Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Tomáš Knedlík"'
Autor:
Caterina Vianello, Federica Dal Bello, Sang Hun Shin, Sara Schiavon, Camilla Bean, Ana Paula Magalhães Rebelo, Tomáš Knedlík, Emad Norouzi Esfahani, Veronica Costiniti, Rodrigo S. Lacruz, Giuseppina Covello, Fabio Munari, Tommaso Scolaro, Antonella Viola, Elena Rampazzo, Luca Persano, Sara Zumerle, Luca Scorrano, Alessio Gianelle, Marta Giacomello
Publikováno v:
Cells, Vol 12, Iss 7, p 1089 (2023)
Recent proteomic, metabolomic, and transcriptomic studies have highlighted a connection between changes in mitochondria physiology and cellular pathophysiological mechanisms. Secondary assays to assess the function of these organelles appear fundamen
Externí odkaz:
https://doaj.org/article/62fe1550f87e4a5f8eb7dafcbe2587f7
Autor:
Klára Pospíšilová, Tomáš Knedlík, Pavel Šácha, Libor Kostka, Jiří Schimer, Jiří Brynda, Vlastimil Král, Petr Cígler, Václav Navrátil, Tomáš Etrych, Vladimír Šubr, Michael Kugler, Milan Fábry, Pavlína Řezáčová, Jan Konvalinka
Publikováno v:
ACS Omega, Vol 4, Iss 4, Pp 6746-6756 (2019)
Externí odkaz:
https://doaj.org/article/f19d4dce08f848dba46628cafbb8c70d
Autor:
Tomáš Knedlík, Barbora Vorlová, Václav Navrátil, Jan Tykvart, František Sedlák, Šimon Vaculín, Miloslav Franěk, Pavel Šácha, Jan Konvalinka
Publikováno v:
FEBS Open Bio, Vol 7, Iss 9, Pp 1362-1378 (2017)
Glutamate carboxypeptidase II (GCPII), also known as prostate‐specific membrane antigen (PSMA) or folate hydrolase, is a metallopeptidase expressed predominantly in the human brain and prostate. GCPII expression is considerably increased in prostat
Externí odkaz:
https://doaj.org/article/289a58f040874623959efd5bfbca5e3c
Autor:
Pavel Šácha, Jan Konvalinka, Jan Tykvart, Václav Navrátil, Frantisek Sedlak, Miloslav Franěk, Tomáš Knedlík, Barbora Vorlová, Simon Vaculin
Publikováno v:
FEBS Open Bio
Glutamate carboxypeptidase II (GCPII), also known as prostate‐specific membrane antigen (PSMA) or folate hydrolase, is a metallopeptidase expressed predominantly in the human brain and prostate. GCPII expression is considerably increased in prostat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f2d1c3560a45abf1fa093ecd07e24b5
https://doi.org/10.1002/2211-5463.12276
https://doi.org/10.1002/2211-5463.12276
Autor:
Tomáš Knedlík, Vladimir Subr, Pavel Šácha, Anna Březinová, Libor Kostka, Kristýna Blažková, Petra Dvořáková, Jan Konvalinka, Petr Šimon
Publikováno v:
ACS chemical biology. 13(12)
Identifying protein targets of bioactive small molecules often requires complex, lengthy development of affinity probes. We present a method for stochastic modification of small molecules of interest with a photoactivatable phenyldiazirine linker. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c1aa4bd31c7b3d7c7bb3fdf506ba2bb
https://pubmed.ncbi.nlm.nih.gov/30489064
https://pubmed.ncbi.nlm.nih.gov/30489064
Autor:
Vladimir Subr, Tomáš Knedlík, Pavel Šácha, Karel Ulbrich, Václav Navrátil, Frantisek Sedlak, Jan Tykvart, Jiří Schimer, Jan Konvalinka, Jiří Strohalm, Pavel Majer, Petra Dvořáková, Jan Parolek
Publikováno v:
Angewandte Chemie (International Ed. in English)
Antibodies are indispensable tools for biomedicine and anticancer therapy. Nevertheless, their use is compromised by high production costs, limited stability, and difficulty of chemical modification. The design and preparation of synthetic polymer co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::078ba7fa74f7f313eab7f5615f94b964
https://doi.org/10.1002/anie.201508642
https://doi.org/10.1002/anie.201508642
Autor:
Jan Konvalinka, Petra Dvořáková, Petr Busek, Tomáš Knedlík, Libor Kostka, Aleksi Sedo, Tomáš Etrych, Pavel Šácha, Vladimir Subr, Lucie Sromova, Jiří Schimer
Publikováno v:
Journal of medicinal chemistry. 60(20)
Proteases are directly involved in cancer pathogenesis. Expression of fibroblast activation protein (FAP) is upregulated in stromal fibroblasts in more than 90% of epithelial cancers and is associated with tumor progression. FAP expression is minimal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7285ab55d6e3701551ade6a27580345b
https://pubmed.ncbi.nlm.nih.gov/28953383
https://pubmed.ncbi.nlm.nih.gov/28953383
Autor:
Jan Konvalinka, Petr Šimon, Libor Kostka, Petra Dvořáková, Pavel Šácha, Vladimir Subr, Tomáš Knedlík, Anna Březinová, Kristyna Blazkova
Publikováno v:
Cancer Immunology Research. 7:B147-B147
The renaissance of phenotypic screening leads to the discovery of biologically active small molecules resulting in a high need to quickly and efficiently identify their protein target. This is most commonly done by a preparation of an affinity probe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::354be8d8f7e498a42f73248deaec8535
https://doi.org/10.1158/2326-6074.cricimteatiaacr18-b147
https://doi.org/10.1158/2326-6074.cricimteatiaacr18-b147
Autor:
Tomáš Knedlík, Jan Tykvart, Jana Starková, Pavel Šácha, Jan Konvalinka, Cyril Bařinka, Jacek Lubkowski
Publikováno v:
Protein Expression and Purification. 82:106-115
Affinity purification is a useful approach for purification of recombinant proteins. Eukaryotic expression systems have become more frequently used at the expense of prokaryotic systems since they afford recombinant eukaryotic proteins with post-tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da943a8685c86b3286aef961341998c6
https://doi.org/10.1016/j.pep.2011.11.016
https://doi.org/10.1016/j.pep.2011.11.016
Publikováno v:
The Prostate. 74(7)
Glutamate carboxypeptidase II (GCPII) is a transmembrane enzyme that cleaves N-acetyl-L-aspartyl-L-glutamate (NAAG) in the brain. GCPII is highly expressed in the prostate and prostate cancer and might be associated with prostate cancer progression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::84aea6b63f193216cef56b92b5c2589d
https://pubmed.ncbi.nlm.nih.gov/24647901
https://pubmed.ncbi.nlm.nih.gov/24647901