Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Toma A. Yakulov"'
Autor:
Toma A. Yakulov, Abhijeet P. Todkar, Krasimir Slanchev, Johannes Wiegel, Alexandra Bona, Martin Groß, Alexander Scholz, Isabell Hess, Anne Wurditsch, Florian Grahammer, Tobias B. Huber, Virginie Lecaudey, Tillmann Bork, Jochen Hochrein, Melanie Boerries, Justine Leenders, Pascal de Tullio, François Jouret, Albrecht Kramer-Zucker, Gerd Walz
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Injuries in the embryonal kidney can be repaired by a cell migratory response but how this is regulated at a molecular level is unclear. Here, the authors show in mice that deletion of Cxcl12 and Myc delays pronephros injury repair by changing mitoch
Externí odkaz:
https://doaj.org/article/1c3d2a42e5234ad3afafeb44b9152fbb
Autor:
Heon Yung Gee, Carolin E. Sadowski, Pardeep K. Aggarwal, Jonathan D. Porath, Toma A. Yakulov, Markus Schueler, Svjetlana Lovric, Shazia Ashraf, Daniela A. Braun, Jan Halbritter, Humphrey Fang, Rannar Airik, Virginia Vega-Warner, Kyeong Jee Cho, Timothy A. Chan, Luc G. T. Morris, Charles ffrench-Constant, Nicholas Allen, Helen McNeill, Rainer Büscher, Henriette Kyrieleis, Michael Wallot, Ariana Gaspert, Thomas Kistler, David V. Milford, Moin A. Saleem, Wee Teik Keng, Stephen I. Alexander, Rudolph P. Valentini, Christoph Licht, Jun C. Teh, Radovan Bogdanovic, Ania Koziell, Agnieszka Bierzynska, Neveen A. Soliman, Edgar A. Otto, Richard P. Lifton, Lawrence B. Holzman, Nicholas E. S. Sibinga, Gerd Walz, Alda Tufro, Friedhelm Hildebrandt
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Steroid-sensitive nephrotic syndrome (SRNS) can cause CKD and necessitate kidney transplant. Here the authors identify FAT1 mutations by homozygosity mapping and whole-exome sequencing in families with SRNS and provide functional mouse and zebrafish
Externí odkaz:
https://doaj.org/article/28d36207928640028a9a892d5c32fd4f
Publikováno v:
Biology Open, Vol 3, Iss 6, Pp 510-521 (2014)
Self-renewing stem cells are pools of undifferentiated cells, which are maintained in cellular niche environments by distinct tissue-specific signalling pathways. In Drosophila melanogaster, female germline stem cells (GSCs) are maintained in a somat
Externí odkaz:
https://doaj.org/article/e6fbb98824564ccd9d3483d844f5ca6c
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 9582 (2022)
Acute kidney injury (AKI) is commonly associated with severe human diseases, and often worsens the outcome in hospitalized patients. The mammalian kidney has the ability to recover spontaneously from AKI; however, little progress has been made in the
Externí odkaz:
https://doaj.org/article/2e3d0eb140074278bf3f11f3cf41a489
Autor:
Nicolas, Kayser, Friedemann, Zaiser, Anna C, Veenstra, Hui, Wang, Burulca, Göcmen, Priska, Eckert, Henriette, Franz, Anna, Köttgen, Gerd, Walz, Toma A, Yakulov
Publikováno v:
Human Molecular Genetics. 31:4143-4158
The zebrafish pronephros model, using morpholino oligonucleotides (MO) to deplete target genes, has been extensively used to characterize human ciliopathy phenotypes. Recently, discrepancies between MO and genetically defined mutants have questioned
Autor:
Alexandra Bona, Michael Seifert, Roland Thünauer, Kyra Zodel, Ian J. Frew, Winfried Römer, Gerd Walz, Toma A. Yakulov
Publikováno v:
Molecular biology of the cell. 33(13)
Defective zebrafish cmtm4 slowed the development of the posterior lateral line (pLL) by altering the Cxcr4b gradient across the pLL primordium (pLLP). Analysis in mammalian cells uncovered that CMTM4 interacted with CXCR4 and altered its glycosylatio
Autor:
Maximilian Schoels, Gerd Walz, Mingyue Zhuang, Sebastian Küchlin, Sagar, Henriette Franz, Andreas Fahrner, Annette Schmitt, Toma A. Yakulov
Publikováno v:
American Journal of Physiology-Renal Physiology
Developing organisms need to adapt to environmental variations as well as to rapid changes in substrate availability and energy demands imposed by fast-growing tissues and organs. Little is known about the adjustments that kidneys undergo in response
Autor:
Sabrina Gessler, Clara Guthmann, Vera Schuler, Miriam Lilienkamp, Gerd Walz, Toma Antonov Yakulov
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 14; Pages: 7870
Acute kidney injury (AKI) is a common complication of severe human diseases, resulting in increased morbidity and mortality as well as unfavorable long-term outcomes. Although the mammalian kidney is endowed with an amazing capacity to recover from A
Autor:
Andreas Fahrner, Miriam Lilienkamp, Gerd Walz, Priska Eckert, Hui Wang, Clara Guthmann, Toma A. Yakulov, Henriette Franz, Thanh Quang Nguyen, Maximilian Schoels, Konstantin Klingbeil
Publikováno v:
Developmental biology. 481
The corpuscles of Stannius (CS) represent a unique endocrine organ of teleostean fish that secrets stanniocalcin-1 (Stc1) to maintain calcium homeostasis. Appearing at 20–25 somite stage in the distal zebrafish pronephros, stc1-expressing cells und
Autor:
Ibrahim Avsar Ilik, Gerd Walz, Barbara Müller, Florian Heyl, Rolf Backofen, Asifa Akhtar, Toma A. Yakulov, Daniel Maticzka, Christina Engel, Luisa Estrada Mallarino, Jörn Dengjel
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
Mutations of cilia-associated molecules cause multiple developmental defects that are collectively termed ciliopathies. However, several ciliary proteins, involved in gating access to the cilium, also assume localizations at other cellular sites incl