Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Tomas, Björklund"'
Autor:
Facundo Peralta, Ana Abril Vidal Escobedo, Juliette López Hanotte, Martino Avallone, Tomas Björklund, Paula Cecilia Reggiani, Joaquín Pardo
Publikováno v:
Neurobiology of Disease, Vol 200, Iss , Pp 106612- (2024)
Astrocytes play key roles in the brain. When astrocyte support fails, neurological disorders follow, resulting in disrupted synaptic communication, neuronal degeneration, and cell death. We posit that astrocytes overexpressing neurotrophic factors, s
Externí odkaz:
https://doaj.org/article/d5b3c2eefcde4459a98d04ac1c2d9a61
Autor:
Jessica Giacomoni, Malin Åkerblom, Mette Habekost, Alessandro Fiorenzano, Janko Kajtez, Marcus Davidsson, Malin Parmar, Tomas Björklund
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
Direct neural conversion of endogenous non-neuronal cells, such as resident glia, into therapeutic neurons has emerged as a promising strategy for brain repair, aiming to restore lost or damaged neurons. Proof-of-concept has been obtained from animal
Externí odkaz:
https://doaj.org/article/c3d7e2d6b3b847adb1d3068e5cf75a20
Autor:
Jana Rájová, Marcus Davidsson, Martino Avallone, Morgan Hartnor, Patrick Aldrin-Kirk, Tiago Cardoso, Sara Nolbrant, Annelie Mollbrink, Petter Storm, Andreas Heuer, Malin Parmar, Tomas Björklund
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 381-394 (2023)
Cell therapy for Parkinson’s disease has experienced substantial growth in the past decades with several ongoing clinical trials. Despite increasing refinement of differentiation protocols and standardization of the transplanted neural precursors,
Externí odkaz:
https://doaj.org/article/6a1ba6995484483fa9e5ed0702cd0fd1
Autor:
Martino Avallone, Joaquín Pardo, Tadiwos F. Mergiya, Jana Rájová, Atte Räsänen, Marcus Davidsson, Malin Åkerblom, Luis Quintino, Darshan Kumar, Clive R. Bramham, Tomas Björklund
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
The activity-regulated cytoskeleton-associated (Arc) protein is essential for synaptic plasticity and memory formation. The Arc gene, which contains remnants of a structural GAG retrotransposon sequence, produces a protein that self-assembles into ca
Externí odkaz:
https://doaj.org/article/d8913b1da5ea409b971a24396f2ff4f3
Autor:
Patrick Aldrin-Kirk, Andreas Heuer, Daniella Rylander Ottosson, Marcus Davidsson, Bengt Mattsson, Tomas Björklund
Publikováno v:
Neurobiology of Disease, Vol 109, Iss , Pp 148-162 (2018)
The intricate balance between dopaminergic and cholinergic neurotransmission in the striatum has been thoroughly difficult to characterize. It was initially described as a seesaw with a competing function of dopamine versus acetylcholine. Recent tech
Externí odkaz:
https://doaj.org/article/29c9e04ff31745a89655a92d4057c4b4
Autor:
Rana Soylu-Kucharz, Natalie Adlesic, Marcus Davidsson, Tomas Björklund, Maria Björkqvist, Åsa Petersén
Huntington’s disease is a fatal neurodegenerative disorder caused by an expanded CAG triplet repeat in the huntingtin (HTT) gene. Previous research focused on neuropathology in the striatum and its association with a typical movement disorder. Dire
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f06e1d0608e8b6b8c5223f0aadb8b9a
https://doi.org/10.1101/2023.03.04.530949
https://doi.org/10.1101/2023.03.04.530949
Autor:
Patrick Aldrin-Kirk, Malin Åkerblom, Tiago Cardoso, Sara Nolbrant, Andrew F. Adler, Xiaohe Liu, Andreas Heuer, Marcus Davidsson, Malin Parmar, Tomas Björklund
Publikováno v:
Stem Cell Reports
Summary Transplantation in Parkinson's disease using human embryonic stem cell (hESC)-derived dopaminergic (DA) neurons is a promising future treatment option. However, many of the mechanisms that govern their differentiation, maturation, and integra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f354c8269265ecd1eceeb35fe619cc63
http://europepmc.org/articles/PMC8758947
http://europepmc.org/articles/PMC8758947
Publikováno v:
Current Opinion in Genetics & Development
Recent advances in cell reprogramming have made it possible to form new therapeutic cells within the body itself via a process called direct conversion or lineage reprogramming. A series of studies have shown that it is possible to reprogram resident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fee731825a0dc04547e283ba06f90433
https://doi.org/10.1016/j.gde.2021.06.002
https://doi.org/10.1016/j.gde.2021.06.002
Autor:
Marcus Davidsson, Tomas Björklund
Publikováno v:
Journal of Parkinson's Disease
Recent technological and conceptual advances have resulted in a plethora of exciting novel engineered adeno associated viral (AAV) vector variants. They all have unique characteristics and abilities. This review summarizes the development and their p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5d528d068b9fcb81181af8ff51fbc0f
https://doi.org/10.3233/jpd-212674
https://doi.org/10.3233/jpd-212674
Autor:
Christian Hansen, Tomas Björklund, Geraldine H. Petit, Martin Lundblad, Reena Prity Murmu, Patrik Brundin, Jia-Yi Li
Publikováno v:
Neurobiology of Disease, Vol 56, Iss , Pp 145-155 (2013)
Compelling evidence suggests that accumulation and aggregation of alpha-synuclein (α-syn) contribute to the pathogenesis of Parkinson's disease (PD). Here, we describe a novel Bacterial Artificial Chromosome (BAC) transgenic model, in which we have
Externí odkaz:
https://doaj.org/article/2d05b2930170445aabc1dcbeb89ee327