Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Tomas, Fiedler"'
Autor:
Charlotte Linke, Thomas Freitag, Christin Riess, Jana Vanessa Scheffler, Katharina del Moral, Nina Schoenwaelder, Tomas Fiedler, Adina Fiebig, Philipp Kaps, Daniel Dubinski, Björn Schneider, Wendy Bergmann, Carl Friedrich Classen, Claudia Maletzki
Publikováno v:
Cancer Cell International, Vol 23, Iss 1, Pp 1-18 (2023)
Abstract Background Arginine auxotrophy constitutes a shortcoming for ~ 30% of glioblastoma multiforme (GBM). Indeed, arginine-depleting therapy using arginine deiminase from Streptococcus pyogenes (SpyADI) has proven activity against GBM in preclini
Externí odkaz:
https://doaj.org/article/b688d5f6f21b43c69fa8ffaf7d1c4143
Autor:
Christin Riess, Katharina del Moral, Adina Fiebig, Philipp Kaps, Charlotte Linke, Burkhard Hinz, Anne Rupprecht, Marcus Frank, Tomas Fiedler, Dirk Koczan, Sascha Troschke-Meurer, Holger N. Lode, Nadja Engel, Thomas Freitag, Carl Friedrich Classen, Claudia Maletzki
Publikováno v:
Cell Death and Disease, Vol 13, Iss 6, Pp 1-14 (2022)
The complex effects of combined CDki/SPyADI application on arginine-auxotrophic glioblastoma multiforme cells. CDki/SPyADI combination therapy impairs cell proliferation, invasiveness, gene expression, induces mitochondrial impairment, and vacuole fo
Externí odkaz:
https://doaj.org/article/e4a237d57e9d4704bd9c0f69a431ba27
Autor:
Seyed Babak Loghmani, Eric Zitzow, Gene Ching Chiek Koh, Andreas Ulmer, Nadine Veith, Ruth Großeholz, Madlen Rossnagel, Maren Loesch, Ruedi Aebersold, Bernd Kreikemeyer, Tomas Fiedler, Ursula Kummer
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 2 (2022)
ABSTRACT Lactic acid bacteria (LAB) play a significant role in biotechnology, e.g., food industry and also in human health. Many LAB genera have developed a multidrug resistance in the past few years, causing a serious problem in controlling hospital
Externí odkaz:
https://doaj.org/article/cd1cdfcd982a4b8f9416cf476c305add
Autor:
Philip Eisenberg, Leon Albert, Jonathan Teuffel, Eric Zitzow, Claudia Michaelis, Jane Jarick, Clemens Sehlke, Lisa Große, Nicole Bader, Ariane Nunes-Alves, Bernd Kreikemeyer, Hermann Schindelin, Rebecca C. Wade, Tomas Fiedler
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
The strict human pathogen Streptococcus pyogenes causes infections of varying severity, ranging from self-limiting suppurative infections to life-threatening diseases like necrotizing fasciitis or streptococcal toxic shock syndrome. Here, we show tha
Externí odkaz:
https://doaj.org/article/06e0bdea46604a478a5c61687a0d7bac
Autor:
Christin Riess, Fatemeh Shokraie, Carl Friedrich Classen, Bernd Kreikemeyer, Tomas Fiedler, Christian Junghanss, Claudia Maletzki
Publikováno v:
Cellular Physiology and Biochemistry, Vol 51, Iss 2, Pp 854-870 (2018)
Arginine auxotrophy occurs in certain tumor types and is usually caused by the silencing of argininosuccinate synthetase 1 or arginine lyase genes. Such tumors are often associated with an intrinsic chemoresistance and thus a poor prognosis. Arginine
Externí odkaz:
https://doaj.org/article/07deca83d7ef459f8c6b4a08e663e55f
Autor:
Marcel-Lino Dangel, Johann-Christoph Dettmann, Steffi Haßelbarth, Martin Krogull, Miriam Schakat, Bernd Kreikemeyer, Tomas Fiedler
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0211074 (2019)
5'-nucleotidases are widespread among all domains of life. The enzymes hydrolyze phosphate residues from nucleotides and nucleotide derivatives. In some pathobiontic bacteria, 5'-nucleotidases contribute to immune evasion by dephosphorylating adenosi
Externí odkaz:
https://doaj.org/article/f4118bbd269b4144a5ffe1422e554f22
Autor:
Henrike Loeffler, Anika Jonitz-Heincke, Kirsten Peters, Brigitte Mueller-Hilke, Tomas Fiedler, Rainer Bader, Annett Klinder
Publikováno v:
Materials, Vol 13, Iss 5, p 1150 (2020)
Monocytes and macrophages are the first barrier of the innate immune system, which interact with abrasion and corrosion products, leading to the release of proinflammatory mediators and free reactive molecules. The aim of this study was to understand
Externí odkaz:
https://doaj.org/article/1770dd99f90c4d368f15bafb96b541f2
Autor:
Sonja Oehmcke-Hecht, Leif E. Nass, Jan B. Wichura, Stefan Mikkat, Bernd Kreikemeyer, Tomas Fiedler
Publikováno v:
Frontiers in Microbiology, Vol 8 (2017)
Streptococcus pyogenes uses lactic acid fermentation for the generation of ATP. Here, we analyzed the impact of a deletion of the L-lactate dehydrogenase gene ldh on the virulence of S. pyogenes M49. While the ldh deletion does not cause a general gr
Externí odkaz:
https://doaj.org/article/db6ec66bc80f4cd0ad2491248f516a3d
Autor:
Anika Jonitz-Heincke, Marie-Luise Sellin, Anika Seyfarth, Kirsten Peters, Brigitte Mueller-Hilke, Tomas Fiedler, Rainer Bader, Annett Klinder
Publikováno v:
Materials, Vol 12, Iss 17, p 2771 (2019)
In aseptic loosening of endoprosthetic implants, metal particles, as well as their corrosion products, have been shown to elicit a biological response. Due to different metal alloy components, the response may vary depending on the nature of the rele
Externí odkaz:
https://doaj.org/article/1133a0f7f7cf45b9b1081dbfb65bdb11
Autor:
Christin Riess, Katharina del Moral, Adina Fiebig, Philipp Kaps, Charlotte Linke, Burkhard Hinz, Anne Rupprecht, Markus Frank, Tomas Fiedler, Dirk Koczan, Sascha Troschke-Meurer, Holger N Lode, Nadja Engel, Carl Friedrich Classen, Claudia Maletzki
Publikováno v:
Neuro-Oncology. 24:i62-i63
INTRODUCTION/BACKGROUND: Glioblastoma multiforme show constitutive activation of cyclin-dependent kinases (CDKs) or arginine auxotrophy. This renders tumor cells vulnerable towards arginine-depleting substances, such as arginine deiminase from Strept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::686d1cc9bda3a10ab3f27c0a2b086190
https://doi.org/10.1093/neuonc/noac079.228
https://doi.org/10.1093/neuonc/noac079.228