The proteomic profile is altered but not repaired after bariatric surgery in type 2 diabetes pigs

Autor: Karolina Ferenc, Michał Marcinkowski, Jarosław Olszewski, Paweł Kowalczyk, Tomaš Pilžys, Damian Garbicz, Naser Dib, Bianka Świderska, Piotr Matyba, Zdzisław Gajewski, Elżbieta Grzesiuk, Romuald Zabielski

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)

Abstract To reveal the sources of obesity and type 2 diabetes (T2D) in humans, animal models, mainly rodents, have been used. Here, we propose a pig model of T2D. Weaned piglets were fed high fat/high sugar diet suppling 150% of metabolizable energy.

Externí odkaz: https://doaj.org/article/a1890a23242344b092811861fc4bb6a7

Effect of Posttranslational Modifications on the Structure and Activity of FTO Demethylase

Autor: Maciej Kozak, Tomaš Pilžys, Damian Mielecki, Jarosław Poznański, Grzegorz Nowaczyk, Maria Winiewska-Szajewska, Kaja Przygońska, Maciej Gielnik, Michał Marcinkowski, Agnieszka M. Maciejewska, Ewa Szolajska, Elżbieta Grzesiuk, Michał Taube, Karolina Ferenc, Janusz Debski, Damian Garbicz, Jan Piwowarski

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 4512, p 4512 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 9

The FTO protein is involved in a wide range of physiological processes, including adipogenesis and osteogenesis. This two-domain protein belongs to the AlkB family of 2-oxoglutarate (2-OG)- and Fe(II)-dependent dioxygenases, displaying N6-methyladeno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7308e6118a7ebd0347589fa8322609f2
https://www.mdpi.com/1422-0067/22/9/4512

Intracellular and tissue specific expression of FTO protein in pig: changes with age, energy intake and metabolic status

Autor: Damian Garbicz, Romuald Zabielski, Karolina Ferenc, Małgorzata Dylewska, Zdzislaw Gajewski, Oleksandr Skorobogatov, Tomaš Pilžys, Elżbieta Grzesiuk, Michał Marcinkowski

Publikováno v: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)

Genome-wide association studies in the FTO gene have identified SNPs correlating with obesity and type 2 diabetes. In mice, lack of Fto function leads to intrauterine growth retardation and lean phenotype, whereas in human it is lethal. The aim of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c4ab3758333f9f1c1489304037759f4
https://pubmed.ncbi.nlm.nih.gov/32747736

Calmodulin as Ca2+-Dependent Interactor of FTO Dioxygenase

Autor: Jarosław Poznański, Damian Garbicz, Elżbieta Grzesiuk, Karolina Ferenc, Oleksandr Skorobogatov, Jan Piwowarski, Maria Winiewska-Szajewska, Michał Marcinkowski, Kaja Przygońska, Tomaš Pilžys

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 10869, p 10869 (2021)
Volume 22
Issue 19

FTO is an N6-methyladenosine demethylase removing methyl groups from nucleic acids. Several studies indicate the creation of FTO complexes with other proteins. Here, we looked for regulatory proteins recognizing parts of the FTO dioxygenase region. I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::698b08e5b38eb5ad29937d0bc3d84aa5
https://doi.org/10.3390/ijms221910869

Anticancer agents found in environment affect Daphnia at population, individual and molecular levels

Autor: Michał Marcinkowski, Małgorzata Grzesiuk, Damian Mielecki, Damian Garbicz, Bianka Świderska, Tomaš Pilžys, Agata Malinowska, Elżbieta Grzesiuk, Anna Bednarska

Publikováno v: Aquatic toxicology (Amsterdam, Netherlands). 215

Pharmaceuticals are used in medical treatment on a large scale and as a waste contaminate freshwater ecosystems. Growing amount of so-called civilization diseases, such as different type of cancer, significantly contribute to this form of pollution.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac5c77e5006617dd5b55801d420098a6
https://pubmed.ncbi.nlm.nih.gov/31526926