journal for ImmunoTherapy of Cancer. 10:e004974
BackgroundNovel therapies are urgently needed for ovarian cancer (OC), the fifth deadliest cancer in women. Preclinical work has shown that DNA methyltransferase inhibitors (DNMTis) can reverse the immunosuppressive tumor microenvironment in OC. Inhi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4c8cc2a9f87f7c2a807e61e705834c0
https://doi.org/10.1136/jitc-2022-004974
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10
MMP-2 is a novel histone H3 N-terminal protease necessary for myogenic gene activation
Autor: Zhihui Chen, Zea Borok, Sun Young Lee, Benjamin H. Weekley, Judd C. Rice, Daniel J. Fernandez, Alessandra Castaldi, Rachel Abrahamson, Tomas Kanholm, Woojin An, Brian David Dynlacht
Publikováno v: Epigenetics & Chromatin
Epigenetics & Chromatin, Vol 14, Iss 1, Pp 1-12 (2021)
BackgroundSelective proteolysis of the histone H3 N-terminal tail (H3NT) is frequently observed during eukaryotic development, generating a cleaved histone H3 (H3cl) product within a small, but significant, portion of the genome. Although increasing
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::237b9ef3af1593eff33ba25a1a752b03
https://pubmed.ncbi.nlm.nih.gov/34001241
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